Approach and Methodology

• Genetic approaches complemented by biochemical methods, in combination with functional assays or mass spectroscopy.
• Advanced light microsocopic techniques to obtain dynamic information of activities of motors and their regulators.
• Chemical genetics to perturb the function of molecular motors specifically and to identify kinase substrates.
• Chemical synthesis of small molecule libraries together with chemical library screens to identify small molecule inhibitors in order to generate tools for mitosis research.
• Theoretical modelling to integrate the experimental information and to achieve a more global and moreover quantitative understanding of cell division.