Forschungsbericht 1996

Veröffentlichungen 1995

Institut für Medizinische Informatik, Statistik und Epidemiologie

Wissenschaftliche Veröffentlichungen

• Therapeutische und epidemiologische Studien

• Hasenclever, D.; Sextro, M.

  Safety of AlloPBPCT donors: Biometrical considerations on monitoring long term risks Bone Marrow Transplantation 17, Suppl. 2, (1996) 28-30

• Hasenclever, D.; Löffler, M.; Diehl, V. for the German Hodgkin's Lymphoma

  Study Group: Rationale for dose escalation of first line conventional chemotherapy in advanced Hodgkin's disease Annals of Oncology 7, Suppl. 4, (1996) S95-S98

• Duehmke, E.; Diehl, V.; Löffler, M.; Müller, R.-P.; Rühl, U.; Willich, N.; Georgii,

  A.; Roth, S.; Matthaei, D.; Sehlen, S.; Brosteanu, O.; Hasenclever, D.; Wilkowski, R.; Becker, K. Randomized trial with early-stage hodgkin's disease testing 30 Gy vs. 40 Gy extended field radiotherapy alone International Journal of Radiation Oncology, Biology and Physics 36 (1996) 305-310

• Teuber, S.; Klöss, M.; Lautenschläger, C.

  Czynniki anamnestyczne, kliniczne i prognostyczne w raku wargi. (Anamnestische, klinische und prognostische Faktoren beim Lippenkarzinom) Magazyn Stomatologiczny 12 (1996) 44-47

• Asselain, B.; Fourquet, A.; Hoang, T.; Tsodikov, A.D.; Yakovlev, A.Yu.

  A parametric regression model of tumor recurrence: An application to the analysis of clinical data on breast cancer Statistics and Probability Letters 29 (1996) 271-278

• Ivankov, A.; Tsodikov, A.D.; Yakovlev, A.Yu.

  Estimation of the proliferative potential of the recurrent tumor: Verification of parametric methods by simulation Problems in Oncology (in Russian) 42 (1996) 34-39

• Yakovlev, A.Yu.; Hanin, L.G.; Rachev, S.T.; Tsodikov, A.D.

  A distribution of tumor size at detection and its limiting form Proceedings of the National Academy of Sciences (USA) 93 (1996) 6671-6675

• Ivankov, A.; Tsodikov, A.D.; Yakovlev, A.Yu.

  Computer simulation of tumor recurrence Journal of Biological Systems 4 (1996) 291-302

• Brosteanu, O.; Löffler, M.; Hasenclever, D.; Sextro, M.; Cosset, J.; Dahlberg,

  S.; Fisher, R.; Gray, R.; Henry-Amar, M.; Hoppe, R.; Somers, R.; Specht, L. for the IDHD-Overview study group: Randomized trials comparing combined modality treatment and chemotherapy alone in Hodgkin's Disease (HD): A metaanalysis Annual Congress of the German and the Austrian Society of Hematology, Düsseldorf, 3.-7.10.1996, Annals of Hematology 73, Suppl. II, (1996) #716

• Trümper, L.; Renner, Ch.; Klöss, M.; Hasenclever, D.; Schnabel, K.; Feller, A.C.;

  Löffler, M.; Pfreundschuh, M. Therapy of high-grade Non-Hodgkin's Lymphomas with CHOEP (CHOP+ETOPOSIDE) in 14-day intervals. A Phase III multicenter trial of the German NHL-Consensus Trial Group VI. International Conference on Malignant Lymphoma, Lugano June 5-8, Annals of Oncology 7, (1996) 58, #201

• Schmitz, N.; Hasenclever, D.; Goldstone, A.H.; Diehl, V. on behalf of the

  European Group for Blood and Marrow Transplantation (EBMT) and the German Hodgkin's Disease Study Group (GHSG): Early high-dose therapy (EHDT) in first complete remission (CR) for patients (PTS) with high-risk Hodgkin's disease (HD)? 8th International Symposium on Autologous Marrow and Blood Transplantation (Abstrakt), 1996

• Hasenclever, D. and Diehl, V. for the International Prognostic Factors Project on

  Advanced Hodgkin's Disease: A prognostic index for Advanced Hodgkin's Disease: Results of the international Prognostic Factors Project Annual Congress of the German and the Austrian Society of Hematology, Düsseldorf, 3.-7.10.1996, Annals of Hematology 73, Suppl. II, (1996) #598

• Hasenclever, D. and Diehl, V. for the International Prognostic Factors Project on

  Advanced Hodgkin's Disease: A prognostic index to predicttumor control in Advanced Hodgkin's Disease 38th Annual Meeting of the American Society of Hematology, Orlando (Florida), December 6-10, Blood 88, Suppl. 1, (1996) 673a, #2680

• Tesch, H.; Lathan, B.; Hasenclever, D.; Rüffer, U.; Sieber, M.; Engert, A.;

  Pfreundschuh, M.; Koch, P.; Adler, M.; Müller, U.; Schalk, P.; Dölken, G.; Worst, P.; Boissevain, F.; Löffler, M.; Diehl, V. The role of dose intensity for advanced stage Hodgkin's Disease - Studies of the German Hodgkin Study Group (GSGH) Annual Congress of the German and the Austrian Society of Hematology, Düsseldorf, 3.-7.10.1996, Annals of Hematology 73, Suppl. II, (1996) #714

• Tesch, H.; Lathan, B.; Rüffer, U.; Sieber, M.; Engert, A.; Hasenclever, D.;

  Pfreundschuh, M.; Franklin, J.; Koch, P.; Adler, M.; Müller, U.; Schalk, P.; Dölken, G.; Worst, P.; Boissevain, F.; Diehl, V. Escalation of dose intensity for advanced stage Hodgkin's Disease using the BEACOPP scheme - Studies of the German Hodgkin Study Group (GSGH) 38th Annual Meeting of the American Society of Hematology, Orlando (Florida), December 6-10, 1996, Blood 88, Suppl. 1, (1996) 673a, #2682 Tesch, H.; Paulus, U.; Hasenclever, D.; Lieberz, D.; Sextro, M.; Sieber, M.; Rüffer, U.; Engert, A.; Koch, T.; Duehmke, E.; Georgii, A.; Löffler, M.; Pfreundschuh, M. and Diehl, V. for the German Hodgkin's Lymphoma Study Group (GHSG): Stage IVb and anemia are poor prognostic factors in advanced stages of Hodgkin's Disease - Results of the HD6 study of the GSGH Annual Congress of the German and the Austrian Society of Hematology; Düsseldorf, 3.-7.10.1996, Annals of Hematology 73, Suppl. II, (1996) #715

• Loeffler, M.; Brosteanu, O.; Hasenclever, D.; Sextro, M.; Cosset, J.; Dahlberg,

  S.; Fisher, R.; Gray, R.; Henry-Amar, M.; Hoppe, R.; Somers, R.; Specht, L. for the IDHD-Overview study group: Combined modality treatment vs. chemotherapy alone in Hodkin's disease (HD): an overview on randomized trials 38th Annual Meeting of the American Society of Hematology, Orlando (Florida), December 6-10, 1996, Blood 88, Suppl. 1, (1996) 91a, #353

• Tesch, H.; Paulus, U.; Hasenclever, D.; Lieberz, D.; Sextro, M.; Sieber, M.;

  Rüffer, U.; Engert, A.; Koch, T.; Duehmke, E.; Georgii, A.; Löffler, M.; Pfreundschuh, M. and Diehl, V. for the German Hodgkin's Lymphoma Study Group (GHSG): The rapidly alternating scheme COPP-ABV-IMEP is equally effective as COPP- ABVD in advanced stages of Hodgkin's disease - Results of the HD6 study of the GSGH 38th Annual Meeting of the American Society of Hematology, Orlando (Florida), December 6-10, 1996, Blood 88, Suppl. 1, (1996) 92a, #357

• Tesch, H.; Paulus, U.; Hasenclever, D.; Lieberz, D.; Sextro, M.; Sieber, M.;

  Rüffer, U.; Engert, A.; Koch, T.; Duehmke, E.; Georgii, A.; Löffler, M.; Pfreundschuh, M. and Diehl, V. for the German Hodgkin's Lymphoma Study Group (GHSG): Stage IVb and anemia are poor prognostic factors in advanced stages of Hodgkin's Disease - Results of the HD6 study of the GSGH 38th Annual Meeting of the American Society of Hematology, Orlando (Florida), December 6-10, 1996, Blood 88, Suppl. 2, (1996) 195b, #3506

• Löffler, M.; Bratke, T.; Paulus, U.; Potten, C.S.

  State dependent stochastic models of stem cell organisation in the intestinal epithelium 3rd European Conference on Mathematics applied to Biology and Medicine (ECMBM 96), Heidelberg, October 6-10, Abstracts, (1996) 104

• Löffler, M.

  Was gewinnt der Lymphompatient an Lebenszeit durch die moderne Therapie ? Eine kritische Studie. Tagung Maligne Lymphome"Essen, 4. Mai 1996 Tumordiagnostic und Therapie 17 (1996) 139-140

• Trümper, L.; Renner, Ch.; Klöss, M.; Hasenclever, D.; Schnabel, K.; Feller, A.C.;

  Löffler, M.; Pfreundschuh, M. Therapy of high-grade Non-Hodgkin's Lymphomas with CHOEP (CHOP+ETOPOSIDE) in 14-day intervals. A Phase III multicenter trial of the German NHL-Consensus Trial Group VI. International Conference on Malignant Lymphoma, Lugano June 5-8, Annals of Oncology 7, (1996) 58, #201

• Schmitz, N.; Hasenclever, D.; Goldstone, A.H.; Diehl, V. on behalf of the

  European Group for Blood and Marrow Transplantation (EBMT) and the German Hodgkin's Disease Study Group (GHSG): Early high-dose therapy (EHDT) in first complete remission (CR) for patients (PTS) with high-risk Hodgkin's disease (HD)? 8th International Symposium on Autologous Marrow and Blood Transplantation (Abstrakt), 1996

• Hasenclever, D. and Diehl, V. for the International Prognostic Factors Project on

  Advanced Hodgkin's Disease: A prognostic index for Advanced Hodgkin's Disease: Results of the international Prognostic Factors Project Annual Congress of the German and the Austrian Society of Hematology, Düsseldorf, 3.-7.10.1996, Annals of Hematology 73, Suppl. II, (1996) #598

• Hasenclever, D. and Diehl, V. for the International Prognostic Factors Project on

  Advanced Hodgkin's Disease: A prognostic index to predicttumor control in Advanced Hodgkin's Disease 38th Annual Meeting of the American Society of Hematology, Orlando (Florida), December 6-10, Blood 88, Suppl. 1, (1996) 673a, #2680

• Tesch, H.; Lathan, B.; Hasenclever, D.; Rüffer, U.; Sieber, M.; Engert, A.;

  Pfreundschuh, M.; Koch, P.; Adler, M.; Müller, U.; Schalk, P.; Dölken, G.; Worst, P.; Boissevain, F.; Löffler, M.; Diehl, V. The role of dose intensity for advanced stage Hodgkin's Disease - Studies of the German Hodgkin Study Group (GSGH) Annual Congress of the German and the Austrian Society of Hematology, Düsseldorf, 3.-7.10.1996, Annals of Hematology 73, Suppl. II, (1996) #714

• Tesch, H.; Lathan, B.; Rüffer, U.; Sieber, M.; Engert, A.; Hasenclever, D.;

  Pfreundschuh, M.; Franklin, J.; Koch, P.; Adler, M.; Müller, U.; Schalk, P.; Dölken, G.; Worst, P.; Boissevain, F.; Diehl, V. Escalation of dose intensity for advanced stage Hodgkin's Disease using the BEACOPP scheme - Studies of the German Hodgkin Study Group (GSGH) 38th Annual Meeting of the American Society of Hematology, Orlando (Florida), December 6-10, 1996, Blood 88, Suppl. 1, (1996) 673a, #2682 Tesch, H.; Paulus, U.; Hasenclever, D.; Lieberz, D.; Sextro, M.; Sieber, M.; Rüffer, U.; Engert, A.; Koch, T.; Duehmke, E.; Georgii, A.; Löffler, M.; Pfreundschuh, M. and Diehl, V. for the German Hodgkin's Lymphoma Study Group (GHSG): Stage IVb and anemia are poor prognostic factors in advanced stages of Hodgkin's Disease - Results of the HD6 study of the GSGH Annual Congress of the German and the Austrian Society of Hematology; Düsseldorf, 3.-7.10.1996, Annals of Hematology 73, Suppl. II, (1996) #715

• Loeffler, M.; Brosteanu, O.; Hasenclever, D.; Sextro, M.; Cosset, J.; Dahlberg,

  S.; Fisher, R.; Gray, R.; Henry-Amar, M.; Hoppe, R.; Somers, R.; Specht, L. for the IDHD-Overview study group: Combined modality treatment vs. chemotherapy alone in Hodkin's disease (HD): an overview on randomized trials 38th Annual Meeting of the American Society of Hematology, Orlando (Florida), December 6-10, 1996, Blood 88, Suppl. 1, (1996) 91a, #353

• Tesch, H.; Paulus, U.; Hasenclever, D.; Lieberz, D.; Sextro, M.; Sieber, M.;

  Rüffer, U.; Engert, A.; Koch, T.; Duehmke, E.; Georgii, A.; Löffler, M.; Pfreundschuh, M. and Diehl, V. for the German Hodgkin's Lymphoma Study Group (GHSG): The rapidly alternating scheme COPP-ABV-IMEP is equally effective as COPP- ABVD in advanced stages of Hodgkin's disease - Results of the HD6 study of the GSGH 38th Annual Meeting of the American Society of Hematology, Orlando (Florida), December 6-10, 1996, Blood 88, Suppl. 1, (1996) 92a, #357

• Tesch, H.; Paulus, U.; Hasenclever, D.; Lieberz, D.; Sextro, M.; Sieber, M.;

  Rüffer, U.; Engert, A.; Koch, T.; Duehmke, E.; Georgii, A.; Löffler, M.; Pfreundschuh, M. and Diehl, V. for the German Hodgkin's Lymphoma Study Group (GHSG): Stage IVb and anemia are poor prognostic factors in advanced stages of Hodgkin's Disease - Results of the HD6 study of the GSGH 38th Annual Meeting of the American Society of Hematology, Orlando (Florida), December 6-10, 1996, Blood 88, Suppl. 2, (1996) 195b, #3506

• Schmitz, S.; Franke, H.; Wichmann, H.E.; Diehl, V.

  The effect of continuous G-CSF application in human cyclic neutropenia: a model analysis British Journal of Hematology 90/1, (1995) S. 41-47

• Lohri, A.; Leyvraz, S.; Cerny, T.; Hess, U.; Honegger, H.P.; Greiner, R.;

  Castiglione, M.; Herrmann, R.; Löffler, M.; Hasenclever, D.; Diehl, V. Participation in multicenter studies as quality control in the therapy of Hodgkin disease: an interim report Schweizer Medizinische Wochenschrift 125 (1995) 6, 217-224

• Diehl, V.; Sieber, M.; Rüffer, U.; Lathan, B.; Hasenclever, D.; Pfreundschuh, M.;

  Loeffler, M.; Lieberz, D.; Koch, P.; Adler, M.; Tesch, H. for the German Hodgkin's Lymphoma Study Group (GHSG): BEACOPP: An intensified chemotherapy regimen in advanced Hodgkin's disease Annals of Oncology 8, (1997) 1-6

• Löffler, M.; Bratke, T.; Paulus, U.; Potten, C.S.

  State dependent stochastic models of stem cell organisation in the intestinal epithelium 3rd European Conference on Mathematics applied to Biology and Medicine (ECMBM 96), Heidelberg, October 6-10, Abstracts, (1996) 104

• Schuster, E.; Bär, I.; Kaltenhäuser, S.; Häntzschel, H.; Löffler, M.

  Longitudinal data analysis of a study of early rheumatoid arthritis. In: Prat A. und Ripoll E.: Compstat-Proceedings in Computational Statistics, Espana (1996)

• Tsodikov, A.; Löffler, M.

  Modelling secondary leukemia via a biologically based regression model with time dependent covariates, 3rd ECMBM, Heidelberg, (1996)

• Yakovlev, A.Yu.; Tsodikov, A.D.

  Stochastic Models of Tumor Latency and their Biostatistical Applications World Scientific Publisher, 1996

• Medizinische Informatik und Klinikuminformationssystem

• Winter, A.

  Integration von Anwendungssystemen in heterogene Krankenhausinformationssysteme - Vorgehensweise und Erfahrungen Management und Krankenhaus 6 (1996) 33-34

• Haux, R.; Grothe, W.; Runkel, M.; Schackert, H.K.; Windeler, H.-J.; Winter, A.;

  Wirtz, R.; Herfarth, C.; Kunze S. Knowledge retrieval as one type of knowledge-based decision support in medicine: results of an evaluation study International Journal of Bio-Medical Computing 41 (1996) 69-85

• Haux, R.; Schmücker, P.; Winter, A.

  Gesamtkonzept der Informationsverarbeitung im Krankenhaus. In: Praxis der Informationsverarbeitung im Krankenhaus Landsberg: ecomed, (1996) S. 25-37

• Winter, A.; Haux, R.; Schmücker, P.

  Integration von Anwendungssystemen in heterogene Krankenhausinformationssysteme - Vorgehensweise und Erfahrungen. In: Praxis der Informationsverarbeitung im Krankenhaus Landsberg: ecomed, (1996) S. 59-66

• Winter, A.; Lagemann, A.; Budig, B.; Grothe, W.; Haux, R.; Herr, S.; Pilz, J.;

  Sawinski, R.; Schmücker, P. Integration of Health Professional Workstations in Hospital Information Systems. In: Brender, J.; Christensen, J.P.; Scherrer, J.-R.; McNair, P. (eds.): Medical Informatics Europe 96 Amsterdam: IOS Press, (1996) S. 685-689

• Frank, J.; Rupprecht, B.; Schmelmer, V.

  Knowledge-based assistance for the development of drugs IEEE Expert - Intelligent systems & their applications 12, (1997) 40-48 Bioinformatische und biomathematische Modelle

• Calenbuhr, V.; Bersini, H.; Varela, F.J.

  Natural tolerance as a function of network connectivity International Journal of Bifurcation and Chaos 6, (1996)

• Calenbuhr, V.; Bersini, H.; Varela, F.J.

  Immune resonse toward auto-Ag and growing-Ag as a function of network connectivity, German (GCB 96), Leipzig, 30. September - 2. Oktober 1996 (Poster), Computer Science and Biology - Proceedings of the German Conference on Bioinformatics, (1996) 179-180

• de Haan, G.; Dontje, B.; Engel, C.; Löffler, M.; Nijhof, W.

  Prophylactic pretreatment with hematopoietic growth factors induces expansions of primitive cell compartements and results in protection against 5- fluorouracil-induced toxicity Blood 87/11 (1996) 4581-4588

• Löffler, M.; Meineke, F.; Bratke, T.

  Modelle räumlicher und zeitlicher Organisation von Epithelien. 41. Jahrestagung der GMDS, Bonn, 15.-19. September, Abstracts, (1996) 196

• Meineke, F.

  An elementary model for cell proliferation, differentiation and the motion in the intestinal crypt of mammals. 41. Jahrestagung der GMDS, Bonn, 15.-19. September, Abstracts, (1996) 197

• Meineke, F.; Löffler, M.

  A dynamic model of spatial cell arrangement in proliferative epithelia using locally controlled tesselat. German Conference on Bioinformatics (GCB 96), Leipzig, 30. September - 2. Oktober 1996, Computer Science and Biology - Proceedings of the German Conference on Bioinformatics,(1996) 272-274

• Wissensbasierte Systeme in der Medizin

• Hofestädt, R.; Löffler, M.; Lengauer, T.

  Informatik in den Biowissenschaften it+ti - Informationstechnik und Technische Informatik 38 (1996) 5-7 it+ti - Informationstechnik und Technische Informatik 38 (1996) 5-7