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Publikationen

2012

124. Czihal, P., Knappe, D., Fritsche, F. , Zahn, M., Berthold, N., Piantavigna, S., Müller, U., Van Dorpe, S., Herth, N., Binas, A., Köhler, G., De Spiegeleer, B., Martin, L. L., Nolte, O., Strater, N., Alber, G., Hoffmann, R. (2012) Api88 is a novel antibacterial designer peptide to treat systemic infections with multi-drug resistant Gram-negative pathogens. Chem. Biol. accepted.

123. Cook, S.L., Zimmermann, C.M., Singer, D., Fedorova, M., Hoffmann, R. & Jackson, G. P. (2012) Comparison of CID, ETD, and metastable atom-activated dissociation (MAD) of doubly- and triply-charged phosphorylated tau peptides. J. Mass Spectrom. accepted.

122. Dobslaff, K., Kreisig, T., Berthold, N., Hoffmann, R. Züchner, T. (2012) Novel peptide-protein assay for identification of antimicrobial peptides by fluorescence quenching. Anal. Bioanal. Chem. in press.

121. Todorovski, T., Fedorova, M. & Hoffmann, R. (2012) Identification of isomeric 5-hydroxytryptophan- and oxindolylalanine-containing peptides by mass spectrometry. J. Mass Spectrom., accepted.

120. Teuber, K., Fedorova, M., Hoffmann, R. & Schiller, J. (2012) 4-Dinitrophenylhydrazine as a new reactive Matrix to analyze oxidized Phospholipids by MALDI-TOF Mass Spectrometry. Anal. Lett. accepted.

116. Otvos, L., Haspinger, E., LaRussa, F., Maspero, F., Graziano, P., Kovalszky, I., Lovas, S., Nama, K., Hoffmann, R., Knappe, K., Cassone, M., Wade, J. and Surmacz, E. (2011) Design and Development of a Peptide-based Adiponectin Receptor Agonist for Cancer Treatment. BMC Biotechnology, 11 : 90. doi:10.1186/1472-6750-11-90 PMID: 21974986

115. Zauner, T., Berger-Hoffmann, R., Müller, K., Hoffmann, R. & Zuchner, T. (2011) Highly adaptable and sensitive protease assay based on fluorescence resonance energy transfer. Anal. Chem. 83 (19): 7356-63. PMID: 21892820

114. Todorovski, T., Fedorova, M. und Hoffmann, R. (2011) Mass spectrometric characterization of peptides containing different oxidized tryptophan residues. J. Mass Spectrom. 46: 1030-8. PMID:22012669

113. Bollineni, R.C., Hoffmann, R. & Fedorova, M. (2011) Identification of protein carbonylation sites by two-dimensional liquid chromatography in combination with MALDI- and ESI-MS. J. Prot . 74: 2338-50. PMID: 21777707

112: Shvartsburg, A., Singer, D., Smith, R. & Hoffmann, R. (2011) Ion Mobility Separation of Isomeric Phosphopeptides from a Protein with Variant Modification of Adjacent Residues. Anal. Chem. 83 (13):5078-85. PMID: 21667994

111: Bollineni, R.C., Fedorova, M. & Hoffmann, R. (2011) Identification of carbonylated peptides by tandem mass spectrometry using a precursor ion-like scan in negative ion mode. J. Prot., 74: 2351-9. PMID: 21669303

110. Kreisig T, Hoffmann R, Zuchner T (2011) Homogeneous Fluorescence-Based Immunoassay Detects Antigens Within 90 Seconds. Anal. Chem. 83 (11): 4281-7. PMID: 21495669

109. Xue, J., Rai, V., Singer, D., Chabierski, S., Xie, J., Reverdatto, S., Burz, D.S., Schmidt, A. M., Hoffmann, R. & Shekhtman A. (2011). Advanced Glycation End Product Recognition by the Receptor for AGEs. Structure 19 (5):722-732. PMID: 21565706

108. Wagner, C., Singer, D., Ueberschär, O., Stangner, T., Gutsche, C., Hoffmann, R. & Kremer, F. (2011). Dynamic force spectroscopy on the binding of monoclonal antibodies and tau peptides, Soft Matter , 2011,  7 , 4370-4378, DOI: 10.1039/C0SM01414A

107. Knappe, D., Zahn, M., Sauer, U., Schiffer, G., Sträter, N. & Hoffmann, R. (2011) Rational Design of Oncocin derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK-Complex. ChemBioChem, 12 (6):874-6. PMID: 21387510

106. Ermakova, I. I., Sakuta, G. A., Potekhina, M. A., Fedorova, M. A., Hoffmann, R . & Morozov, V. I. (2011) Major Chondroitin Sulfate Proteoglycans Identified in L6J1 Myoblast Culture. Biochemistry (Mosc), 76 : 359-65. PMID: 21568872

105. McCubbin, G.A., Praporski , S., Piantavigna, S.,  Knappe, D., Bowie, J.H., Separovic, F., Hoffmann, R. & Martin, L.L. (2011) QCM-D Fingerprinting of Membrane-Active Peptides, Eur. Biophys. J. 40 (4): 437-46, PMID: 211615233

104. Simeonov, P., Berger-Hoffmann, R., Hoffmann, R., Sträter, N. & Züchner, T. (2011) Surface supercharged human enteropeptidase light chain shows improved solubility and refolding yield. Protein Eng. Des. Sel. 24 (3): 261-8, PMID: 21084283

103. Todorovski, T., Fedorova, M., Hennig, L. & Hoffmann, R. (2011) Synthesis of peptides containing 5-hydroxytryptophan, oxindolylalanine, N-formylkynurenine and kynurenine, J. Pept. Sci. 17 (4): 256-62, PMID: 21254311

102. Otvos, Jr., L., Kovalszky, I., Scolaro, L., Sztodola, A., Olah, J., Cassone, M., Knappe, D., Hoffmann, R., Lovas, S., Hatfield, M.P.D., Beko, G., Zhang, S., Wade, J.D. & Surmacz, E. (2011). Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation. Peptide Science: 96 : 117–125 , PMID: 20564005.

2010

101. Knappe, D., Kabankov, N. & Hoffmann R. (2011) Bactericidal oncocin derivatives with superior serum stabilities. Int. J. Antimic. Agents 37(2):166-70. PMID: 21185160

100. Ostorhazi E, Rozgonyi F, Sztodola A, Harmos, F., Kovalszky, I. , Szabo, D., Knappe, D., Hoffmann, R., Cassone, M., Wade, J.D., Bonomo, R.A. & Otvos, L. (2010) Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections. J. Antimicr. Chemother. 65(11): 2416-2422. PMID: 20810424

99. Kuettner, E.B., Kettner, K., Keim, A., Svergun, D.I., Volke, D., Singer, D., Hoffmann, R., Müller, E.-C., Otto, A., Kriegel, T.M., Sträter, N. (2010) Crystal Structure of the Hexokinase KlHxk1 of Kluyveromyces lactis. A molecular basis to understand the control of yeast hexokinase functions via covalent modification and oligomerization. J. Biol. Chem. 2010 Dec 24; 285(52):41019-33. PMID: 20943665

98. Ehrlich, H., Deutzmann, R., Brunner, E., Cappellini, E., Koon, H., Solazzo, C., Yang, Y., Ashford, D., Thomas-Oates, J., Lubeck, M., Baessmann, C., Langrock, T., Hoffmann, R., Wörheide, G., Reitner, J., Simon, P., Tsurkan, M., Ereskovsky, A.V., Kurek, D., Bazhenov, V.V., Hunoldt, S., Mertig, M., Vyalikh, D.V., Molodtsov, S.L., Kummer, K., Worch, H., Smetacek, V. & Collins, M.J. (2010) Mineralization of the metre-long biosilica structures of glass sponges is templated on hydroxylated collagen. Nature Chem. 2(12) : 1084-1088. PMID: 21107374

97. Knappe, D., Piantavigna, S., Hansen, A., Mechler, A., Binas, A., Nolte, O., Martin, L.L., & Hoffmann, R. (2010) Oncocin (VDKPPYLPRPRPPRRIYNR-NH 2 ): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens. J. Med. Chem. 53 (14) : 5240-7. PMID: 20565063.

96. Singer, D., Kuhlmann, J., Muschket, M. & Hoffmann, R. (2010) Separation of mulitiphosphorylated peptide isomers by hydrophilic interaction chromatography on an aminopropyl phase. Anal. Chem. 82(15) : 6409-14.
Dazu folgender Link:  PMID: 20593796.

95.Knappe, D., Henklein, P., Hoffmann, R., Hilpert, K. (2010) Easy strategy to protect antimicrobial peptides for fast degradation in serum, Antimicrobial Agents and Chemotherapy (AAC), 54(9) : 4003-5. PMID: 20585128 .

94. Frolov, A. & Hoffmann, R. 2010 Identification and relative quantification of specific glycation sites in human serum albumin for type 2 diabetes mellitus in plasma. Anal Bioanal. Chem. 397(6) : 2349-2356. PMID: 20496030.

93. Fedorova, M., Todorovsky, T., Kuleva, N. & Hoffmann, R. (2010) Quantitative evaluation of tryptophan oxidation in actin and troponin I from skeletal muscles using a rat model of acute oxidative stress. Proteomics 10(14), 2692–2700 PMID: 20455213.

92. Fedorova, M., Frolov, A. & Hoffmann, R. (2010) Fragmentation behavior of Amadori-peptides obtained by non-enzymatic glycosylation of lysine residues with ADP-ribose in tandem mass spectrometry. J. Mass Spectrom 45(6): 664-9. PMID: 20527035.

91. Singer, D., Zauner, T., Genz, M., Hoffmann, R., Zuchner, T. (2010) Synthesis of pathological and non-pathological human exon 1 huntingtin. J. Pept. Sci. 16(7) : 358-63. PMID:20552561.

90. Fedorova, M., Kuleva, N., Hoffmann, R. (2010) Identification, quantification and functional aspects of skeletal muscle protein-carbonylation in vivo during acute oxidative stress. J. Proteome Res. 9(5): 2516-26. PMID:20377239 .

89. Birkenmeier,G., Stegemann, C., Hoffmann, R., Günther, R., Huse, K. & Birkemeyer, C. (2010) Posttranslational Modification of Human Glyoxalase 1 Indicates Redox-Dependent Regulation. Plos One 5(4): e10399. PMID: 20454679

88. Fedorova, M., Kuleva, N., Hoffmann, R. (2010). Identification of cysteine, methionine and tryptophan residues of actin oxidized in vivo during oxidative stress. J. Proteome Res. 9(3): 1598-609. PMID: 20063901.

87. Hanisch, K., Sininen, H., Alafuzoff, I., Hoffmann, R. (2010) Analysis of human Tau in cerebrospinal fluid. J. Proteome Res. 9(3): 1476-82. PMID: 20067323.

86. Stegemann, C., Tsvetkova, E. V., Aleshina, G. M., Lehrer, R. I., Kokryakov, V. N.& Hoffmann, R. (2010)
De-novo sequencing of two new cyclic beta-defensins from baboon ( Papio hamadryas ) leukocytes by ma trix-assisted laser desorption/ionization mass spectrometry. Rapid Commun. Mass Spectrom. 24(5): 599-604. PMID: 20155756.

85. Ehrlich, H., Hanke, T., Simon, P., Born, R., Fischer, C., Frolov, A., Langrock, T., Hoffmann, R., Schwarzenbolz, U., Henle, T. Bazhenov, V.V., Worch H. (2010). Carboxymethylation of the fibrillar collagen with respect to formation of hydroxyapatite. J. Biomed. Mat. Res. B Appl Biomater. 2009 Dec 2; 92 (2): 542-54. PMID: 19957363.

2009

84. Singer, D, Soininen, H., Alafuzoff, I., Hoffmann, R. 2009. Immuno-PCR-based quantification of multiple phosphorylated tau-epitopes linked to Alzheimer's disease. Anal. Bioanal. Chem. (2009) 395:2263-2267. PMID: 19821112.

83. Zuchner, T., Schumer, F. Berger-Hoffmann, R., Müller, K., Lukas, M. Zeckert, K., Marx, J., Hennig, H. & Hoffmann, R. 2009. Highly sensitive protein detection based on lanthanide chelates with antenna ligands providing a linear range of five orders of magnitude. Anal. Chem. 2009 Nov 15; 81 (22): 9449-53. PMID:19817408.

82. Fedorova, M., Kuleva, N. & Hoffmann, R. 2009. Reversible and irreversible modifications of skeletal muscle proteins in a rat model of acute oxidative stress. Biochim. Biophys. Acta. 2009 Dec; 1792 (12): 1185-93. PMID: 19786098.

81. Vikhoreva, N.N., Vikhorev, P.G. Fedorova, M., Hoffmann, R. & Kuleva, N. 2009 The in vitro motility parameters of actin filaments from Mytilus edulis exposed in vivo to copper ions Arch. Biochem. Biophys. 2009 Nov; 491 (1-2): 32-8. PMID: 19796626.

80. Nielsen-Marsh, C.M., Stegemann, C., Hoffmann, R., Smith, T., Feeney, R., Toussaint, M., Harvati, K., Panagopoulou, E. & Hublin,J.-J., Richards, M.P. 2009 Extraction and sequencing of human and Neanderthal mature enamel proteins using MALDI-TOF/TOF MS. J. Archaeol. Sci. 36: 1758-63.

79. Czihal, P. & Hoffmann, R. 2009 Mapping of apidaecin regions relevant for antimicrobial activity and bacterial internalization. Int. J. Pept. Res. Ther., 15: 157-164 http://www.springerlink.com/content/1573-3149 .

78. Piantavigna, S., Czihal, P., Mechler, A., Richter, M., Hoffmann, R. & Martin, L.L. 2009 Cell penetrating Apidaecin peptides exhibit thresholded interactions with biomimetic phospholipid membranes, Int. J. Pept. Res. Ther.15: 139-146 http://www.springerlink.com/content/1573-3149 .

77. Stegemann, C., Kolobov, A. Jr., Leonova, Y.F., Knappe, D., Shamova, O., Ovchinnikova, T.V., Kokryakov, V.N. & Hoffmann, R. (2009) Isolation, purification and de novo sequencing of TBD-1, the first beta-defensin from leukocytes of reptiles. Proteomics 9: 1364-73. PMID: 19253295

76. Shamova, O., Orlov, D., Stegemann, C., Czihal, P., Hoffmann, R., Brogden, K., Kolodkin, N.,  Sakuta, G., Tossi, A.,  Sahl, H.-G., Kokryakov, V. & Lehrer, R. (2009) ChBac3.4: A novel proline-rich antimicrobial peptide from goat leukocytes. Int. J. Pept. Res. Ther. 15: 31-42 http://www.springerlink.com/content/1573-3149 .

75. Ehrlich, H., Hanke, T., Frolov, A., Langrock, T., Hoffmann, R., Fischer, C., Schwarzenbolz, U., Henle, T., Born, R. & Worch, H. (2009) Modification of Collagen in vitro with respect to formation of  N^e-Carboxymethyllysine. Int. J. Biol. Macromol.,44: 51-56.PMID: 18984004.

2008

74. Andreazza, H.J., Fitzgerald, M., Bilusich, D., Hoffmann, R., Hoffmann, P., Eichinger, P.C. & Bowie, J.H. (2008) Characteristic negative ion fragmentations of deprotonated peptides containing post-translational modifications: mono-phosphorylated Ser, Thr and Tyr. A joint experimental and theoretical study. Rapid Commun. Mass Spectrom. 22: 3305-12. PMID: 18821730.

73. Singer D & Hoffmann R. (2008) Synthesis of O-phosphopeptides on solid phase. Methods Mol. Biol. 494: 209-222.PMID: 18726576.

72. Frolov, A. & Hoffmann R. (2008) Separation of Amadori peptides from their unmodified analogs in ion-pairing RP-HPLC with heptafluorobutyric acid as ion-pair reagent. Anal. Bioanal. Chem., 392(6):1209-14. PMID: 18813915.

71. Stegemann, C. & Hoffmann, R. (2008) Sequence analysis of antimicrobial peptides sequence analysis of antimicrobial peptides by tandem mass spectrometry. Methods Mol Biol. 494: 31-46. PMID:18726567.

70. Xie, J., Reverdatto, S., Frolov, A., Hoffmann, R., Burz, D.S. & Shekhtman A. (2008) Structural Basis for Pattern Recognition by the Receptor for Advanced Glycation End Products (RAGE), Journal of Biological Chemistry, 283: 27255-69. PMID: 18667420.

69. Ehrlich, H., Hanke, T., Born, R., Fischer, C., Frolov, A., Langrock, T., Hoffmann, R., Schwarzenbolz, U., Henle, T., Simon, P., Geiger, D., Bazhenov, V.V. & Worch, H. (2008) Mineralization of biomimetically carboxymethylated collagen fibrils in a model dual membrane diffusion system. J. Membrane Sci., Journal of Membrane Science 326 (2009) 254--259.
.

68. Volke, D. & Hoffmann, R. (2008) Quantitative Proteomics by Fluorescent Labeling of Cysteine Residues using a Set of Two Cyanine-based or Three Rhodamine-based Dyes. Electrophoresis, 29(22):4516-4526. PMID: 19035404.

67. Knappe, D., Otvos, L., De Pascali, F., Cassone, M., Scolaro, L., Abbadessa, G., Carillo-Infante, C., Kiani, M., Donelson, F., Hoffmann, R. & Surmacz, E. (2008) Drug development-targeted screening of leptin agonist glycopeptides. Int. J. Pept. Res. Ther.14: 247-254 http://www.springerlink.com/content/1573-3149 .

66. Morell, M., Czihal, P., Hoffmann, R., Otvos, L., Avilés, F.X. & Ventura, S (2008) Monitoring the interference of protein-protein interactions in vivo by bimolecular fluorescence complementation (BIFC): the DnaK case. Proteomics, 8(17): 3433-42, PMID: 18686297.

65. Muetzelburg, M.V. & Hoffmann, R. (2008). Separation of multiphosphorylated peptide isomers by capillary zone electrophoresis, Electrophoresis, 21: 4381-5, PMID: 18942677.

64. Otvos, L., Terrasi, M., Cascio, S., Cassone, M., Abbadessa, G., di Pascali, F., Scolaro, L., Knappe, D., Stawikowski, M., Cudic, P., Wade, J.D., Hoffmann, R. & Surmacz, E. (2008). Development of a Pharmacologically Improved Peptide Agonist of the Leptin Receptor, Biochimica et Biophysica Acta, 1783: 1745-54.PMID: 18555805.

63. Singer, D., Herth, N., Kuhlmann, J., Holland-Nell, K., Beck-Sickinger, A.G. & Hoffmann, R. (2008). Mapping of phosphorylation-dependent anti-tau monoclonal antibodies in immunoblots using human tau-constructs synthesized by native chemical ligation. Biochem. Biophys. Res. Comm., 367(2): 318-22. PMID: 18162172

62. Frolov, A. & Hoffmann, R. (2008). Analysis of Amadori peptides enriched by boronic acid affinity chromatography, Ann. N. Y. Acad. Sci., 1126: 253-6. PMID: 18448825

61. Kunert, A. Losse, J., Gruszin, C., Hühn, M., Kändler, K., Mikkat, S., Volke, D., Hoffmann, R., Jokiranta, T.S., Seeberger, H., Möllmann, U., Hellwage, J. & Zipfel, P.F. (2007). Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a Factor H and plasminogen-binding protein. J. Immunol. 179 (5): 2979-88 . PMID: 17709513

60. Frolov, A., Singer, D. & Hoffmann, R. (2007). Solid-phase synthesis of glucose-derived. Amadori peptides. J. Pept. Sci., 13: 862-867. PMID: 17883244

59. Lepetit, B., Volke, D., Szabo, M., Hoffmann, R., Garab, G., Wilhelm, C. & Goss, R. (2007). Spectroscopic and molecular characterization of the oligomeric antenna of the diatom Phaeodactylum tricornutum. Biochemistry 46 (34): 9813-22 . PMID: 17672483

58. Porzig, R., Singer, D. & Hoffmann, R. (2007). Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein.Biochem. Biophys. Res. Comm. 358: 644-649. PMID: 17499212

57. Kellner, H., Jehmlich, N., Benndorf, D., Hoffmann, R., Rühl, M., Hoegger, P.J., Majcherczyk, A., Kües, U., von Bergen, M. & Buscot, F. (2007); Detection, quantification and identification of fungal extracellular laccases using polyclonal antibody and mass spectrometry.  Enzyme and Microbial Technology 41 694-701 .

56. Sykora, C., Hoffmann, R. & Hoffmann, P. (2007). Enrichment of multiphosphorylated peptides by immobilized metal affinity chromatography using Ga(III)- and Fe(III)-complexes. Prot. Pept. Lett., 14: 489-496. PMID: 17584176

55. Zhang, Q., Frolov, A., Tang, N., Hoffmann, R., van de Goor, T.O. & Smith, R.D. (2007). Application of electron transfer dissociation mass spectrometry in analyses of non-enzymatically glycated peptides. Rapid Commun. Mass. Spectrom. 21, 661-666. PMID: 17279487

54. Langrock, T., García-Villar, N. & Hoffmann, R. 2007. Analysis of Hydroxyproline by Reversed-Phase HPLC and Mass Spectrometry. J. Chromatogr. B. 847: 282-288.

53.Frolov, A., Hoffmann, P. & Hoffmann, R. (2006). Fragmentation behavior of glycated peptides derived from D-glucose, D-fructose and D-ribose in tandem mass spectrometry. J. Mass Spectrom., 41 (11): 1459-1469 PMID: 17063450

52. Singer, D., Lehmann, J., Hanisch, K., Härtig, W. und Hoffmann R. (2006). Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease. Biochem. Biophys. Res. Comm., 346 (3): 819-28, PMID:16781671

51. Volke, D. & Hoffmann, R. (2006). Purification of bovine Tau versions by affinity chromatography. Prot. Expr. Purif., 50: 37-42, PMID: 16750637

50. Härtig, W., Lehmann, J., Stieler, J., Singer, D., Grosche, J., Arendt, T. & Hoffmann, R. (2006). Simultaneous detection of tau phospho-epitopes with haptenylated antibodies. NeuroReport, 17 (9) : 869-874, PMID: 16738478

49. Volke, D. & Hoffmann, R. (2006). Characterization of bovine Tau-preparations by two-dimensional gel electrophoresis. Prot. Pept. Lett., 13 (6): 617-625, PMID:16842118

48. Cook, J.R., Lee, J.-H., Yang, Z.H., Krause, C.D., Herth, N., Hoffmann, R. & Pestka, S. (2006) FBXO11/PRMT9, a new protein arginine methyltransferase, symmetrically dimethylates arginine residues. Biochem. Biophys. Res. Commun. 342 (2): 472-81 PMID: 16487488

47. Langrock, T., Czihal, P. & Hoffmann, R. (2006). Amino acid analysis by hydrophilic interaction chromatography coupled on-line to electrospray ionization mass spectrometry. Amino Acids, 30: 291-7, PMID: 16622599

46. Frolov, A., Singer, D. & Hoffmann, R. (2006). Site-Specific Synthesis of Amadori-Modified Peptides on Solid Phase. J. Pept. Sci., 12: 389-95, PMID: 16342332

45. Singer, D., Volke, D. & Hoffmann, R. (2005). Characterization of phosphorylation-dependent anti-Tau antibodies. J. Pept. Res. Ther., 11: 279-289.

44. Otvos, L. Jr, Wade, J.D., Lin, F., Condine, B.A., Hanrieder, J. & Hoffman, R. (2005). Designer antibacterial peptides kill fluoroquinolone-resistant clinical isolates. J. Med. Chem., 48: 5349-59. PMID: 16078852

43. Lee, J.H., Cook, J.R., Yang, Z.H., Mikrochnitchenko, O., Gunderson, S., Felix, A.M., Herth, N. Hoffmann, R. & Pestka, S. (2005). PRMT7: A new protein arginine methyltransferase that synthesizes symmetric dimethylarginine. J Biol Chem., 280: 3656-64.PMID: 15494416

42. Chie, L., Cook, J.R., Chung, D., Hoffmann, R., Yang, Z., Kim, Y., Pestka, S. & Pincus, M.R. (2003). A protein methyl transferase, PRMT5, selectively blocks oncogenic ras-p21 mitogenic signal transduction. Ann Clin Lab Sci., 33: 200-207. PMID: 12817625

41. Bencivengo, A.M., Cudic, M., Hoffmann, R. & Otvos, L. (2003). The efficacy of the antibacterial peptide, pyrrhocoricin, is finely regulated by its amino acid residues and active domains. Lett. Pept. Sci., 8: 201-209. www.springerlink.com

40. Franken, S., Junghans, U., Roßlenbroich, V., Baader, S.L., Hoffmann, R., Gieselmann, V., Viebahn, C. & Kappler, J. (2003). Collapsin response mediator proteins of neonatal rat brain interact with chrondroitin sulfate. J. Biol. Chem. 278: 3241-50. PMID: 12444086

39. Kragol, G., Hoffmann, R., Chattergoon, M.A., Lovas, S., Cudic, M., Bulet, P., Condie, B.A., Rosengren, K.J., Montaner, L.J., & Otvos, L., Jr. (2002). Eur. J. Biochem. Identification of crucial residues for the antibacterial activity of the proline rich peptide, pyrrhocoricin. 269: 4226-4237 PMID: 12199701

38. Pipkorn, R., Boenke, C., Gehrke, M. & Hoffmann, R. (2002). High-throughput peptide synthesis and peptide purification strategy at the low micromol-scale using the 96-well format. J. Pept. Res. 59: 105-114. PMID: 11985704

37. Wehofsky, M. & Hoffmann, R. (2002). Automated isotopic deconvolution and deisotoping of electrospray mass spectra. J. Mass Spectrom., 37: 223-229. PMID: 11857767

36. Hoffmann, R., Wehofsky, M. & Metzger, S. (2001). Neutral loss und parent ion analysis in MALDI-MS using an ion-gate scanning mode. Anal. Chem., 73: 4845-4851. PMID: 11681460

35. Pfeifer, T., Klaus, U., Hoffmann, R. & Spiteller, M. ((2001)) Characterization of humic substances using atmospheric pressure chemical ionization and electrospray ionisation mass spectrometry combined with size-exclusion chromatography. J. Chrom. A, 926: 151-159. PMID: 11554407

34. Kragol, G., Lovas, S., Varadi, G., Condie, B.A., Hoffmann, R. & Otvos, L. Jr. (2001). The Antibacterial Peptide Pyrrhocoricin Inhibits the ATPase Actions of DnaK and Prevents Chaperone Assisted Protein Folding. Biochemistry, 40: 3016-3026. PMID: 11258915

33. Wehofsky, M., Hoffmann, R., Hubert, M. & Spengler, B. (2001). Isotopic deconvolution of MALDI-mass specvtra for substance-class specific analysis of complex samples. Eur. J. Mass Spectrom., 7: 39-46. www.impub.co.uk/abs/EMS07_0039.html

32. Metzger, S. & Hoffmann, R. (2000). Studies on the dephosphorylation of phosphotyrosine-containing peptides during the post-source decay in MALDI. J. Mass Spectrom., 35: 1165-1177. PMID: 11110089

31. Daly, N.L., Hoffmann, R. Otvos, L. Jr. & Craik, D.J. (2000) The role of phosphorylation in the conformation of t peptides implicated in Alzheimer‘s disease. Biochemistry 39: 9039-9046. PMID: 10913317

30. Kappler, J., Franken, S., Junghans, U., Hoffmann, R., Linke, T., Müller, H.W. & Koch, K.-W. (2000) Glycosaminoglycan-binding properties and secondary structure of the C-terminus of Netrin-1. Biochem. Biophys. Res. Commun., 271: 287-291. PMID: 10799289

29. Otvos, L. Jr., Bokonyi, K., Varga, I., Otvos, B.I., Hoffmann, R., Ertl, H.C.J., Wade, J.D., McManus, A.M., Craik, D.J. & Bulet, P., Jr. (2000). Insect peptides with improved protease-resistance protect mice against bacterial infection. Protein Sci, 9: 742-749. PMID: 10794416

28. Otvos, L. Jr., Pease, A.M., Bokonyi, K., Giles-Davis, W., Rogers, M.E., Hintz, P.A., Hoffmann, R. & Ertl, H.C.J. (2000). In situ stimulation of a T helper cell hybridoma with a cellulose-bound peptide antigen. J. Immunol. Meth., 233: 95-105. PMID: 10648860

27. Desimone, M., Krüger, M., Wessel, T., Wehofsky, M., Hoffmann, R. & Wagner, E. (2000). Purification and characterization of an aminopeptidase from the chloroplast stroma of barley leaves by chromatographic and electrophoretic methods. J. Chromatogr. B 737: 285-293. PMID: 10681066

26. Cudic, M., Bulet, P., Hoffmann, R., Craik, D.J. & Otvos, L. Jr. (1999). Chemical synthesis, antibacterial activity and conformation of diptericin, an 82-mer peptide originally isolated from insects. Eur. J. Biochem. 266: 549-558. PMID: 10561597

25. Hoffmann, R., Metzger, S., Spengler, B. & Otvos, L., Jr. (1999). Sequencing of peptides phosphorylated on serines and threonines by post-source decay in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Mass Spectrom. 34: 1195-1204. PMID: 10548813

24. Hoffmann, R., Craik, D.J., Bokonyi, K., Varga, I. & Otvos, L., Jr. (1999). High level of aspartic acid-bond isomerization during the synthesis of an N-linked t glycopeptide. J. Peptide. Res. 5: 442-456. PMID: 10580643

23. Ctortecka, B., Tröger, W., Mallion, S., Butz, T., Hoffmann, R. & the ISOLDE-Collaboration, Jr. (1999). Hg coordination studies of oligopeptides containing cysteine, histidine and tyrosine by 199mHg TDPAC. Hyperfine Interactions 120/121: 737-743.

22. Hoffmann, R., Bulet, P., Urge, L. & Otvos, L., Jr. (1999). Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects. Biochim. Biophys. Acta 1426: 459-67. PMID: 10076062

21. McManus, A.M., Otvos, L., Jr., Hoffmann, R. & Craik, D. (1999). Conformational studies by NMR of the anti-microbial peptide, drosocin and its non-glycosylated derivative: effects of glycosylation on solution conformation. Biochemistry, 38: 705-714. PMID: 9888811

20. Hoffmann, R., Craik, D.J., Pierens, G., Bolger, R.E. & Otvos, L., Jr. (1998). Phosphorylation of the C-terminal sites of human p53 reduces non-sequence specific DNA binding as modeled with synthetic peptides. Biochemistry 37: 13755-13764. PMID: 9753464

19. Otvos, L. Jr., Hoffmann, R., Xiang, Z.Q., O, I., Deng, H., Wysocka, M., Pease, A.M., Rogers, M.E., Blaszczyk Thurin, M. & Ertl, H.C.J. ((1998)) A monoclonal antibody to a multiphosphorylated, conformational epitope at the carboxy terminus of p53. Biochem. Biophys. Acta 1404: 457-474. PMID: 9739174

18. Otvos. L. Jr., Pease, A.M., Wade, J.D. & Hoffmann, R. ((1998)) N glycosylation of the fourth repeat of human Tau protein abolishes binding to the C terminal acidic Tau binding segment of ß tubulin. Prot. Pept. Lett. 5: 207-213.

17. Hoffmann, R., Bril, G. & Otvos, L. Jr. (1998). Prediction of retention times of peptide nucleic acids during reversed-phase high performance liquid chromatography. J. Chromatogr. A, 814: 111-119. PMID: 9718690

16. Tholey, A. & Hoffmann, R. (1997). Solid phase synthesis of tyrosyl H-phosphonopeptides and methyl-phosphonopeptides. J. Peptide Sci. 3: 186-192. PMID: 9230484

15. Jicha, G.A., Lane, E., Vincent, I., Otvos, L. Jr., Hoffmann, R. & Davies, P. (1997). A conformation and phosphorylation dependent antibody recognizing the paired helical filaments of Alzheimer's disease. J. Neurochem. 69: 2087-2095. PMID: 9349554

14. Hoffmann, R., Segal M. & Otvos, L., Jr. (1997). Separation of sets of mono- and diphosphorylated peptides by reversed-phase high performance liquid chromatography. Analytica Chimica Acta 352: 327-333 SienceDirect

13.Hoffmann, R., Vasko M. & Otvos, L., Jr. (1997). Serum stability of phosphopeptides. Analytica Chimica Acta 352: 319-325 SienceDirect

12. Hoffmann, R., Lee, V. M.-Y., Leight, S., Varga, I. & Otvos, L. Jr. (1997). Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites. Biochemistry 36: 8114-8124. PMID: 9201960

11. Hoffmann, R., Dawson, N.F., Wade, J.D. & Otvos, L., Jr. (1997). Oxidized and phosphorylated synthetic peptides corresponding to the second and third tubulin-binding repeats of the Tau protein reveal structural features of paired helical filaments assembly. J. Peptide Res. 50: 132-142. PMID: 9273897

10. Hoffmann, R., Hoffmann, T., Tholey, A. & Kalbitzer, H.R. (1997). Synthesis and NMR-spectroscopy of peptides containing either phosphorylated or phosphonylated cis- or trans-4-hydroxy-L-proline. J. Peptide Res. 49, 163-173. PMID: 9147312

9. Troeger, W., Lippert, C., Schmidt, P., Schmidt, U., Butz, T., Hoffmann, R., Zeppezauer, M. & the ISOLDE Collaboration. (1996). Hg-coordination studies of cysteine containing oligopeptides. Z. Naturforsch. 51a: 427-430.

8. Hoffmann, R. & Otvos, L., Jr. (1996). Selective dimerization of cysteines in glycopeptides and phosphopeptides. Lett. Pept. Sci. 3: 371-377. www.springerlink.com

7. Hoffmann, R., Tholey, A., Hoffmann, T. & Kalbitzer, H.R. (1996). Solid-phase synthesis of H- and methyl-phosphonopeptides. Int. J. Peptide Protein Res. 47: 245-253. PMID: 8738649

6. Schneider, K.H., Jakel, G., Hoffmann, R. & Giffhorn, F. (1995). Enzyme evolution in Rhodobacter sphaeroides: Selection of a mutant expressing a new galactitol dehydrogenase and biochemical characterization of the enzyme. Microbiology 141: 1865-1873. PMID: 7551050

5. Berger, R.G., Hoffmann, R., Zeppezauer, M., Wagner-Redeker, W., Maljers, L., Ingendoh, A. & Hillenkamp, F. (1995). Separation and characterization of bovine histone H1 subtypes by combined ion-exchange and reversed-phase chromatography and mass spectrometry. J. Chromatogr. A, 711: 159-165. PMID: 7496487

4. Hoffmann, R. , Wachs, W.O., Berger, R.G., Kalbitzer, H.R., Waidelich, D., Bayer, E., Wagnerredeker, W. & Zeppezauer, M (1995). Chemical phosphorylation of the peptides GGXA (X=S,T,Y): An evaluation of different chemical approaches. Int. J. Peptide Protein Res. 45: 26-34. PMID: 7775006

3. Hoffmann, R., Reichert, I., Wachs, W.O., Zeppezauer, M. & Kalbitzer, H.R. (1994). 1H and 31P NMR spectroscopy of phosphorylated model peptides. Int. J. Peptide Protein Res. 44: 193-198. PMID: 7529751

2. Zeppezauer, M., Hoffmann, R., Schönberger, A., Rawer, S., Rapp, W. & Bayer, E. (1993). Hydrophilic-polystyrene-polyoxyethylene graft polymer beads as carrier of antigenic peptides for in vivo and in vitro immunization techniques: Applications to the non-catalytic zinc loop of HLADH isozymes and to histone fragments. Z. Naturforsch. 48b: 1801-1806.

1. Wolber, V., Rensland, H., Brandmeier, B., Sagemann, M., Hoffmann, R., Kalbitzer, H.R. & Wittinghofer, A. 1992. Expression, purification, and biochemical characterization of the human immunodificiency virus 1 nef gene product. Eur. J. Biochem. 205: 1115-1121. PMID: 1533585