Research concept
IZBI offers our partners a novel way of research management to
serve their demands in the most efficient way.
IZBI is designed to support cooperating scientists on a project
basis. Projects can be either research projects (aiming at a scientific
result) or service projects (aiming at providing a technology
or a routine data management and analysis).
Project proposals can be submitted to IZBI at any time. The projects
selected will be supported whenever possible with IZBI funds.
TheIZBI is structured into working groups. Working groups consist
of IZBI research staff members and scientists of the participating
institutes. They have regular meetings, discuss research results,
invite guests, discuss new project proposals, and conduct courses
and seminars.
Each working group is headed by a scientific coordinator, who
stimulates and coordinates these activities and also supervises
the advance of projects and of skills.
Working group 1 ("Data Base and Data Integration",
coordinator Prof. Rahm) focuses particularly on projects to design
and implement data warehouses for genomic and molecular data and
related annotations. As a methodological working group it links
with all other working groups.
Working group 2 ("Tissue Organisation", coordinator
Dr. Drasdo) focuses on understanding spatial tissue formation.
It pursues projects using simulation models and on 3D image reconstruction
of microscopy data.
Working group 3 ("Signal Transduction and Gene Expression",
coordinator Prof. Horn) has two areas of activity. One concerns
gene expression analysis. The second area concerns cellular signal
transduction.
The Junior Research Group ("Complex Regulatory Networks",
Prof. Bornholdt) is associated with WG3. This group studies dynamics
and function of complex regulatory network systems. Examples range
from the molecular level of gene regulation and signal transduction
networks, to cellular systems as the immune system and the brain.
The goal of this group is to develop methods, models, and strategies
for studying the dynamics of complex regulatory network systems.
Working Group 4 ("Genetic Evolution", coordinator
since 9/2002 Prof. Stadler) deals with phylogenies on the basis
of genome analyses.
Main results
The IZBI achieved the following results in 2003:
(1) The activities of the Bioinformatics Centre were positively
evaluated by a board of external reviewers in May 2003. The "Deutsche
Forschungsgemeinschaft" decided to support the Centre for
the next three years with a grant of 2.1 Mio Euro.
(2) IZBI starts cooperations with the following institutions
within the University of Leipzig:
Research Projects
Working group 1: Databases and Data Integration (WG1)
Data warehouse for gene expression analysis
E. Rahm (IfI), H. H. Do (IZBI), T. Kirsten (IZBI)
Annotation Management and Integration
E. Rahm (IfI), H. H. Do (IZBI), T. Kirsten (IZBI)
Working group 2: Tissue Organisation
3D Characterisation of Squamous Epithelial Carcinoma of the Uterine
Cervix by means of both Reconstructed and Modelled Tumours
J.-P. Kuska (IfI), J. Einenkel (Dept. of Gynaecology and Obstetrics),
M. Höckel (Dept. of Gynaecology and Obstetrics), L.-C. Horn
(Institute of Pathology), U.-D. Braumann (IZBI), J. Galle (IZBI),
H. Binder (IZBI), D. Drasdo (MPI MIS), M. Löffler (IMISE)
Modelling the effect of malfunctioning proliferation and apoptosis
on the growth dynamics of epithelial cell populations
J. Galle (IZBI), M. Löffler (IMISE), D. Drasdo (MPI MIS)
Modeling tumor growth in-vitro
D. Drasdo (MPI MIS), S. Höhme (IZBI)
Working group 3: Gene expression and cellular signal transduction
Application of the Westfall-Young testing strategy to several
sets of genes
J. Läuter (IZBI), M. Beck (IZBI), M. Löffler (IMISE)
Multivariate, parametric testing of differential gene expression
for Affymetrix GeneChipâ Data
E. Schuster (IMISE), I. Roeder (IMISE)
Sequence specific sensitivity of oligonucleotide probes
H. Binder (IZBI), I. Hofacker (Univ. Wien), T. Kirsten (IZBI),
M. Löffler (IMISE), P. Richter (IfI), P. Stadler (IfI)
Comparison of normalisation procedures for oligonucleotide micro-arrays
by parametric bootstrap simulation of spike-in experiments
J. Freudenberg (IZBI), H. Boriss (IZBI), D. Hasenclever (IMISE)
Comparison of summary measures and development of a present call
procedure based on 95% credible intervals using a 2 by 2 linear
model for signal synthesis
M. Engler (IZBI), H. Boriss (IZBI), D. Hasenclever (IMISE)
Meta analysis of gene expression studies
H. Boriss (IZBI), D. Hasenclever (IMISE)
Modelling the Transcriptional Control of Haemotaopoietic Commitment
D. Drasdo (MPI MIS), K. Missal (IZBI), M. Cross (IZKF)
Reconstruction of a transcriptional network controlling the interleukin-6-dependent
growth and survival of multiple myeloma cells
J. Jost (MPI MIS), A. Müller (MPI MIS), F. Horn (IKIT)
Working group 4: Genetic Evolution
Insights into recombination in humans
S. Ptak (IZBI), M. Przeworski (MPI EVA)
Metazoan deep phylogenies - can the Cambrian explosion be resolved
with molecular markers
G. Fritzsch (IZBI), M. Schlegel (Institute for Zoology)
Junior Research Group: Complex Regulatory Networks
Information processing in regulatory networks: Structure, dynamics,
and function
S. Bornholdt, K. Klemm (IZBI)
Interacting gene regulation networks and spatial pattern formation
S. Bornholdt, T. Rohlf (IZBI)
Complex Biological Networks in Autoimmune Diseases
S. Bornholdt, J. Reichardt (IZBI), P. Ahnert (IKIT)
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