Universität Leipzig

Paul-Flechsig-Institut für Hirnforschung
 
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Publikationen der Abteilung

Molekulare und zelluläre Mechanismen der Neurodegeneration

Publikationen, Bücher und Patente : Molekulare und zelluläre Mechanismen  der Neurodegeneration
2011| 2010| 2009| 2008| 2007| 2006| 2005| 2004| 2003| 2002| 2001| | 2000| 1999| 1998|

2011

Alexandru A, Jagla W, Graubner S, Becker A, Bauscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Ronicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU, von Hörsten S Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aß Is Induced by Pyroglutamate-Aß Formation. J Neurosci 2011; 31(36): 12790-12801
Alpar A, Ueberham U, Lendvai D, Naumann N, Rohn S, Gati G, Arendt T, Gärtner U Activity-induced dendrite and dendritic spine development in human amyloid precursor protein transgenic mice. Int J Dev Neurosci 2011; 29(2): 107-114
Hartlage-Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, Cynis H, Schilling S, Schliebs R, Demuth HU, Rossner S Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aß deposits in hippocampus via distinct cellular mechanisms. Acta Neuropathol 2011; 121: 705-719
Morawski M, Schulz I, Zeitschel U, Blosa M, Seeger G, Rossner S Role of Prolyl Oligopeptidase in Intracellular Transport and Protein Secretion. CNS Neurol Disord Drug Targets 2011; 10: 327-332
Nacmias B, Reitz C, Arendt T Early clinical and molecular detection of Alzheimer's disease. Int J Alzheimers Dis 2011; 2011: e818639
Penttinen A, Tenorio-Laranga J, Siikanen A, Morawski M, Rossner S, Garcia-Horsman JA Prolyl Oligopeptidase: A Rising Star on the Stage of Neuroinflammation Research CNS & Neurological Disorders - Drug Targets 2011; 10: 340-348
Reinert A, Mittag A, Reinert T, Tarnok A, Arendt T, Morawski M On the quantification of intracellular proteins in multifluorescence-labeled rat brain slices using slide-based cytometry. Cytometry A 2011; 79(6): 485-491
Salkovic-Petrisic M, Osmanovic-Barilar J, Brückner MK, Hoyer S, Arendt T, Riederer P Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer\'s disease: a long-term follow up study. J Neural Transm 2011; 118(5): 765-772
Schilling S, Kohlmann S, Bauscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Horsten S, Rossner S, Graubner S, Demuth HU Glutaminyl Cyclase Knock-out Mice Exhibit Slight Hypothyroidism but No Hypogonadism: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT. J Biol Chem 2011; 286(16): 14199-14208
Schliebs R, Arendt T The cholinergic system in aging and neuronal degeneration. Behav Brain Res 2011; 221: 555-563
Schulz I, Engel C, Niestroj AJ, Zeitschel U, Menge K, Kehlen A, Meyer A, Rossner S, Demuth HU Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-kappaB signaling pathway. J Neuroinflammation 2011; 8(1): 86
Sikora E, Arendt T, Bennett M, Narita M Impact of cellular senescence signature on ageing research. Ageing Res Rev 2011; 10(1): 146-152
Stieler JT, Bullmann T, Kohl F, Toien O, Brückner MK, Härtig W, Barnes BM, Arendt T The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation. PLoS One 2011; 6(1): 1-19
Tedde A, Piaceri I, Bagnoli S, Lucenteforte E, Ueberham U, Arendt T, Sorbi S, Nacmias B Association Study of Genetic Variants in CDKN2A/CDKN2B Genes/Loci with Late-Onset Alzheimer\'s Disease. Int J Alzheimers Dis 2011; 2011: 374631
Wilhelm F, Winkler U, Morawski M, Jäger C, Reinecke L, Rossner MJ, Hirrlinger PG, Hirrlinger J The human ubiquitin C promoter drives selective expression in principal neurons in the brain of a transgenic mouse line. Neurochem Int 2011; 59(6): 976-980

2010

Alpár A, Künzle H, Gärtner U, Popkova Y, Bauer U, Grosche J, Reichenbach A, Härtig W Slow age-dependent decline of doublecortin expression and BrdU labeling in the forebrain from lesser hedgehog tenrecs. Brain Res 2010; 1330: 9-19
Arendt T, Brückner MK, Mosch B, Lösche A Selective cell death of hyperploid neurons in Alzheimer\'s disease. Am J Pathol 2010; 177(1): 15-20
Arendt T, Ueberham U Novel developments in molecular and gene therapy of Alzheimer\'s disease: targeting the cell cycle. In: Ortuño Sahagún D, Beas Zarate C, Armendáriz J, Pallad Lliberia M, Camins A: Tópicos de Actuación en Neurobilogía: Biología molecular del desarollo, neurodegeneración y medicina genómica Universidad de Guadalajara, Guadalajara (2010); 267-287
Bullmann T, Härtig W, Holzer M, Arendt T Expression of the embryonal isoform (0N/3R) of the microtubule-associated protein tau in the adult rat central nervous system. J Comp Neurol 2010; 518(13): 2538-2553
Gáti G, Morawski M, Lendvai D, Jäger C, Négyessy L, Arendt T, Alpár A Distribution and classification of aggrecan-based extracellular matrix in the thalamus of the rat. J Neurosci Res 2010; 88(15): 3257-3266
Gáti G, Morawski M, Lendvai D, Matthews RT, Jäger C, Zachar G, Arendt T, Alpár A Chondroitin sulphate proteoglycan-based perineuronal net establishment is largely activity-independent in chick visual system. J Chem Neuroanat 2010; 40(3): 243-247
Heun R, Gühne U, Luck T, Angermeyer MC, Ueberham U, Potluri R, Natalwala A, Arendt T, Riedel-Heller SG Apolipoprotein E allele 4 is not a sufficient or a necessary predictor of the development of Mild Cognitive Impairment. Eur Psychiatry 2010; 25(1): 15-18
Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Rossner S, Lichtenthaler SF ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J 2010; 29(17): 3020-3032
Lange M, Arendt T, Härtig W An inexpensive technique for dot blotting in a 96-well format. Anal Biochem 2010; 398(1): 129-131
Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, Lichtenthaler SF Bepridil and amiodarone simultaneously target the Alzheimer\'s disease beta- and gamma-secretase via distinct mechanisms. J Neurosci 2010; 30(26): 8974-8983
Morawski M, Brückner G, Jäger C, Seeger G, Arendt T Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease. Neuroscience 2010; 169(3): 1347-1363
Morawski M, Brückner G, Jäger C, Seeger G, Künzle H, Arendt T Aggrecan-based extracellular matrix shows unique cortical features and conserved subcortical principles of mammalian brain organization in the Madagascan lesser hedgehog tenrec (Echinops telfairi Martin, 1838). Neuroscience 2010; 165(3): 831-849
Morawski M, Hartlage-Rübsamen M, Jäger C, Waniek A, Schilling S, Schwab C, McGeer PL, Arendt T, Demuth HU, Rossner S Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer\'s disease. Acta Neuropathol 2010; 120(2): 195-207
Morawski M, Pavlica S, Seeger G, Grosche J, Kouznetsova E, Schliebs R, Brückner G, Arendt T Perineuronal nets are largely unaffected in Alzheimer model Tg2576 mice. Neurobiol Aging 2010; 31(7): 1254-1256
Naumann N, Alpar A, Ueberham U, Arendt T, Gärtner U Transgenic expression of human wild-type amyloid precursor protein decreases neurogenesis in the adult hippocampus. Hippocampus 2010; 20(8): 971-979
Rogowski K, van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND, Lacroix B, Grau MB, Bec N, Larroque C, Desagher S, Holzer M, Andrieux A, Moutin MJ, Janke C A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell 2010; 143(4): 564-578
Rogowski K, van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND, Lacroix B, Grau MB, Bec N, Larroque C, Desagher S, Holzer M, Andrieux A, Moutin MJ, Janke C A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell 2010; 143(4): 564-578
Ueberham E, Bottger J, Ueberham U, Grosche J, Gebhardt R Response of sinusoidal mouse liver cells to choline-deficient ethionine-supplemented diet. Comp Hepatol 2010; 9: 8

2009

Alpar A, Naumann N, Arendt T, Gärtner U Constitutively enhanced p21Ras activity amplifies dendritic remodeling of hippocampal neurons during physical activity. Int J Dev Neurosci 2009; 27(4): 407-411
Alpar A, Naumann N, Ueberham U, Arendt T, Gärtner U Deprivation-induced dendritic shrinkage might be oppositely affected by the expression of wild-type and mutated human amyloid precursor protein. J Neurosci Res 2009; 87(8): 1813-1822
Arendt T Synaptic degeneration in Alzheimer\'s disease. Acta Neuropathol 2009; 118(1): 167-179
Arendt T, Mosch B, Morawski M Neuronal Aneuploidy in Health and Disease: A Cytomic Approach to Understand the Molecular Individuality of Neurons. Int J Mol Sci 2009; 10(4): 1609-1627
Bullmann T, Holzer M, Mori H, Arendt T Pattern of tau isoforms expression during development in vivo. Int J Dev Neurosci 2009; 27(6): 591-597
Enard W, Gehre S, Hammerschmidt K, Holter SM, Blass T, Somel M, Bruckner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Muller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Mossbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, de Angelis MH, Fischer J, Schwarz J, Pääbo S. A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 2009; 137(5): 961-971
Franze K, Gerdelmann J, Weick M, Betz T, Pawlizak S, Lakadamyali M, Bayer J, Rillich K, Gogler M, Lu YB, Reichenbach A, Janmey P, Käs J Neurite branch retraction is caused by a threshold-dependent mechanical impact. Biophys J 2009; 97(7): 1883-1890
Hoffmeister A, Dietz G, Zeitschel U, Mossner J, Rossner S, Stahl T BACE1 is a newly discovered protein secreted by the pancreas which cleaves enteropeptidase in vitro. JOP 2009; 10(5): 501-506
Morawski M, Alpár A, Brückner G, Fiedler A, Jäger C, Gati G, Stieler JT, Arendt T Chondroitin sulfate proteoglycan-based extracellular matrix in chicken (Gallus domesticus) brain. Brain Res 2009; 1275: 10-23
Schmetsdorf S, Arnold E, Holzer M, Arendt T, Gärtner U A putative role for cell cycle-related proteins in microtubule-based neuroplasticity. Eur J Neurosci 2009; 29(6): 1096-1107
Schulze C, Muller K, Käs JA, Gerdelmann JC Compaction of cell shape occurs before decrease of elasticity in CHO-K1 cells treated with actin cytoskeleton disrupting drug cytochalasin D. Cell Motil Cytoskeleton 2009; 66(4): 193-201
Seeger G, Gartner U, Ueberham U, Rohn S, Arendt T FAD-mutation of APP is associated with a loss of its synaptotrophic activity. Neurobiol Dis 2009; 35(2): 258-263
Stieler JT, Bullmann T, Kohl F, Barnes BM, Arendt T PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation. J Neural Transm 2009; 116(3): 345-350
Ueberham U, Lange P, Ueberham E, Bruckner MK, Hartlage-Rubsamen M, Pannicke T, Rohn S, Cross M, Arendt T Smad2 isoforms are differentially expressed during mouse brain development and aging. Int J Dev Neurosci 2009; 27(5): 501-510

2008

Alpár A, Naumann N, Härtig W, Arendt T, Gärtner U Enhanced Ras activity preserves dendritic size and extension as well as synaptic contacts of neurons after functional deprivation in synRas mice. Eur J. Neurosci 2008; 27: 3083-3094
Arendt T Differentiation and De-Differentiation - Neuronal Cell-Cycle Regulation During Development and Age-Related Neurodegenerative Disorders In: Lajtha A, Perez-Polo JR, Roßner S: Handbook of Neurochemistry and Molecular Neurobiology Development and Aging Changes in the Nervous System Springer Verlag, New York (2008); 157-214 ISBN 978-0.387-32670-2
Berbaum K, Shanmugam K, Stuchbury G, Wiede F, Korner H, Munch G Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array. Cytokine 2008; 41(3): 198-203
Bigl K, Gaunitz F, Schmitt A, Rothemund S, Schliebs R, Munch G, Arendt T Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation. J Neural Transm 2008; 115(11): 1545-1556
Brückner G1, Morawski M1, Arendt T (1These authors contributed equally to this work.) Aggrecan-Based Extracellular Matrix is an Integral Part of the Human Basal Ganglia Circuit. Neurosci 2008; 151: 489-504
Buggia-Prevot V, Sevalle J, Rossner S, Checler F NF{kappa}B-dependent Control of BACE1 Promoter Transactivation by A{beta}42. J Biol Chem 2008; 283(15): 10037-10047
Bullmann T, Stevenson PA Nitric Oxide as an Efferent Modulator of Circadian Pacemaker Neurones in the Eye of the Marine Mollusc Bulla gouldiana The Open Zoology Journal 2008; 1: 18-28
Bullmann T, Stieler J, Holzer M, Härtig W, Arendt T Hibernation, famine et hypothermie - Modèles pour la maladie d'Alzheimer (Hibernation, Starvation and Hypothermia Models for Alzheimer's Disease. Alzheimer Actualités 2008; 1996: 8-12
Delobel P, Lavinir I, Fraser G, Ingram E, Holzer M, Ghetti B, Spillantini MG, Growther RA Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy. Am J Pathol. 2008; 172(1): 123-131
Lohr M, Tzouras G, Molcanyi M, Ernestus RI, Hampl JA, Fischer JH, Sahin K, Arendt T, Hartig W Degeneration of cholinergic rat Basal forebrain neurons after experimental subarachnoid hemorrhage. Neurosurgery 2008; 63(2): 336-344
Riedel A, Westerholz S, Braun K, Edwards RH, Arendt T, Härtig W Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum J Chem Neuroanat 2008; 36: 177-190
Roßner S, Lichtenthaler SF Alzheimer's Disease BACE Proteases In: Lajtha A, Perez-Polo JR, Rossner S: Handbook of Neurochemistry and Molecular Neurobiology Development and Aging Changes in the Nervous System Springer, New York (2008); 261-284 ISBN 978-0-387-32670-2
Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth H, Rossner S Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer\'s disease-like pathology. Nat Med 2008; 14(10): 1106-1111
Schneider HJ, Rossner S, Pfeiffer D, Hagendorff A D-ribose improves cardiac contractility and hemodynamics, and reduces expression of c-fos in the hippocampus during sustained slow ventricular tachycardia in rats Int J Cardiol 2008; 125: 49-56
Shanmugam K, Holmquist L, Steele M, Stuchbury G, Berbaum K, Schulz O, Benavente Garcia O, Castillo J, Burnell J, Garcia Rivas V, Dobson G, Munch G Plant-derived polyphenols attenuate lipopolysaccharide-induced nitric oxide and tumour necrosis factor production in murine microglia and macrophages. Mol Nutr Food Res 2008; 52(4): 427-438
Ueberham E, Lindner R, Kamprad M, Hiemann R, Hilger N, Woithe B, Mahn D, Cross M, Sack U, Gebhardt R, Arendt T, Ueberham U Oval cell proliferation in p16INK4a expressing mouse liver is triggered by chronic growth stimuli. J Cell Mol Med 2008; 12(2): 622-638

2007
Alpar A, Ueberham U, Seeger G, Arendt T, Gartner U Effects of wild-type and mutant human amyloid precursor protein on cortical afferent network. Neuroreport 2007; 18(12): 1247-1250
Arendt T, Bruckner MK Linking cell-cycle dysfunction in Alzheimer\'s disease to a failure of synaptic plasticity. Biochim Biophys Acta 2007; 1772(4): 413-421
Bigl K, Schmitt A, Meiners I, Münch G, Arendt T Comparison of results of th CellTiter Blue, the tetrazolium (3-[4,5-dimethylthioazol-2-yl]-2,5-diphenyl tetrazolium bromide), and the lactate dehydrogenase assay applied in brain cells after exposure to advanced glycation endproducts Tox in Vitro 2007; 21: 962-971
Bourne KZ, Ferrari DC, Lange-Dohna C, Rossner S, Wood TG, Perez-Polo JR Differential Regulation of BACE1 Promoter Activity by Nuclear Factor-kB in Neurons and Glia Upon Exposure to ß-Amyloid Peptides J Neurosci Res 2007; 85: 1194-1204
Bullmann T, de Silva R, Holzer M, Mori H, Arendt T Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus. Hippocampus 2007; 17(2): 98-102
Dityatev A, Brückner G, Dityateva G, Grosche J, Kleene R, Schachner M Activity-dependent formation and functions of chondroitin sulfate-rich extracellular matrix of perineuronal nets. Develop Neurobiol 2007; 67(5): 570-588
Fiedler A, Reinert T, Morawski M, Bruckner G, Arendt T, Butz T Intracellular iron concentration of neurons with and without perineuronal nets NIMB 2007; 260: 153-158
Hartig W, Stieler J, Boerema AS, Wolf J, Schmidt U, Weissfuss J, Bullmann T, Strijkstra AM, Arendt THibernation model of tau phosphorylation in hamsters: selective vulnerability of cholinergic basal forebrain neurons - implications for Alzheimer's disease. Eur J Neurosci 2007; 25(1): 69-80
Ihunwo AO, Luth HJ, Schliebs R, Kayanja FIB Ultrastructural Features of Beta-Amyloid Plaques in Aged Transgenic Tg2576 Mouse Brain with Alzheimer Plaque Pathology Res J Med Sci 2007; 1(2): 55-61
Kuhla B, Boeck K, Schmidt A, Ogunlade V, Arendt T, Munch G, Luth HJ Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains. Neurobiol Aging 2007; 28(1): 29-41
Kuhla B, Haase C, Flach K, Luth HJ, Arendt T, Munch GEffect of Pseudophosphorylation and Cross-linking by Lipid Peroxidation and Advanced Glycation End Product Precursors on Tau Aggregation and Filament Formation. J Biol Chem 2007; 282(10): 6984-6991
Milius D, Groger-Arndt H, Stanchev D, Lange-Dohna C, Rossner S, Sperlagh B, Wirkner K, Illes P Oxygen/glucose deprivation increases the integration of recombinant P2X(7) receptors into the plasma membrane of HEK293 cells. Toxicology 2007; 238(1): 60-69
Mosch B, Morawski M, Mittag A, Lenz D, Tarnok A, Arendt T Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease. J Neurosci 2007; 27(26): 6859-6867
Reimers S, Hartlage-Rübsamen M, Brückner G, Rossner S Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity Eur J Neurosci 2007; 25: 2640-2648
Reinert T, Fiedler A, Morawski M, Arendt T High resolution quantitative element mapping of neuromelanin-containing neurons NIMB 2007; 260: 227-230
Schmetsdorf S, Gartner U, Arendt TConstitutive expression of functionally active cyclin-dependent kinases and their binding partners suggests noncanonical functions of cell cycle regulators in differentiated neurons. Cereb Cortex 2007; 17(8): 1821-1829
Schmidt A, Kuhla B, Bigl K, Munch G, Arendt T Cell cycle related signaling in neuro2a cells proceeds via the receptor for advanced glycation end products. J Neural Transm 2007; 114(11): 1413-1424
Ueberham E, Aigner T, Ueberham U, Gebhardt R E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells. J Mol Histol 2007; 38(4): 359-368
Weng HL, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H, Kanzler S, Heuchel R, Ueberham U, Gebhardt R, Breitkopf K, Dooley SProfibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes. Hepatology 2007; 46(4): 1257-1270

2006
Alpar A, Gartner U, Hartig W, Bruckner G Distribution of pyramidal cells associated with perineuronal nets in the neocortex of rat. Brain Res 2006; 1120(1): 13-22
Alpar A, Ueberham U, Bruckner MK, Arendt T, Gartner UThe expression of wild-type human amyloid precursor protein affects the dendritic phenotype of neocortical pyramidal neurons in transgenic mice. Int J Dev Neurosci 2006; 24: 133-140
Alpar A, Ueberham U, Bruckner MK, Seeger G, Arendt T, Gartner UDifferent dendrite and dendritic spine alterations in basal and apical arbors in mutant human amyloid precursor protein transgenic mice. Brain Res 2006; 1099(1): 189-198
Bruckner G, Pavlica S, Morawski M, Palacios AG, Reichenbach A Organization of brain extracellular matrix in the Chilean fat-tailed mouse opossum Thylamys elegans (Waterhouse, 1839). J Chem Neuroanat 2006; 32: 143-158
Delobel P, Lavenir I, Ghetti B, Holzer M, Goedert M Cell-Cycle Markers in a Transgenic Mouse Model of Human Tauopathy; Increased Levels of Cyclin-Dependent Kinase Inhibitors p21Cip1 and p27Kip1. Am J Pathol 2006; 168(3): 878-887
Gärtner U, Arendt T Animal Models of Alzheimer's Disease. In: Koch M: Animal Models of Neuropsychiatric Diseases. Imperial College Press, London (2006); 1-74. ISBN 1-86094-618-6
Gericke CA, Schulte-Herbruggen O, Arendt T, Hellweg R Chronic alcohol intoxication in rats leads to a strong but transient increase in NGF levels in distinct brain regions. J Neural Transm 2006; 113(7): 813-820
Hartig W, Lehmann J, Stieler J, Singer D, Grosche J, Arendt T, Hoffmann R Simultaneous detection of tau phospho-epitopes with haptenylated antibodies. Neuroreport 2006; 17(9): 869-874
Hoozemans JJ, Stieler J, van Haastert ES, Veerhuis R, Rozemuller AJ, Baas F, Eikelenboom P, Arendt T, Scheper W The unfolded protein response affects neuronal cell cycle protein expression: Implications for Alzheimer's disease pathogenesis. Exp Gerontol 2006; 41(4): 380-386
Kuhla B, Boeck K, Luth HJ, Schmidt A, Weigle B, Schmitz M, Ogunlade V, Munch G, Arendt T Age-dependent changes of glyoxalase I expression in human brain. Neurobiol Aging 2006; 27(6): 815-822
Kuhla B, Luth HJ, Haferburg D, Weick M, Reichenbach A, Arendt T, Munch G Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells. J Neurosci Res 2006; 83(8): 1591-1600
Langer KA, Poon HF, Munch G, Lynn CB, Arendt T, Butterfield DA Identification of AGE-modified proteins in SH-SY5Y and OLN-93 cells. Neurotox Res 2006; 9(4): 255-268
Meinecke C, Morawski M, Reinert T, Arendt T, Butz T Cellular distribution and localisation of iron in adult rat brain (substantia nigra) NIMB 2006; 249: 688-691
Mosch B, Mittag A, Lenz D, Arendt T, Tárnok A Laser Scanning Cytometry in Human Brain Slices. Cytometry Part A 2006; 69A: 135-138
Reinert T, Spemann D, Morawski M, Arendt T Quantitative trace element analysis with sub-micron lateral resolution NIMB 2006; 249: 734-737
Schliebs R, Arendt T The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. J Neural Transm 2006; 113(11): 1625-1644
Schmitt A, Bigl K, Meiners I, Schmitt JInduction of reactive oxygen species and cell survival in the presence of advanced glycation end products and similar structures. Biochim Biophys Acta 2006; 1763(9): 927-936
Ueberham U, Ueberham E, Gruschka H, Arendt T Altered subcellular location of phosphorylated Smads in Alzheimer's disease. Eur J Neurosci 2006; 24(8): 2327-2334
Ueberham U, Zobiak B, Ueberham E, Bruckner MK, Boriss H, Arendt T Differentially expressed cortical genes contribute to perivascular deposition in transgenic mice with inducible neuron-specific expression of TGF-beta1. Int J Dev Neurosci 2006; 24: 177-186

2005
Arendt E, Ueberham U, Bittner R, Gebhardt R, Ueberham E Enhanced matrix degradation after withdrawal of TGF-beta1 triggers hepatocytes from apoptosis to proliferation and regeneration. Cell Prolif 2005; 38(5): 287-299
Arendt T Alzheimer's disease as a disorder of dynamic brain self-rganization. Prog Brain Res 2005; 147: 355-378
In: van Pelt J et al. (eds.) Development, Dynamics and Pathology of Neuronal Networks from Molecules to Functional Circuits. Proceedings of the 23rd Int. Summer School of Brain Res., held at the Royal Netherlands Academy of Arts and Sciences Amsterdam, 25-29 August 2003. Elsevier, Amsterdam 2005: 355-378 ISBN 0-444-51663-8.
Arendt T Cell Cycle Activation in Neurons: The Final Exit of Brain-Morpho-Dysregulation In: Copani A, Nicoletti F: Cell-Cycle Mechanisms and Neuronal Cell Death Landes Bioscience and Kluwer Academic, Georgetown (2005); 1-21 ISBN 0-306-47850-1
Briel D, Drossler K, Rybak A, Holzer M, Dobner B Protected mercaptoalkylpyrimidinones: synthesis and test for immunostimulating activity. Pharmazie 2005; 60(6): 415-417
Butz T, Meinecke C, Morawski M, Reinert T, Schwertner M, Spemann D, Vogt J Morphological and elemental characterisation with the high-energy ion-nanoprobe LIPSION. Appl Surf Sci 2005; 252: 43-48
Da Fontoura Costa L, Soares Barbosa M, Schierwagen A, Alpár, A, Gärtner U, Arendt T Active Percolation analysis of Pyramidal Neurons of Somatosensory Cortex: A Comparison of Wild Type and p21H-RasVal12 Transgenic Mice Int J Mod Physics C 2005; 16(4): 655-667
Franz H, Ullmann C, Becker A, Ryan M, Bahn S, Arendt T, Simon M, Pääbo S, Khaitovich P Systematic analysis of gene expression in human brains before and after death. Genome Biology 2005; 6: 112-120
Gärtner U, Alpár A, Behrbohm J, Heimann R, Arendt T Enhanced Ras activity promotes spine formation in synRas mice neocortex. NeuroReport 2005; 16(2): 149-152
Härtig W, Oklejewicz M, Strijkstra AM, Boerema AS, Stieler J, Arendt T Phosphorylation of the tau protein sequence 199-205 in the hippocampal CA3 region of Syrian hamsters in adulthood and during aging. Brain Res 2005; 1056: 100-104
Hensel A, Wolf H, Busse A, Arent T, Gertz HJ Association between global brain volume and the rate of cognitive change in elderly humans without dementia. Dement Geriatr Cogn Disord 2005; 19(4): 213-221
Hensel A, Wolf H, Dieterlen T, Riedel-Heller S, Arendt T, Gertz HJ Morphometry of the amygdala in patients with questionable dementia and mild dementia. J Neurol Sci 2005; 238: 71-74
Heumann R, Mittmann T, Arendt T Wie das Gehirn auf Zuwachs schaltet. Rubin 2005; 1: 49-54
Hoozemans JJ, van Haastert ES, Veerhuis R, Arendt T, Scheper W, Eikelenboom P, Rozemuller AJ Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease. J Neuroinflammation 2005; 2(1): 27-
Kuhla B, Lüth HJ, Haferburg D, Boeck K, Arendt T, Münch G Methylglyoxal, glyoxal, and their detoxification in Alzheimer's disease. Ann N Y Acad Sci 2005; 1043: 211-216
Lenz D, Mittag A, Mosch B, Bocsi J, Arendt T, Tarnok A Tissomics: two- and threedimensional distribution of nuclei in brain tissue using Laser Scanning Cytoemtry (LSC). Proceedings of SPIE 2005; 5701: 101-111
Lüth HJ, Ogunlade V, Kuhla B, Kientsch-Engel R, Stahl P, Webster J, Arendt T, Münch GAge-and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains. Cereb Cortex 2005; 15(2): 211-220
Miettinen R, Riedel A, Kalesnykas G, Kettunen HP, Puolivali J, Soininen H, Arendt T Reelin-immunoreactivity in the hippocampal formation of 9-month-old wildtype mouse: effects of APP/PS1 genotype and ovariectomy. J Chem Neuroanat 2005; 30: 105-118
Morawski M, Meinecke C, Reinert T, Dörffel AC, Riederer P, Arendt T, Butz T Determination of trace elements in the human substantia nigra. NIM B 2005; 231: 224-228
Morawski M, Reinert T, Meinecke C, Arendt T, Butz T Antibody meets the microbeam - or how to find neurofibrillary tangles. NIM B 2005; 231: 229-233
Morawski M, Arendt T, Reinert T, Butz T Spurensuche im Gehirn - Ortsaufgelöste Elementaranalyse von zellulären und subzellulären Strukturen im Gehirn mit der Leipziger Ionen-Nanosonde "Lipsion". BIOforum 2005; 6: 17-19
Richter T, Münch G, Lüth HJ, Arendt T, Kientsch-Engel R, Stahl P, Fengler D, Kuhla BImmunochemical crossreactivity of antibodies specific for "advanced glycation endproducts" with "advanced lipoxidation endproducts". Neurobiology of Aging 2005; 26(6): 465-474
Schmetsdorf S, Gärtner U, Arendt T Expression of cell cycle-related proteins in developing and adult mouse hippocampus. Int J Dev Neurosci 2005; 23(1): 101-112
Seeger G, Gärtner U, Arendt T Transgenic activation of Ras in neurons increases synapse formation in mouse neocortex. J Neural Transmission 2005; 112(6): 751-761
Ueberham U, Arendt T The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease. Curr Drug Targets CNS Neurol Disord 2005; 4(4): 293-306
Ueberham U, Ueberham E, Brückner MK, Seeger G, Gärtner U, Gruschka H, Gebhardt R, Arendt T Inducible neuronal expression of transgenic TGF-ß1 in vivo: dissection of short-term and long-term effects. Eur J Neurosci 2005; 22: 50-64
Webster J, Urban C, Berbaum K, Loske C, Alpar A, Gärtner U, Garcia de Arriba S, Arendt T, Münch G The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal. Neurotox Res 2005; 7(1-2): 95-101
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2004
Allgaier C, Arendt T Gelantamine, an acetylcholinesterase inhibitor with various actions. Med Monatsschr Pharm 2004; 27(7): 223-227
Alpár A, Seeger G, Härtig W, Arendt T, Gärtner UAdaptive morphological changes of neocortical interneurons in response to enlarged and more complex pyramidal cells in p21H-Ras Val12 transgenic mice. Brain Res Bull 2004; 62(4): 335-343
Alpár A, Gärtner U, Weeger G, Härtig W, Brauer K, Arendt T Constitutive Expression of p21H-ras Val12 in Pyramidal Neurons Results in Reorganization of Mouse Neocortical Afferents. J Neurobiol 2004; 60(3): 263,274
Arendt T, Gärtner U, Seeger G, Barmashenko G, Palm K, Mittmann T, Yan L, Hümmecke M, Behrbohm J, Brückner MK, Holzer M, Wahle P, Heumann R Neuronal activation of Ras regulates synaptic connectivity. Eur. J. Neuroscie 2004; 19: 2953-2966
Arent T, Stieler J, Strijkstra AM, Hut RA, Van der Zee EA, Holzer M, Härtig W Hibernation in Mammals: A Model for Alzheimer-type Phosphorylation of the Microtubule-associated Protein Tau. Life in the Cold Evolution, Mechanisms, Adaptation and Application. Twelfth International Hibernation Symposium July 25-August 2 2004. 2004; 27: 497-507
Arendt Th Neurodegeneration and plasticity. Int,J.Devl. Neuroscience 2004; 22: 507-514
Arent Th Aktivierung entwicklungsneurobiologischer Mechanismen im Prozess der Neurodegeneration. In: Bernert G: Aktuelle Neuropädiatrie 2003. Novartis Pharma Verlag, Nürnberg (2004); 59-67 ISBN 3-933185-62-9
Bernstein HG, Brisch R, Ogunlade V, Heinemann A, Baumann B, Arendt T, Dobrowolny H, Bogerts B, Lüth HJ Detection of nitric oxide synthase (NOS) immunoreacitive neurons in the human septal area: a matter of method? J Chem Neuroanat 2004; 27: 247-250
Eichler W, Stieler JT, Vogel B, Wobus M, Aust G Molecular cloning of bovine CD97: an EGF-TM7 molecule expressed as isoforms. Mol Immunol 2004; 41(8): 751-758
Fonck C, Nashmi R, Deshpande P, Damaj MI, Marks MJ, Riedel A, Schwarz J, Collins AC, Labarca C, Lester HAIncreases sensitivity to agonist-induced seizures, straub tail, hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nicotinic receptors. Int J Devl Neurosci 2004; 22; 571-599
Gärtner U, Alpár A, Seeger G, Heumann R, Arendt T.Enhanced Ras activity in pyramidal neurons induces cellular hypertrophy and changes in afferent and intrinsic connectivity in synRas mice. J Devl Neurosci 2004; 22(3): 165-173
Gärtner U, Alpár A, Reimann F, Seeger G, Heumann R, Arent T Constitutive Ras Activity Induces Hippocampal Hypertrophy and Remodeling of Pyramidal Neurons in synRas Mice. J Neurosci Res 2004; 77: 630-641
Haase C, Stieler J, Arendt T, Holzer M Pseudophosphorylation of tau protein alters its ability for self-aggregation. J Neurochem 2004; 88(6): 1509-1520
Holzer M, Craxton M, Jakes R, Arendt T, Goedert M Tau gene (MAPT) sequence variation among primates. Gene 2004; 341: 313-322
Hoozemans JJM, Veerhuis R, Rozemuller AJM, Arendt T, Eikelenboom PNeuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex. Neurobiology of disease 2004; 15: 492-499
Khaitovich P, Muetzel B, She X, Lachmann M, Hellman I, Diezsch J, Steigele S, Do HH, Weiss G, Enard W, Heissig F, Arendt T, Nieselt-Struwe K, Eichler EE, Pääbo S Regional Patterns of Gene Expression in Human and Chimpanzee Brains. Genome Res 2004; 14(8): 1462-1473
Knupfer H, Schmidt R, Stanitz D, Brauckhoff M, Schönfelder M, Preiss R DYP2C and IL-6 expression in breast cancer. Breast 2004; 13(1): 28-34
Lenz D., Mosch B, Bosci J, Arendt T, Tarnok A Assessment of DNA replication in central nervous system by Laser Scanning Cytometry. Proc SPIE 2004; 5322: 146-156
Morawski M, Brückner MK, Riederer P, Brückner G, Arendt T. Perineuronal nets potentially protect against oxidative stress. Exp Neurol 2004; 188: 309-315
Morawski M, Reinert T, Brückner G, Wagner FE, Arendt T, Tröger W The Binding of Iron to Perineuronal Nets: A Combined Nuclear Microscopy and Mössbauer Study. Hyperfine Interactions 2004; 159: 285-291
Seeger G, Yan L, Gärtner U, Huemmeke M, Barmashenko G, Mittmann T, Heumann R, Arendt T Activation of Ras in neurons modifies synaptic vesicle docking and release. NeuroReport 2004; 15(17): 2651-2654
Schmidt R, Baumann F, Knupfer H, Brauckhoff M, Horn LC, Schönfelder M, Kohler U, Preiss R CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes. Br J Cancer 2004; 90(4): 911-916
Wolf H, Hensel A, Arendt T, Kivipelto M, Winblad B Serum Lipids and Hippocampal Volume: The Link to Alzheimer´s Disease? Ann Neurol 2004; 56(5): 745-756
Wolf H, Hensel A, Kruggel F, Riedel-Heller S, Arendt T, Wahlund LO, Gertz HJ Structural correlates of mild cognitive impairment. Neurobiology Aging 2004; 25(7): 913-924
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2003
Alpár A, Palm K, Schierwagen A, Arendt T, Gärtner U Expression of constitutively active p21H-rasVa112 in postmitotic pyramidal neurons results in increased dendritic size and complexity. J Comp Neurol 2003; 467: 119-133
Arendt TSynaptic plasticity and cell cycle activation in neurons are alternateve effector pathways: The Dr. Jekyll and Mr. Hyde Theory of Alzheimer’s disease or The yin and yang of Neuroplasticity. Progr Neurobiol 2003; 71: 83-248
Arendt T, Stieler J, Strijkstra AM, Hut RA, Rüdiger J, Van der Zee E, Harkany T, Holzer M, Härtig W Reversible PHF-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals. J Neuroscience 2003; 23(18): 6972-6981
Gärtner U, Brückner MK, Krug S, Schmetsdorf S, Staufenfeld M Arendt T Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons. Acta Neuropathol 2003; 106: 535-544
Härtig W, Riedel A, Grosche J, Edwards RH, Harkany T, Brauer K, Arendt TComplementary distribution of vesicular glutamate transporters 1 and 2 in the nucleus accumbens of rat: Relationship to calretinin-containing extrinsic innervation. J Comp Neurol 2003; 465: 1-10
Lüth HJ, Apelt J, Ihunwo AO, Arendt T, Schliebs R Degeneration of ß-amyloid-associated cholinergic structures in transgenic APPSW mice. Brain Res 2003; 977: 16-22.
Münch G, Kuhla B, Lüth HJ, Arendt T, Robinson SR Anti-AGEing defences against Alzheimer’s disease. Biochem Soc Transactions 2003; 31: 1397-1399
Münch G, Gasic-Milenkovic G, Arendt T Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer´disease J Neural Tansm Suppl 2003; 65:63-71
Reinert T, Morawski M, Arendt T, Butz T Quantitative Microanalysis of Perineuronal Nets in Brain Tissue. NIM in Physics Research B 2003; 210: 395-400
Riedel A, Miettinen R, Stieler J, Mikkonen M, Alafuzoff I, Soininen H, Arendt T Reelin-immunoreactive Cajal-Retzius cells: The entorhinal cortex in normal aging and Alzheimer’s disease. Acta Neuropathol 2003; 106: 9291-302
Seeger G, Gärtner U Holzer M, Arendt T Constitutive Expression of p21H-RasVal12 in Neurons Induces Increased Axonal Size and Dendritic Microtubule Density in vivo. J Neurosci Res 2003; 74: 868-87
Wolf H, Kruggel F, Hensel A, Wahlund LO, Arendt T The relationship between head size and intracranial volume in elderly subjects. Brain Res 2003; 973: 74-80
Ueberham U, Hessel A, Arendt T Cyclin C expression is involved in the pathogenesis of Alzheimer’s disease. Neurobiol of Aging 2003; 24: 427-435.
Ueberham U, Ueberham E, Gruschka H, Arendt T Connective tissue growth factor in Alzheimer’s Disease. Neurosci 2003; 116: 1-6.
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2002
Arendt, T Dysregulation of neuronal differentiation and cell cycle control in Alzheimer’s disease. J Neural Transm 62 (2002) 77 – 85.
Gärtner, U., Härtig, W., Riedel, A., Brauer, K., Arendt, TH. Immunocytochemical evidence for the striatal nature of the rat lateral part of interstitial nucleus of the posterior limb of the anterior commissure (IPAC). Journal of Chemical Neuroanatomy 24 (2002) 117 – 125
Herrup, K., Arendt, Th. Re-expression of cell cycle proteins induces neuronal cell death during Alzheimer’s disease. Journal of Alzheimer’s Disease 4 (2002) 243-247
Holzer, M., Gärtner, U., Stöbe, A., Härtig, W., Gruschka, H., Brückner, M.K., Arendt, TH. Inverse association of Pin1 and tau accumulation in Alzheimer’s disease hippocampus. Acta Neuropathol 104 (2002) 471-481
Hoozemans, J.J., Brückner, M.K., Rozemuller, A.J.M., Veerhuis, R., Eikelenboom, Arendth, Cyclin D1 and Cyclin E Are Co-Localized with Cyclo-Oxygenase 2 (COX-2) in Pyramidal Neurons in Alzheimer Disease Temporal Cortex. J Neuropathol. Exp. Neurol. 61 (2002) 678 – 688
Kruggel F., Brückner M.K., Arendt Th., Wiggins C.J., von Cramon D.Y. Analyzing the neocortical fine-structure Information Processing in Medical Imaging 7(2002)251-264
Lüth, H.J., Münch, G., Arendt, Th. Aberrant expression of NOS isoforms in Alzheimer’s disease is structurally related to nitrotyrosine formation. Brain Research 953 (2002) 135 – 143.
Münch, G., Shepherd, C.E., McCann, H., Brooks, W.S., Kwok, J.B.J., Arendt, TH., Hallupp, M., Schofield, P.R., Martins, R.N., Halliday, G.M. Intraneuronal advanced glycation endproducts in presenilin-I Alzheimer’s disease. NeuroReport 13 (2002) 601-604.
Otth, C., Concha, I.I., Arendt, Th., Stieler, J., Schliebs, R., Gonzalez-Billault, C., Maccioni, R.B. AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.Journal Alzheim. Dis. 4 (2002) 417 – 430
Riedel, A., Härtig, W., Seeger, G., Gärtner, U., Brauer, K., Arendt, Th. Principles of rat subcortical forebrain organization: a study using histological techniques and multiple fluorescence labeling. J. Chem. Neuroanat. 23 (2002) 75-104
Wei, Q., Holzer, M., Brueckner, M. K., Liu, Y., Arendt, Th. Dephosphorylation of Tau Protein by Calcineurin Triturated into Neural Living Cells. Cellular and Molecular Neurobiology 22 (2002) 13 –24.
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2001
Arendt, Th. Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer´s disease. Int.J.Dev.Neurosci. 19 (2001) 231-245
Arendt, Th. Alzheimer’s disease as a disorder of mechanisms underlaying structural brain self-organiza­tion. Commentary. Neuroscience 102 (2001) 723-765.
Gärtner, U., Härtig, W., Brauer, K., Brückner, G. and Arendt, Th. Electron micro­scopic evidence for different myelination of rat septohippocampal fibres. NeuroReport 12 (2001) 17-20.
Gärtner, U., Härtig, W., Brauer, K., Brückner, G. and Arendt, Th. Immunofluores­cence and immunoelectron microscopic evidence for differences in myelination of GABAergic and cho­linergic septohippocampal fibres. Int.J.Dev.Neurosci. 19 (2001) 347-352
Härtig, W., Klein, C., Brauer, K., Schüppel, K. F., Arendt, Th., Bigl, V. and Brück­ner, G. Hyperphosphoryylated protein tau is restricted to neurons devoid of perineuronal nets in the cortex of aged bisons. Neurobiology of Aging 22 (2001) 25-33.
Holzer M, Gärtner U, Klinz FJ, Narz F, Heumann R and Arendt Th. Activation of mitogen activated protein kinase cascade (MAPK)-cascade and phosphorylation of cytoskeletal proteins after neuron-specific activation of p21ras. I. MAPK-cascade. Neuroscience 105 (2001) 1031-1040.
Holzer M, Rödel L, Seeger G, Gärtner U, Narz F, Janke C, Heumann R and Arendt, Th. Activation of mitogen activated protein kinase (MAPK)-cascade and phosphorylation of cytoskeletal proteins after neuron-specific activation of p21ras. II. Cytoskeletal proteins and dendritic morphology. Neuroscience 105 (2001) 1040-1054.
Lüth HJ, Holzer M, Gärtner U, Staufenbiel M and Arendt Th. Expression of endothe­lial and inducible NOS-isoforms in increased in Alzheimer´s disease, in APP23 transgenic mice and after experimental brain lesion in rat. Brain Research 913 (2001) 57-67.
Wolf H, M. Grunwald, F. Kruggel, S.G. Riedel-Heller, S. Angerhöfer, A. Hojjato­leslami, A. Hensel, T. Arendt, H.-J. Gertz. Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiology of Aging 22 (2001) 177–186.
Stieler, JT, Lederer, C., Brückner, M.K., Wolf, H., Gertz, H.-J, Holzer, M and Arendt, Th. Impairment of mitogenic activation of peripheral blood lymphocytes in Alzheimer´s disease. Neuroreport 12 (2001) 3969-3972
Adams, I., Brauer, K., Arélin, C., Härtig, W., Fine, A., Mäder, M, Arendt, T. and Brückner, G. Perineuronal nets in the rhesus monkey and human basal forebrain including basal ganglia. Neuroscience 108 (2001) 285-298.
Grunwald, M., Busse, F., Angerhöfer, S., Kruggel, F., Wolf, H., Riedel-Heller, S., Arendt, T., Gertz, H.J. Correlation between cortical theta activity and hippocampal body volume in health, mild cognitive impairment, and mild dementia. Journal of Clinical Neurophysiology18 (2001) 178-184.
Wong, A., Lüth, H.-J., Deuther-Conrad, W., Dukic-Stefanovic, S., Gasic-Milen-kovic, J., Arendt, Th. and Münch, G. Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer´s disease. Brain Res. 920 (2001) 32-40
Wolf, H., Grunewald, M, Kruggel, F., Riedel-Heller, S.G., Angerhöfer, S., Hojjatoleslami, A., Hensel, A., Arendt, Th., Gertz, H.-J. Hippocampal volume discriminates between normal cognition: questionable and mild dementia in the elderly. Neurobiology of Aging22(2001)177-186
Knüpfer, H. and Arendt, Th. NGF increases cellsurvival rates under serum deprived conditions. Anticancer Research 21 (2001) 2797-2802.
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2000
Arendt, Th. Alzheimer’s disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain. Neurobiology of Aging 21 (2000) 783-796.
Arendt, Th., Holzer, M., Stöbe, A., Gärtner, U., Lüth, H.-J., Brückner, M. K. and Ueberham, U. Activated mitogenic signalling induces a process of de-differentiation in Alzheimer’s disease that eventually results in cell death. Ann. N. Y. Acad. Sci. 920 (2000) 249-255.
Beck, M., Brückner, M. K., Holzer, M., Kaap, S., Pannicke, Th., Arendt, Th. And Bigl, V. Expression and processing of guinea pig amyloid precursor protein in primary cell culture. Neuroscience 95 (2000) 243-254.
Brauer, K., Härtig, W., Gärtner, U., Brückner, G. and Arendt, Th. Different myelina­tion of rat septohippocampal fibres as revealed by immunofluorescence double-labelling. Brain Research 878 (2000) 188-193.
Brauer, K., Häußer, M., Härtig, W. and Arendt, Th. The core-shell dichotomy of nucleus accumbens in the rhesus monkey as revealed by double-immunofluorescence and morphology of cho­linergic interneurons. Brain Research 858 (2000) 151-162.
Härtig, W., Klein, C., Brauer, K., Schüppel, K. F., Arendt, Th., Brückner, G. and Bigl, V. Abnormally phosphorylated protein tauin the cortex of aged individuals of various mammalian orders. Acta Neuropathologica 100 (2000) 305-312.
Heumann, R., Goemans, C., Bartsch, D., Lingenhöhl, K., Waldmeier, P. C., Hengerer, B., Allegrini, P. R., Schellander, K., Wagner, E. F., Arendt, Th., Kam­dem, R. H., Obst-Pernberg, K., Narz, F., Wahle, P. and Berns, H. Transgenic activation of ras in neurons promotes hypertrophy and protects from lesion-induced degeneration. Journal of Cell Bi­ology (2000) 151, 1537-1548
Holzer, M., Brückner, M. K., Beck, M., Bigl, V. and Arendt, Th. Modulation of APP processing and secretion by okadaic acid in primary guinea pig neurons. J. Neural. Transm. 107 (2000) 451-461.
Janke, C., Beck, M., Holzer, M., Bigl, V. and Arendt, Th. Analysis of the molecular heteroge­neity of the microtubule-associated protein tau by two-dimensional electrophoresis and RT-PCR. Brain Research Protocols 5 (2000) 231-242.
Lüth, H.-J., Holzer, M., Gertz, H.-J. and Arendt, Th. Aberrant expression of nNOS in pyrami­dal neurons in Alzheimer’s disease is highly co-localized with p21ras and p16INK4a. Brain Re­search 852 (2000) 45-55.
Münch, G., Lüth, H.-J., Wong, A., Arendt, Th., Hirsch, E., Ravid, R. and Riederer, P. Crosslinking of a-synuclein by advanced glycation endproducts - an early pathophysiological step in Lewy body formation? Journal of Chemical Neuroanatomy 20 (2000) 253-257.
Yun, S.-W., Gärtner, U., Arendt, Th. and Hoyer, S. Increase in vulnerability of middle-aged rat brain to lead by cerebral energy depletion. Brain Research Bulletin 52 (2000) 371-378.
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1999
Arendt, Th., Holzer, M., Gertz H-J., and Brückner, M. K. Cortical load of PHF-tau in Alzhei­mer´s disease is correlated to cholinergic dysfunction. J. Neural Transmission 106 (1999) 513-523.
Arendt, Th., Lehmann K, Seeger, G. and Gärtner, U. Synergistic effects of THA and lith­ium on cholinergic function after excitotoxic basal forebrain lesion in rat. Pharmacopsychiatry 32 (1999) 242-247.
Bigl, M., Brückner, M. K., Arendt, Th., Bigl, V. and Eschrich, K. Activities of key glyco­lytic enzymes in the brains of patients with Alzheimer’s disease. Journal of Neural Transmission 106 (1999) 499-511.
Brauer, K., Holzer, M., Brückner, G., Tremere, L., Rasmusson, D. D., Poethke, R., Arendt, Th. and Härtig, W. Two distinct populations of Cholinergic neurons in the septum of raccoon (procyon lotor): Evidence for a separate subset in the lateral septum. Journal of Compa­rative Neurology 412 (1999) 112-122.
Brückner, G., Hausen, D., Härtig, W., Drlicek, M., Arendt, Th. and Brauer, K. Cortical areas abundant in extracel­lular matrix chondroitin sulphate proteoglycans are less affected by cytoskeletal changes in Alzhei­mer´s disease. Neuroscience 92 (1999) 791-805.
Gärtner, U., Holzer, M. and Arendt, Th. Elevated expression of p21ras is an early event in Alzhei­mer’s disease and precedes neurofibrillary degeneration. Neuroscience 91 (1999) 1-5.
Gertz, H.-J., Wolf, H. and Arendt, Th. Psychiatric disorders of the frontal lobe. Current Opin­ion in Psychiatry 12 (1999) 321-324.
Holzer, M., Holzapfel, H.-P., Krohn, K., Gertz, H.-J. and Arendt, Th. Alterations in content and phosphorylation state of cytoskeletal proteins in the sciatic nerve during ageing and in Alz­heimer’s disease. Journal of Neural Transmission 106 (1999) 743-755.
Janke, C., Beck, M., Stahl, T., Holzer M., Brauer, K., Bigl, V. Arendt, Th. Phyloge­netic di­versity of the expression of the microtubule-associated protein tau: Implications for neurodegen­erative disorders. Mol. Brain Res. 68 (1999) 119-128.
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1998

Arendt, Th., Holzer, M., Brückner, M. K., Janke, C. and Gärtner, U. The use of oka­daic acid in vivo and the induction of molecular changes typical for Alzheimer’s disease. Neuroscience 85, (1998) 1337-1340.
Arendt, Th., Holzer, M., Fruth, R., Brückner, M. K. and Gärtner, U. Phosphorylation of tau, A?-formation and apoptosis after in vivo inhibition of PP-1 and PP-2A. Neurobiology of Aging 19 (1998) 3-13.
Arendt, Th., Holzer, M. and Gärtner, U. Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer’s diesease. J. Neural Transmission 105 (1998) 949-960.
Arendt, Th., Holzer, M., Gärtner, U. and Brückner, M. K. Aberrancies in signal transduc­tion and cell cycle related events in Alzheimer’s disease. J. Neural Transmission, Suppl. 54 (1998) 147-158.
Gärtner, U., Janke, C., Holzer, M., Vanmechelen, E. and Arendt, Th. Postmortem changes in the phosphorylation state of tau protein in rat brain. Neurobiology of Aging, 19 (1998) 535-543.
Gertz, H.-J., Xuereb, J., Huppert, F., Brayne, C., McGee, M. A., Paykel, E., Harring­ton, C., Mukaetova-Ladinska, E., Arendt, Th. and Wischik, C. M. Examination of the validity of the hierarchical model of neuropathological staging in normal aging and Alzheimer’s disease. Acta Neuropathol. 95 (1998) 154-158.
Janke, C., Gärtner, U., Fruth, R., Holzer, M. and Arendt, Th. Reversible in vivo phos­phoryla­tion of tau induced by okadaic acid and by unspecific brain lesion in rat. J. Brain Res. 39 (1998) 143-153.
Lüth, H.-J. et Arendt, Th. Oxyde Nitrique et maladie d’Alzheimer. Alzheimer Actualités, No. 132 (1998) 6-11.
Lüth, H.-J. and Arendt, Th. Nitric oxide and Alzheimer´s disease. J. Brain Research 39 (1998) 245-251.
Nitsch, R. M., Rossner, S., Albrecht, C., Mayhaus, M., Enderich, J., Schliebs, R., Weg­ner, M. Arendt, Th. and von der Kammer, H. Muscarinic acetylcholine receptors acti­vate the acetylcholinesterase gene promotor. J. Physiol. Paris 92 (1998) 257-264.
Thal, D. R., Arendt, Th., Waldmann, G., Holzer, M., Zedlick, D., Rüb, U. and Schober, R. Progression of neurofibrillary changes and PHF-? in end-stage Alzheimer’s disease is dif­ferent from plaque and cortical microglial pathology. Neurobiology of Aging 19 (1998) 517-525.
Wolf, H., Grunwald, M., Ecke, G.M., Zedlick, D., Bettin, S., Danneberg C, Dietrich J, Eschrich K., Arendt, Th, Gertz, H.-J. The prognosis of mild cognitive impairment in the el­d­erly. J. Neural. Transmission, Suppl. 54, (1998) 31-50.
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