Development of new polymeric biomaterials for in
vitro and in vivo liver reconstruction - LIVEBIOMAT (EU-Project)
(closed)
ENDOSYS
- Systems
Biology of Hepatocyte Endocytosis:
Within the Joint Research Project, the platform concept
Endocytosis-Systems Biology (Cell Biology-Systems Biology
successor project), the repolarization of primary murine
hepatocytes in a collagen sandwich in vitro could be
demonstrated over the course of 14 days. The mechanism of
endocytosis is also to be investigated in these repolarized
liver cells. The transfer of these results in mathematical
models and simulation platforms should shed light on the
relationship between endocytosis and signal transfer in
hepatocytes and enable the forecast of endocytotic and signaling
activities in hepatocytes. (BMBF)
(closed)