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Honorarprofessor Dr. Joachim Mittendorf



Curriculum Vitae
Patents
  Contact Information:
BAYER Schering Pharma AG
Pharma Research
D-42096 Wuppertal

Tel.:  +49 (0) 2 02 36-43 52
Fax:  +49 (0) 2 02 36-44 90
E-Mail: joachim.mittendorf@bayerhealthcare.com
Publications
  1. Mittendorf, J. Liebigs Ann. Chem. 1988, 1201:
    Enantioselective synthesis of (R)- and (S)- 4-methylcycloserine by the bislactim ether method.
  2. Schöllkopf, U.; Mittendorf, J. Angew. Chem. 1989, 101, 633:
    From 2,5-dihydropyrazines to 2H-1,4-diazepines, and from benzodihydroarenes to benzocycloheptene derivatives, structural variants of the antidepressant protriptylene.
  3. Hartwig, W.; Mittendorf, J. Synthesis 1991, 939:
    Enantioselective synthesis of 2,3-diamino acids by the bislactim ether method.
  4. Boese, R.; Green, J. R.; Mittendorf, J.; Mohler, D. L.; Vollhardt, K. P. C.: Angew. Chem. 1992, 104, 1643:
    The first hexabutadiynylbenzene derivative: synthesis and structure.
  5. Schmidt, U.; Schumacher, A.; Mittendorf, J.; Riedl, B. Journal of Peptide Research 1998, 52, 143:
    Contribution to the synthesis of aureobasidin A. Synthesis of cyclopeptolides containing the sequence leucyl-N-methyl- -hydroxyvalyl-(2R)-oxy-(3R)-methyl-pentanoic acid.
  6. Hartwig, W.; Mittendorf, J Encyclopedia of Reagents for Organic Synthesis 2001:
    (2S)-(+)-2,5-Dihydro-2-isopropyl-3,6-dimethoxypyrazine.
  7. Mauler, F.; Mittendorf, J.; Horváth, E.; De Vry, J. Journal of Pharmacology and Experimental Therapeutics 2002, 302, 359:
    Characterization of the diarylether sulfonylester (-)-(R)-3-(2-hydroxymethylindanyl-4-oxy)phenyl-4-4-4-trifluoro-1-sulfonate (BAY 37-7271) as a potent cannabinoid receptor agonist with neuroprotective properties.
  8. Steinhagen, H.; Gerisch, M.; Mittendorf, J.; Schlemmer, K.-H.; Albrecht, B. Biorg. Med. Chem. Lett. 2002, 12, 3187 :
    Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
  9. Mittendorf, J: Benet-Buchholz, J.; Fey, P. Mohrs, K.-H. Synthesis 2003, 136:
    Efficient asymmetric synthesis of -amino acid BAY 10-8888 / PLD-118, a novel antifungal for the treatment of yeast infections.
  10. Mittendorf, J; Kunisch, F.; Matzke, M.; Militzer, H.-C.; Schmidt, A.; Schoenfeld, W. Biorg. Med. Chem. Lett. 2003, 13, 433:
    Novel antifungal -amino acids: Synthesis and activity against Candida albicans.
  11. Kuhl A; Hahn M G; Dumic M; Mittendorf J. Amino Acids 2005, 29, 89:
    Alicyclic beta-amino acids in Medicinal Chemistry.
  12. Hasenoehrl A.; Galic T.; Ergovic G.; Marsic N.; Skerlev M.; Mittendorf J.; Geschke U.; Schmidt A.; Schoenfeld W. Antimicrobial agents and chemotherapy 2006, 50, 3011:
    In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans.
  13. Kast R; Schirok H; Figueroa-Perez S; Mittendorf J; Gnoth M J; Apeler H; Lenz J; Franz J K; Knorr A; Hutter J; Lobell M; Zimmermann K; Munter K; Augstein K H; Ehmke H; Stasch J P British Journal of Pharmacology 2007, 152, 1070:
    Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase.
  14. Schermuly R.; Stasch J.-P.; Pullamsetti S. S.; Middendorff R.; Mueller D.; Schlüter K.-D.; Dingendorf A.; Kolosionek E.; Kaulen C.; Dumitrascu R.; Weissmann N.; Mittendorf J.; Klepetko W.; Seeger W.;, Ghofrani H. A.; Grimminger F. Eur. Respir. J. 2008, 32, 881-891:
    Expression and Function of Soluble Guanylate Cyclase in Pulmonary Arterial Hypertension.
  15. Schirok, H.; Kast, R.; Figueroa-Perez, S.; Bennabi, S.; Gnoth, M. J.; Feurer, A.; Heckroth, H.; Thutewohl, M.; Paulsen, H.; Knorr, A.; Huetter, J.; Lobell, M.; Muenter, K.; Geiss, V.; Ehmke, H.; Lang, D.; Radtke, M.; Mittendorf, J.; Stasch, J.-P. ChemMedChem 2008, 3, 1893-1904:
    Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors.
  16. Mittendorf, J.; Weigand S.; Alonso-Alija C.; Bischoff E.; Feurer A.; Gerisch M.; Kern A.; Knorr A.; Lang D.; Muenter K.; Radtke M.; Schirok H.; Schlemmer K.-H.; Stahl, E.; Straub A.; Wunder F.; Stasch J.-P. ChemMedChem 2009, accepted.
Last Update: 17.02.08