Research group  leaders at the BBZ:  Dr. Ronny Schulz  

Research group
leaders at the BBZ:
Dr. Ronny Schulz

Summary

Publications
Patents

Publications

Lehmann J, Schulz RM, Sanzenbacher R.
Strategische Betrachtungen zur Konzeption und Wahl von Tiermodellen bei nicht-klinischen Prüfungen von zellbasierten Therapeutika. Special Issue: Cell-based Medicinal Products (CBMP). Bundesgesundheitsblatt [2015], invited.

Henkelmann R, Marquaß B, Sanzenbacher R, Schulz RM.
Cochrane Review on stem cell therapy of cartilage defects of the knee. Cochrane Musculoskeletal Group [2015], invited.

Schöne M, Männicke N, Somerson JS, Marquaß B, Henkelmann R, Aigner T, Raum K, Schulz RM.
3D ultrasound biomicroscopy for assessment of cartilage repair tissue: Volumetric characterization and correlation to established classification systems. The American Journal of Sports Medicine [2015], submitted.

Sauber J, Meyer S, Schmidt C, Schulz RM, Langer S.
Technical Report: Dorsal skinfold chamber models in mice. European Surgical Research [2015], submitted.

Faltus T, Schulz RM.
Die arzneimittelrechtliche Handhabung zellbasierter Therapien in Point-of-Care-Behandlungsmodellen. Pharmarecht [2015], 5:228-239, in press.

Zscharnack M, Krause C, Aust G, Thümmler C, Peinemann F, Keller T, Smink JJ, Holland H, Somerson JS, Knauer J, Schulz RM, Lehmann J.
Preclinical Good Laboratory Practice-Compliant Safety Study to Evaluate Biodistribution and Tumorigenicity of a Cartilage Advanced Therapy Medicinal Product (ATMP). Journal of Translational Medicine [2015], in press.

Schulz RM, Haberhauer M, Zernia G, Pösel C, Thümmler C, Somerson JS, Huster D.
Comprehensive characterization of chondrocyte cultures in plasma and whole blood biomatrices for cartilage tissue engineering. Journal of tissue engineering and regenerative medicine [2014], 8(7):566-77.
PubMed 
Abstract

Hoffmann M, Kuska J, Zscharnack M, Loeffler M, Galle J.
Spatial organization of mesenchymal stem cells in vitro--results from a new individual cell-based model with podia. PLoS One [2011], 6(7):e21960.

PubMed 
Abstract


Marquass B, Schulz R, Hepp P, Zscharnack M, Aigner T, Schmidt S, Stein F, Richter R, Osterhoff G, Aust G, Josten C, Bader A.
Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year. The American Journal of Sports Medicine [2011], 39(7):1401–1412.

PubMed 
Abstract

Schmitt A, Imhoff AB, Vogt S, Zscharnack M, Schulz R, Marquass B. Predifferentiated mesenchymal stem cells for osteochondral defects: Letter. The American Journal of Sports Medicine [2011], 39(6):NP12–NP15.
PubMed 
Abstract

Chowdhury TT, Schulz RM, Rai SS, Thuemmler CB, Wuestneck N, Bader A, Homandberg GA.
Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs. Arthritis Res Ther (Arthritis research & therapy) [2010], 12(3):R82.
PubMed 
Abstract


Galle J, Bader A, Hepp P, Grill W, Fuchs B, Käs JA, Krinner A, Marquass B, Müller K, Schiller J, Schulz RM, Buttlar M von, Burg E von der, Zscharnack M, Löffler M.
Mesenchymal stem cells in cartilage repair: state of the art and methods to monitor cell growth, differentiation and cartilage regeneration. Curr Med Chem (Current medicinal chemistry) [2010], 17(21):2274–2291.

PubMed 
Abstract

Marquass B, Somerson JS, Hepp P, Aigner T, Schwan S, Bader A, Josten C, Zscharnack M, Schulz RM.
A novel MSC-seeded triphasic construct for the repair of osteochondral defects. J Orthop Res (Journal of orthopaedic research) [2010], 28(12):1586–1599.

PubMed 
Abstract

Scheidt HA, Schibur S, Magalhães A, Azevedo ER de, Bonagamba TJ, Pascui O, Schulz R, Reichert D, Huster D.
The mobility of chondroitin sulfate in articular and artificial cartilage characterized by 13C magic-angle spinning NMR spectroscopy. Biopolymers [2010], 93(6):520–532.

PubMed 
Abstract


Zscharnack M, Hepp P, Richter R, Aigner T, Schulz R, Somerson J, Josten C, Bader A, Marquass B.
Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model. The American Journal of Sports Medicine [2010], 38(9):1857–1869.

PubMed 
Abstract

Hepp P, Osterhoff G, Niederhagen M, Marquass B, Aigner T, Bader A, Josten C, Schulz R.
Perilesional changes of focal osteochondral defects in an ovine model and their relevance to human osteochondral injuries. The Journal of bone and joint surgery. British volume [2009], 91(8):1110–1119.

PubMed 
Abstract

Kock LM, Schulz RM, van Donkelaar CC, Thümmler CB, Bader A, Ito K. RGD-dependent integrins are mechanotransducers in dynamically compressed tissue-engineered cartilage constructs. Journal of biomechanics [2009], 42(13):2177–2182.
PubMed 
Abstract


Krinner A, Zscharnack M, Bader A, Drasdo D, Galle J.
Impact of oxygen environment on mesenchymal stem cell expansion and chondrogenic differentiation. Cell Prolif (Cell proliferation) [2009], 42(4):471–484.
PubMed 
Abstract

Zscharnack M, Poesel C, Galle J, Bader A.
Low oxygen expansion improves subsequent chondrogenesis of ovine bone-marrow-derived mesenchymal stem cells in collagen type I hydrogel. Cells Tissues Organs [2009], 190(2):81–93.
PubMed 
Abstract

Fuchs B, Schiller J, Süss R, Zscharnack M, Bader A, Müller P, Schürenberg M, Becker M, Suckau D.
Analysis of stem cell lipids by offline HPTLC-MALDI-TOF MS. Analytical and bioanalytical chemistry [2008], 392(5):849–860.
PubMed 
Abstract

Haberhauer M, Zernia G, Deiwick A, Pösel C, Bader A, Huster D, Schulz RM.
Cartilage tissue engineering in plasma and whole blood scaffolds. Adv Mater (Advanced Materials) [2008], 20(11):2061–2067.

Abstract

Schulz RM, Wustneck N, van Donkelaar CC, Shelton JC, Bader A. Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs. Biotechnol Bioeng (Biotechnology and Bioengineering) [2008], 101(4):714–728.
PubMed 
Abstract

Schulz RM, Zscharnack M, Hanisch I, Geiling M, Hepp P, Bader A.
Cartilage tissue engineering by collagen matrix associated bone marrow derived mesenchymal stem cells. Bio-medical materials and engineering [2008], 18(1 Suppl):S55-70.
PubMed 
Abstract

van Donkelaar CC, Schulz R.
Review on patents for mechanical stimulation of articular cartilage tissue engineering. Recent Patents on Biomedical Engineering [2008], 1(1):1–12.

Abstract

Schulz RM, Bader A.
Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes. Eur Biophys J (European biophysics journal) [2007], 36(4-5):539–568.
PubMed 
Abstract

Schulz R, Höhle S, Zernia G, Zscharnack M, Schiller J, Bader A, Arnold K, Huster D.
Analysis of extracellular matrix production in artificial cartilage constructs by histology, immunocytochemistry, mass spectrometry, and NMR spectroscopy. Journal of nanoscience and nanotechnology [2006], 6(8):2368–2381.
PubMed 
Abstract

Seleverstov O, Zabirnyk O, Zscharnack M, Bulavina L, Nowicki M, Heinrich J, Yezhelyev M, Emmrich F, O'Regan R, Bader A.
Quantum dots for human mesenchymal stem cells labeling. A size-dependent autophagy activation. Nano Lett (Nano letters) [2006], 6(12):2826–2832.
PubMed 
Abstract

Hepp P, Bader A, Josten C, Rose T, Schulz R.
Tissue engineering von Knorpelzellen. Arthroskopie [2005], 18(3):233–238.

Abstract

Patents

Schulz RM and Bader A.
Method and bioreactor for the cultivation and stimulation of three-dimensional, vital and mechanically resistant cell transplants. US020070026517A1, WO002005040332A2, CA000002543374A1. 06.05.2005.


last update: 16.10.2017 

Contact

Dr. Ronny M. Schulz
Dipl. Ing. (FH), cand. MSc
Universität Leipzig
Centre for Biotechnology and Biomedicine
Deutscher Platz 5
04103 Leipzig

Phone: +49 341 97-31352
Fax: +49 341 97-31359
E-Mail

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