Centre d’Etudes Nucléaire de Bordeaux Gradignan
University of Bordeaux
The CENBG is a laboratory (UMR5797) of the Bordeaux 1 University and CNRS/IN2P3 involved in fundamental nuclear physics and accelerator based interdisciplinary research. The group Interface Physique-Biologie has a long-term expertise in the application of ion microbeam techniques to biomedical research. The CENBG microbeam line became operational in 1989. Since then, it was used in the frame of cell biology studies: cellular pharmacology and cancer research (uptake of anticancer drugs, cisplatin and iodo-deoxydoxorubicin, in resistant human cell lines, metal balance in human neuroblastoma cell lines, kinetics of chemotherapeutic drugs in tumor nodules to improve modes of administration) - pathology (pathogenesis of a new muscular pathology: macrofage myofasciitis) - physiology of human experimental models: elucidation of ionic pathways in combination with electro-physiological techniques (the human amniotic membrane, allantochorial placental vessels, ionic balance in human skin). In addition to ion beam microanalytical facilities, cell culture and preparation labs are available with instrumentation for cryotechniques (cryomicrotome).
CENBG’s homepage: http://www.cenbg.in2p3.fr