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Research Focus Areas
Natural product chemistry and bioorganic chemistry:
- Lipid metabolism: synthesis and biological investigations of scyphostatin and ceramide analogues as sphingomyelinase inhibitors
- Cell signaling; receptor tyrosin kinases (RTK)s; novel inhibitors of RTKs
- Sialic acid biosynthesis: carbon hydrate analogues as inhibitors of the sialic acid biosynthesis
- Development of histon deacetylase and histon acetyltransferase modulators
- Polymer bounded reagents and novel oxidizing agents (hypervalent iodine compounds)
- Assays for estimation of biological activity: chorio-allantoic membrane (CAM) assay; cell proliferation and migration assay (HUVEC); sphingomyelinase assay; apoptosis; RTK-ELIAs like VEGF-R (flt-4 and KDR), EGF-R, Erb2-R, Ti2, IGF1-R
- Kinesin inhibitors
- Bioactive alkaloids
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