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Publikationen der AbteilungMolekulare Bildgebung des ZNS
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2011
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Hartlage-Rubsamen M, Morawski M, Waniek A, Jager C, Zeitschel U, Koch B, Cynis H, Schilling S, Schliebs R,
Demuth HU, Rossner S
Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms.
Acta Neuropathol 2011; 121: 705-719
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Hawkes CA, Härtig W, Kacza J, Schliebs R, Weller RO, Nicoll JA, Carare RO
Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid
angiopathy.
Acta Neuropathol 2011; 121(4): 431-443
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Kasabov NK, Schliebs R, Kojima H
Probabilistic computational neurogenetic modeling: from cognitive systems to Alzheimer\'s disease.
IEEE Transactions on Autonomous Mental Development 2011; 3(4): 300-311
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Schliebs R, Arendt T
The cholinergic system in aging and neuronal degeneration.
Behav Brain Res 2011; 221: 555-563
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Zarazua S, Bürger S, Delgado JM, Jimenez-Capdeville ME, Schliebs R
Arsenic affects expression and processing of amyloid precursor protein (APP) in primary neuronal cells overexpressing the Swedish mutation of human APP.
Int J Dev Neurosci 2011; 29(4): 389-396
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2010
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Bürger S, Yafai Y, Bigl M, Wiedemann P, Schliebs R
Effect of VEGF and its receptor antagonist SU-5416, an inhibitor of angiogenesis, on processing of the ß-amyloid precursor protein in primary neuronal cells derived from brain tissue of Tg2576 mice.
Int J Dev Neurosci 2010; 28(7): 597-604
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Donat CK, Walter B, Kayser T, Deuther-Conrad W, Schliebs R, Nieber K, Bauer R, Härtig W, Brust P
Effects of lateral fluid percussion injury on cholinergic markers in the newborn piglet brain.
Int J Dev Neurosci 2010; 28(1): 31-38
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Ebert S, Goos M, Rollwagen L, Baake D, Zech WD, Esselmann H, Wiltfang J, Mollenhauer B, Schliebs R, Gerber J, Nau R
Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.
J Neurosci Res 2010; 88(5): 1124-1136
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Glavan G, Schliebs R, Zivin M
Synaptotagmins in neurodegeneration.
Anat Rec (Hoboken) 2010; 292(12): 1849-1862
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Ihunwo AO, Schliebs R
Cell proliferation and total granule cell number in dentate gyrus of transgenic Tg2576 mouse.
Acta Neurobiol Exp (Wars) 2010; 70(4): 362-369
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Kara F, Braakman N, van Buchem MA, de Groot HJ, Schliebs R, Alia A
In vivo longitudinal monitoring of blood flow alterations in Tg2576 mouse model of Alzheimer’s disease.
Proc Intl Soc Magn Reson Med 2010; 18: 4273
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Morawski M, Pavlica S, Seeger G, Grosche J, Kouznetsova E, Schliebs R, Brückner G, Arendt T
Perineuronal nets are largely unaffected in Alzheimer model Tg2576 mice.
Neurobiol Aging 2010; 31(7): 1254-1256
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Plaschke K, Kopitz J, Siegelin M, Schliebs R, Salkovic-Petrisic M, Riederer P, Hoyer S
Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice.
J Alzheimers Dis 2010; 19(2): 691-704
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Schliebs R
Molecular mechanisms of cholinergic dysfunction in Alzheimer’s disease – cell culture and animal approches. Universidad de Guadalajara, 2010, pp.
In: Ortuño Sahagún D, Beas Zarate C, Armendáriz J, Pallad Lliberia M, Camins A: Tópicos de Actuación en Neurobilogía: Biología molecular del desarollo, neurodegeneración y medicina genómica
Universidad de Guadalajara, Guadalajara (2010); 129-146
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2009
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Augustin S, Rimbach G, Augustin K, Schliebs R, Wolffram S, Cermak R
Effect of a short- and long-term treatment with Ginkgo biloba extract on amyloid precursor protein levels in a transgenic mouse model relevant to Alzheimer's disease.
Arch Biochem Biophys 2009; 481(2): 177-182
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Bürger S, Noack M, Kirazov LP, Kirazov EP, Naydenov CL, Kouznetsova E, Yafai Y, Schliebs R
Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and beta-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain.
Int J Dev Neurosci 2009; 27(6): 517-523
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Rivera-Cervantes MC, Flores-Soto ME, Chaparro-Huerta V, Reyes-Gomez J, Feria-Velasco A, Schliebs R, Beas-Zarate C
Changes in hippocampal NMDA-R subunit composition induced by exposure of neonatal rats to L-glutamate.
Int J Dev Neurosci 2009; 27(2): 197-204 |
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Sorger D, Scheunemann M, Vercouillie J, Grossmann U, Fischer S, Hiller A, Wenzel B, Roghani A, Schliebs R, Steinbach J, Brust P, Sabri O
Neuroimaging of the vesicular acetylcholine transporter by a novel 4-[18F]fluoro-benzoyl derivative of 7-hydroxy-6-(4-phenyl-piperidin-1-yl)-octahydro-benzo[1,4]oxazines.
Nucl Med Biol 2009; 36(1): 17-27
ISSN 0969-8051
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Walther T, Albrecht D, Becker M, Schubert M, Kouznetsova E, Wiesner B, Maul B, Schliebs R, Grecksch G, Furkert J, Sterner-Kock A, Schultheiss HP, Becker A, Siems WE
Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase.
PLoS One 2009; 4(2): 1-10
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2008
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Augustin S, Huebbe P, Matzner N, Augustin K, Schliebs R, Cermak R, Wolffram S, Rimbach G
Ginkgo biloba extract and its flavonol and terpeneloctone fractions do not affect beta-secretase mRNA and enzyme activity levels in cultured neurons and in mice.
Planta Med 2008; 74: 6-13
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Baier M, Apelt J, Riemer C, Gultner S, Schwarz A, Bamme T, Burwinkel M, Schliebs R
Prion infection of mice transgenic for human APP(Swe): increased accumulation of cortical formic acid extractable Abeta(1-42) and rapid scrapie disease development.
Int J Dev Neurosci 2008; 26(7): 821-824
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Bigl K, Gaunitz F, Schmitt A, Rothemund S, Schliebs R, Munch G, Arendt T
Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation.
J Neural Transm 2008; 115(11): 1545-1556
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Fiedorowicz A, Figiel I, Zaremba M, Dzwonek K, Schliebs R, Oderfeld-Nowak B
Trimethyltin-evoked apoptosis of murine hippocampal granule neurons is accompanied by the expression of interleukin-1beta and interleukin-1 receptor antagonist in cells of ameboid phenotype, the majority of which are NG2-positive.
Brain Res Bull 2008; 77(1): 19-26
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Herrmann P, Druckrey-Fiskaaen C, Kouznetsova E, Heinitz K, Bigl M, Cotman SL, Schliebs R
Developmental impairments of select neurotransmitter systems in brains of Cln3(Deltaex7/8) knock-in mice, an animal model of juvenile neuronal ceroid lipofuscinosis.
J Neurosci Res 2008; 86: 1857-1870
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Joerchel S, Raap M, Bigl M, Eschrich K, Schliebs R
Oligomeric beta-amyloid(1-42) induces the expression of Alzheimer disease-relevant proteins in cholinergic SN56.B5.G4 cells as revealed by proteomic analysis.
Int J Dev Neurosci 2008; 26: 301-308
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Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A,
Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D ... Rossner S
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.
Nat Med 2008; 14(10): 1106-1111
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Sorger D, Scheunemann M, Grossmann U, Fischer S, Vercouille J, Hiller A, Wenzel B,
Roghani A, Schliebs R, Brust P, Sabri O, Steinbach J
A new 18F-labeled fluoroacetylmorpholino derivative of vesamicol for neuroimaging of the vesicular acetylcholine transporter.
Nucl Med Biol 2008; 35: 185-195
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2007
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Donat CK, Schuhmann MU, Voigt C, Nieber K, Schliebs R, Brust P
Alterations of acetylcholinesterase activity after traumatic brain injury in rats.
Brain Inj 2007; 21(10): 1031-1037
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Gil-Bea FJ, Aisa B, Schliebs R, Ramirez MJ
Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice.
Behav Neurosci 2007; 121(2): 340-344
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Ihunwo AO, Luth HJ, Schliebs R, Kayanja FIB
Ultrastructural Features of Beta-Amyloid Plaques in Aged Transgenic Tg2576 Mouse Brain with Alzheimer Plaque Pathology
Res J Med Sci 2007; 1(2): 55-61
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Scheunemann M, Sorger D, Kouznetsova E, Sabri O, Schliebs R, Wenzel B, Steinbach J
Wequential ring-opening of trans-1,4-cyclohexadiene dioxide for an
expedient modular approach to 6,7-disubstituted
(+/-)-hexahydro-benzo[1,4]oxazin-3-ones
Tetrahedron Lett 2007; 48(31): 5497-5501
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Sorger D, Becker GA, Patt M, Schildan A, Grossmann U, Schliebs R, Seese A, Kendziorra K,
Kluge M, Brust P, Mukhin AG, Sabri OMeasurement
of the alpha4beta2* nicotinic acetylcholine receptor ligand
2-[(18)F]Fluoro-A-85380 and its metabolites in human blood during PET
investigation: a methodological study.
Nucl Med Biol 2007; 34(3): 331-342
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Yun SW, Kouznetsova E, Nitschke C, Heinitz K, Schliebs R, Gerlach M, Riederer P,
Klein MA
beta-Amyloid deposition and prion infection in adult primary brain cell long-term culture model.
Biochem Biophys Res Commun 2007; 360(3): 520-524
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2006
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Alpar A, Gartner U, Hartig W, Bruckner G
Distribution of pyramidal cells associated with perineuronal nets in the neocortex of rat.
Brain Res 2006; 1120(1): 13-22
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Braakman N, Matysik J, van Duinen SG, Verbeek F, Schliebs R, de Groot HJ, Alia ALongitudinal
assessment of Alzheimer's beta-amyloid plaque development in transgenic
mice monitored by in vivo magnetic resonance microimaging.
J Magn Reson Imaging 2006; 24(3): 530-536
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Bruckner G, Pavlica S, Morawski M, Palacios AG, Reichenbach A
Organization of brain extracellular matrix in the Chilean fat-tailed mouse opossum Thylamys elegans (Waterhouse, 1839).
J Chem Neuroanat 2006; 32: 143-158
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Bruckner G, Szeoke S, Pavlica S, Grosche J, Kacza J
Axon initial segment ensheathed by extracellular matrix in perineuronal nets.
Neuroscience 2006; 138: 365-375
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Flores-Soto ME, Banuelos-Pineda J, Orozco-Suarez S, Schliebs R, Beas-Zarate C
Neuronal damage and changes in the expression of muscarinic acetylcholine receptor subtypes
in the neonatal rat cerebral cortical upon exposure to sparteine, a quinolizidine alkaloid.
Int J Dev Neurosci 2006; 24(6): 401-410
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Franke H, Grummich B, Hartig W, Grosche J, Regenthal R, Edwards RH, Illes P, Krugel U
Changes in purinergic signaling after cerebral injury - involvement of glutamatergic mechanisms?
Int J Dev Neurosci 2006; 24: 123-132
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Hartig W, Lehmann J, Stieler J, Singer D, Grosche J, Arendt T, Hoffmann R
Simultaneous detection of tau phospho-epitopes with haptenylated antibodies.
Neuroreport 2006; 17(9): 869-874
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Heinitz K, Beck M, Schliebs R, Perez-Polo JR
Toxicity mediated by soluble oligomers of beta-amyloid(1-42) on cholinergic SN56.B5.G4 cells.
J Neurochem 2006; 98(6): 1930-1945
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Kouznetsova E, Klingner M, Sorger D, Sabri O, Grossmann U, Steinbach J, Scheunemann M,
Schliebs R
Developmental and amyloid plaque-related changes in cerebral cortical capillaries in transgenic Tg2576
Alzheimer mice.
Int J Dev Neurosci 2006; 24: 187-193
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Liskowsky W, Schliebs R
Muscarinic acetylcholine receptor inhibition in transgenic Alzheimer-like Tg2576 mice by
scopolamine favours the amyloidogenic route of processing of amyloid precursor protein.
Int J Dev Neurosci 2006; 24: 149-156
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Nowak K, Lange-Dohna C, Zeitschel U, Günther A, Lüscher B, Robitzki A, Perez-Polo R,
Rossner S
The transcription factor Yin Yang 1 is an activator of BACE1 expression.
J Neurochem 2006; 96: 1696-1707
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Rossner S, Sastre M, Bourne K, Lichtenthaler SF
Transcriptional and translational regulation of BACE1 expression-Implications for Alzheimer's
disease.
Prog Neurobiol 2006; 79(2): 95-111
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Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO,
Dumitrescu-Ozimek L, Thal DR, LandrethG, Walter J, Klockgether T, van Leuven F, Heneka MT
Nonsteroidal anti-inflammatory drugs repress ß-secretase gene promoter activity by the activation
of PPARgamma. PNAS USA 2006; 103(2): 443-448
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Schliebs R
Neural signal transduction in health and disease-cytokines, mitochondrial dysfunction and transport processes.
Int J Dev Neurosci 2006; 24: 87-89
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Schliebs R, Arendt T
The significance of the cholinergic system in the brain during aging and in Alzheimer's disease.
J Neural Transm 2006; 113(11): 1625-1644
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Schliebs R, Heidel K, Apelt J, Gniezdzinska M, Kirazov L, Szutowicz AInteraction
of interleukin-1beta with muscarinic acetylcholine receptor-mediated
signaling cascade in cholinergically differentiated SH-SY5Y cells.
Brain Res 2006; 1122(1): 78-85
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Shemer I, Holmgren C, Min R, Fulop L, Zilberter M, Sousa KM, Farkas T, Hartig W,
Penke B, Burnashev N, Tanila H, Zilberter Y, Harkany TNon-fibrillar
beta-amyloid abates spike-timing-dependent synaptic potentiation at
excitatory synapses in layer 2/3 of the neocortex by targeting
postsynaptic AMPA receptors.
Eur J Neurosci 2006; 23(8): 2035-2047
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Siegemund T, Paulke BR, Schmiedel H, Bordag N, Hoffmann A, Harkany T, Tanila H, Kacza J,
Hartig W
Thioflavins released from nanoparticles target fibrillar amyloid beta in the hippocampus
of APP/PS1 transgenic mice.
Int J Dev Neurosci 2006; 24: 195-201
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Singer D, Lehmann J, Hanisch K, Hartig W, Hoffmann R
Neighbored phosphorylation sites as PHF-tau specific markers in Alzheimer's disease.
Biochem Biophys Res Commun 2006; 346(3): 819-828
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Sorger D, Becker GA, Hauber K, Schildan A, Patt M, Birkenmeier G, Otto A, Meyer P,
Kluge M, Schliebs R, Sabri OBinding
properties of the cerebral alpha4beta2 nicotinic acetylcholine receptor
ligand 2-[(18)F]fluoro-A-85380 to plasma proteins.
Nucl Med Biol 2006; 33(7): 899-906
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Stahl T, Reimers C, Johne R, Schliebs R, Seeger JViral-induced
inflammation is accompanied by beta-amyloid plaque reduction in brains
of amyloid precursor protein transgenic Tg2576 mice.
Eur J Neurosci 2006; 24(7): 1923-1934
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Zuchner T, Schliebe N, Schliebs R
Zinc uptake is mediated by M1 muscarinic acetylcholine receptors in differentiated SK-SH-SY5Y cells.
Int J Dev Neurosci 2006; 24: 23-27
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2005
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Betz T, Teipel J, Koch D, Hartig W, Guck J, Kas J, Giessen H
Excitation beyond the monochromatic laser limit: simultaneous 3-D confocal and multiphoton
microscopy with a tapered fiber as white-light laser source.
J Biomed Opt 2005; 10(5): 54009-
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Günther A, Küppers-Tiedt L, Schneider PM, Kunert I, Berrouschot J, Schneider D, Rossner S
Reduced infarct volume and differential effects on glial cell activation
after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia.
Eur J Neurosci 2005; 21: 3189-3194
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Härtig W, Oklejewicz M, Strijkstra AM, Boerema AS, Stieler J, Arendt T
Phosphorylation of the tau protein sequence 199-205 in the hippocampal CA3 region of
Syrian hamsters in adulthood and during aging.
Brain Res 2005; 1056: 100-104
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Harkany T, Dobszay MB, Cayetanot F, Härtig W, Siegemund T, Aujard F, Mackie K
Redistribution of CB1 Cannabinoid Receptors During Evolution of Cholinergic Basal
Forebrain Territories and their Cortical Projection Areas: A Comparison Between the Gray Mouse
Lemur (Microcebus murinus, Primates) and Rat.
Neurosci 2005; 135: 595-609
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Hobohm C, Günther A, Grosche J, Rossner S, Schneider D, Brückner G
Decomposition and Long-Lasting Downregulation of Extracellular Matrix in Perineuronal Nets
Induced by Focal Cerebral Ischemia in Rats.
J Neurosci Res 2005; 80(4): 539-548
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Kirazov L, Kirazov E, Schliebs R
L-Glutamate and phorbol ester stimulate the release of secretory amyloid precursor protein from rat cortical synaptosomes.
Acta Biol Hung 2005; 56: 177-183
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Schliebs RBasal forebrain cholinergic lesion by 192IgG-saporin:
a tool to asses the consequences of cortical cholinergic dysfunction in
Alzheimer`s disease.
In: Willey RG, Lappi DA: Molecular Neurosurgery with Targeted Toxins
The Humana Press Inc, Totowa, NJ (2005); 59-86
ISBN 1-58829-199-5
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Schliebs RBasal forebrain cholinergic dysfunction in Alzheimer`s
disease - interrelationship with ß-amyloid, inflammation and
neurotrophin signaling.
Neurochem Res 2005; 30: 895-908
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Rossner S, Lange-Dohna C, Zeitschel U, Perez-Polo JR
Alzheimer's disease ß-secretase BACE1 is not a neuron-specific enzyme.
J Neurochem 2005; 92: 226-234
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Rossner S, Schulz I, Zeitschel U, Schliebs R, Bigl V, Demuth HU
Brain Prolyl Endopeptidase Expression in Aging, APP Transgenic Mice and Alzheimer's Disease.
Neurochemical Research 2005; 30: 695-702
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Schulz I, Zeitschel U, Rudolph T, Ruiz-Carrillo D, Rahfeld JU, Gerhartz B, Bigl V,
Demuth HU, Rossner S
Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion.
J Neurochem 2005; 94: 970-979
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Schutz A, Hartig W, Wobus M, Grosche J, Wittekind Ch, Aust G
Expression of ADAM15 in lung carcinomas.
Virchows Arch 2005; 446(4): 421-429
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Wenzel B, Sorger D, Heinitz K, Scheunemann M, Schliebs R, Steinbach J, Sabri O
Structural changes of benzylether derivatives of vesamicol and their influence on the binding
selectivity to the vesicular acetylcholine transporter.
Eur J Med Chem 2005; 40(12): 1197-1205
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Züchner T, Schliebs R, Perez-Polo JRDownregulation off
muscarinic acetylcholine receptor M2 adversely affects in expression of
Alzheimer`s disease relevant genes and proteins.
J Neurochem 2005; 95: 20-32
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2004
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Apelt J, Bigl M, Wunderlich P, Schliebs R Aging-related increase
in oxidative stress correlates with developmental pattern of
beta-secretase activvity and beta-amyloid plaque formation in
transgenic Tg2576 mice with Alzheimer-like pathology.
Int. J. Devl Neuroscience 2004; 22(7): 475-484
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Brückner G, Kacza J, Grosche J Perineuronal nets characterized
by vital labelling, confocal and electron microscopy in organotypic
slice cultures of rat parietal cortex and hippocampus.
J Mol Histol 2004; 35: 115-122
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Rossner S, Fuchsbrunner K, Lange-Dohna C, Hartlage-Rübsamen M, Bigl V, Betz A, Reim K, Brose N
Munc13-1-mediated vesicle priming contributes to secretory APP processing.
J Biol Chem 2004; 279(27): 27841-27844
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Morawski M, Brückner M, Riederer P, Brückner G, Arendt T
Perineuronal nets potentially protect against oxidative stress.
Exp Neurol 2004; 188: 309-315
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Alpár A, Seeger G, Härtig W, Arendt T, Gärtner U
Adaptive morphological changes of neocortical interneurons in response to enlarged and more
complex pyramidal cells in p21H-Ras Val12 transgenic mice.
Brain Res Bull 2004;62(4): 335-343
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Züchner T, Perez-Polo JR, Schliebs R
Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor
signalling.
J Neurosci Res 2004; 77: 250-257
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Arendt T, Stieler J, Strijkstra AM, Hut RA, Van der Zee EA, Holzer M, Härtig W
Hibernation in Mammals: A Model for Alzheimer-type Phosphorylation of the Microtubule-associated
Protein Tau.
Life in the Cold Evolution, Mechanisms, Adaptation and Application. Twelfth International
Hibernation Symposium Juli 25-August 1 2004; 27: 497-507
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Rossner S
New players in old amyloid precursor protein-processing pathways.
Int J Dev Neurosci 2004; 22(7): 467-474
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Alpár A, Gärtner U, Seeger G, Härtig W, Brauer K, Arendt T
Constitutive Expression of p21H-ras Val12 in Pyramidal Neurons Results in Reorganization of
Mouse Neocortical Afferents.
J Neurobiol 2004; 60(3): 263-274
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Schliebs
Molecular mechanisms of neurodegeneration and neuroprotection - experimental approaches and
the diseased brain. Editorial.
Int J Dev Neurosci 2004; 22(7): 441-442
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Blasko I, Beer R, Bigl M, Apelt J, Franz G, Rudzki D, Ransmayr G, Kampfl A, Schliebs R
Experimental traumatic brain injury in rat stimulates the expression, production and activity
of Alzheimer's desease ß-secretase (BACE-1).
J Neuroal Transm 2004; 111(4): 523-536
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Franke H, Günther A, Grosche J, Schmidt R, Rossner S, Reinhardt R, Faber-Zuschratter H, Schneider D, Illes P
P2X7 receptor expression after ischemia in the cerebral cortex of rats.
J Neuropathol Exp Neurol 2004; 63(7):686-699
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Scheunemann M, Sorger D, Wenzel B, Heinitz K, Schliebs R, Klingner M, Sabri O, Steinbach J
Synthesis of novel 4- and 5-substituted benzyl ether derivatives of vesamicol and in vitro
evaluation of their binding properties to the vesicular acetylcholine transporter site.
Bioorg Med Chem 2004; 12(6): 1459-1465
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Berghuis P, Dobszay MB, Sousa KM, Schulte G, Mager PP, Härtig W, Görcs TJ, Zilberter Y, Ernfors P, Harkany T
Brain-derived neurotrophic factor controls functional differentiation and microcircuit
formation of selectively isolated fast-spiking GABAergic interneurons.
Eur J Neurosci 2004; 20(5): 1290-1306
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Franke H, Krügel U, Grosche J, Heine C, Härtig W, Allgaier C, Illes P
P2Y Receptor Expression on Astrocytes in the nucleus Accumbens of Rats.
Neuroscie 2004; 127(2): 431-441
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Harkany T, Holmgren C, Härtig W, Quereshi T, Chaudhry FA,
Storm-Mathisen J, Dobszay MB, Berghuis P, Schulte G, Sousa KM, Fremeau
Jr RT, Edwards RH, Mackie K, Ernfors P, Zilberter Y
Endocannabinoid-Independent Retrograde Signaling at Inhibitory Synapses in Layer 2/3 of
Neocortex: Involvement of Vesicular Glutamate Transporter .3
J Neurosci 2004; 24: 4978-4988
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Schliebs R
Basal Forebrain Cholinergic Lession by 192IgG-Saporin A Tool to Asses
the consequences of
Cortical Cholinergic Dysfunction in Alzheimer's disease.
In: Wiley RG, Lappi DA: Molecular Neurosurgery With Targeted Toxins
Humana Press Totowa, New Jersey (2004); 59-86, ISBN 1-58829-199-5
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Härtig W, Schmiedel H, Siegemund T, Wang R, Paulke BR, Pranzas KP, Eckerlebe H
SANS Study of Negatively Charged 'Hairy' Latex: Particles Condensed Matter Physics with
Neutrons at the IBR-2 Pulsed Reactor.
In: Joint Institute for Nuclear Research: Germany-JINR User Meeting
Joint Institute for Nuclear Research, dubna (2004; 66-70, ISBN 5-9530-0065-0
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2003
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Apelt, J.; Ach, K.; Schliebs, R.:
Aging-related down-regulation of neprilysin, a putative b-amyloid-degrading enzyme, in
transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in
the vicinity of b-amyloid plaques.
Neurosci. Lett. 339 2003 183-186.
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Arendt, Th,.;Stieler, J.; Strijkstra, AM.; Hut, RA.; Rüdiger, J.; Van der Zee, EA.; Harkany, T.;Holzer, M.: Härtig, W.:
Reversible PHF-like phosphorylation of tau is an adaptive process associated with neuronal
plasticity in hibernating animals.
J Neurosci 2003; 23(18): 6972-6981
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Beck, M.; Bigl, V.; Rossner S.:
Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo.
Neurochem. Res. 2003; 28: 637-644, .
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Bigl, V.; Rossner, S.
Amyloid precursor protein processing in vivo - insights from a chemically-induced constitutive
overactivation of protein kinase C in guinea pig brain.
Curr. Med. Chem. 2003; 10: 871-882,
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Bigl, M.; Apelt, J.; Eschrich, K.; Schliebs, R.:
Cortical glucose metabolism is altered in aged transgenic Tg2576 mice that demonstrate
Alzheimer plaque pathology.
J. Neural Transm. 2003; 110: 77-94.
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Brückner, G., Grosche, J., Hartlage-Rübsamen, M., Schmidt, S., Schachner, M.
Region and lamina-specific distribution of extracellular matrix proteoglycans, hyaluronan and
tenascin-R in the mouse hippocampal formation. J. Chem. Neuroanat. 2003;26 (4): 37-50
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Francke, M.; Uhlmann, S.; Pannicke, T.; Goczalik, I.; Uckermann, O.;
Weick, M.; Härtig, W.; Wiedemann, P.; Reichenbach, A.; Bringmann, A.:
Experimental dispase-induced retinopathy causes an up-regulation of P2Y receptor mediated
calcium responses in Müller glial cells.
Ophthalmic Res 2003; 35: 30-41.
| |
Härtig W, Riedel A, Grosche J, Edwards R, Remeau R, Harkany T, Brauer K, Arendt Th
Complementary distribution of Vesicular Glutamate Transporters 1 and 2 in the Nucleus
Accumbens of Rat: Relationship to Calretinin-Containing Extrinsie Innervation and
Calbindin-Immunoreactive Neurons.
J Comp Neurol 2003; 465: 1-1
| |
Hanani, M.; Ledder, O.; Yutkin, V.; Abu-Dalu, R.; Huang ,T-Y.; Härtig, W.; Vannucci, M-G.; Faussone-Pellegrini, M-S.:
Regeneration ofmyenteric plexus in the mouse colon after experimental denervation with
benzalkonium chloride.
J Comp Neurol 2003; 462: 315-327
| |
Hartlage-Rübsamen, M.; Zeitschel, U.; Apelt, J.; Gärtner, U.; Franke, H.; Stahl, T.; Günther,
A.; Schliebs, R.; Penkowa, M.; Bigl, V.; Rossner S.:
Astrocytic expression of the Alzheimer's disease b-secretase (BACE) is stimulus-dependent.
Glia 2003; 41:169-179, .
| |
Härtig, W.; Paulke, B-R.; Varga, C.; Seeger, J.; Harkany, T.; Kacza ,J.:
Electron microscopic analyses of nanoparticles delivering thioflavin-T after intrahippocampal
injection in mice: Implications for targeting ß-amyloid in Alzheimer's disease.
Neurosci Lett 2003; 338:174-176.
| |
Horn, A.K.; Brückner, G.; Härtig, W.; Messoudi, A.:
Saccadic omnipause and burst neurons in monkey and human are ensheathed
by perineuronal nets but differ in their expression of calcium-binding
proteins.
J. Comp. Neurol. 2003; 467 341-352
| |
Klingner M, Apelt J, Kumar A, Sorger D, Sabri O, Steinbach I, Scheunemann M, Schliebs R
Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in
transgenic Tg2576 mouse brain with beta-amyloid plaque pathology.
Int J Devl Neurosci 2003; 21: 357-369
| |
Lange-Dohna, C. ; Zeitschel, U. ; Gaunitz, F. ; Perez-Polo, R. ; Bigl ; V., Rossner S. :
Cloning and expression of the rat BACE1 promoter.
J. Neurosci. Res. 2003; 73 (1): 73-80
| |
Lüth, H-L.; Apelt, J.; Ihunwo, A.; Schliebs, R.:
Specific degeneration of b-amyloid-associated cholinergic structures in transgenic APPSW mice.
Brain Res. 2003; 977: 16-22
| |
Münch, M.; Apelt, J.; Kientsch-Engel, R.; Stahl, P.; Lüth, H-L.; Schliebs, R.:
Advanced glycation endproducts (AGEs) and pro-inflammatory cytokines in transgenic Tg2576 mice
with amyloid plaque pathology.
J. Neurochem 2003; 86: 283-289
| |
Nikonenko, A., Schmidt, S., Skibo, G., Brückner, G., Schachner, M. (2003)
Tenascin-R deficient mice show structural alterations of symmetric perisomatic synapses in
the CA1 region of the hippocampus.
J. Comp. Neurol. 2003; 456: 338-349
| |
Varga C, Härtig W, Grosche J, Keijser J, Luiten PGM, Seeger J, Brauer K und Harkany T:
The rabbit forebrain cholinergic system: Morphological characterization of nuclei and
distribution of cholinergic terminals in the cerebral cortex and hippocampus.
J Comp Neurol 2003; 460: 597-611.
| |
Wegner, F., Härtig, W., Bringmann, A., Grosche, J., Wohlfarth, K., Zuschratter, W., Brückner, G.:
Diffuse perineuronal nets and modified pyramidal cells immunoreactive
for glutamate and the GABAA receptor alpha-1 subunit form a unique entity in rat cerebral
cortex.
Exp. Neurol.2003; 184: 705-714
| |
Harkany T, Härtig W, Berghuis P, Zilberter Y, Edwards RH, Mackie K, Ernfors P Complementary
distribution of type 1 cannabinoid receptors and vesicular glutamate
transporter 3 in basal forebrain suggests input-specific retrograde
signalling by cholinergic neurons
Eur J Neurosci 2003; 18: 1979-1992
| |
Tomaszewicz M, Rossner S, Schliebs R, Ewikowska J, Szutowicz A
Changes in cortical acetyl-CoA metabolsm after selective basal forebrain cholinergic
degeneration by 192IgG-saporin.
J Neurochem 2003; 87: 318-324
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2002
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Apelt, J.,Leßig, J and Schliebs, R.:
ß-Amyloid-associated expression of intercellular adhesion molecule-1(ICAM-1) in brain cortical tissue of transgenic Tg2576 mice.
Neurosci.Lett. 329(2002) 111-115
| |
Apelt, J., Kumar, A. and Schliebs, R.:Impairment of cholinergic
neurotransmission in adult and aged transgenic Tg2576 mouse brain
expressing the Swedish mutation of human ß-amyloid precursor protein.
Brain Res. 953(2002) 17-30
| |
Gerlach, R.; Beck, M.; Zeitschel,U; Seifert, V.:
MK801 attenuates c-Fos and c-Jun expression after in vitro ischemia in rat neuronal cell cultures but not in PC 12 cells
Neurol Res 24,7(2002)725-729
| |
Gärtner, U., Härtig, W., Brauer, K., Riedel, A. and Arendt, Th.:Immunocytochemical
evidence for the striatal nature of the rat lateral part of
interstitial nucleus of the posterior limb of the anterior commissure
(IPAC).
J Chem Neuroanat 24(2002) 117-125
| |
Horvath, KM., Härtig, W., van der Veen, R., Keijser, J.N., Mulder,
J., Ziegert, M., van der Zee, E.A., Harkany, T. and Luiten, PGM.:
17b-estradiol enhances cortical cholinergic innervation and preserves
synaptic density following excitotoxic lesions in the rat nucleus
basalis magnocellularis.
Neuroscience 110 (2002) 489-504
| |
Harkany, T., Varga, C., Grosche, J., Mulder, J., Penke, B., Hortobágyi, T., Luiten, PGM and Härtig, W.:
Distinct subsets of nucleus basalis neurons exhibit similar sensitivity to excitotoxicity
NeuroReport 13(2002)767-772
| |
Holzer, M., Gärtner, U., Stöbe, A., Härtig, W., Gruschka, H., Brückner, MK. and Arendt, Th.:
Inverse association of Pin1 and tau accumulation in Alzheimers disease hippocampus. Acta Neuropathol 104(2002) 471-481
| |
W. Härtig, A. Bauer, K. Brauer, J. Gosche, T. Hortobagyi, B. Penke, R. Schliebs and T. Harkany:
Functional recovery of cholinergic basal forebrain neurons under disease conditions: Old problems, new solutions?
Rev. Neurosci. 13 (2002) 95-165
| |
Härtig, W., Varga, C., Kacza, J., Grosche, J., Seeger, J., Luiten, PGM., Brauer, K. and Harkany, T.:
In vivo labeling of rabbit cholinergic basal forebrain neurons with fluorochromated antibodies. NeuroReport 13(2002) 1395-1398
| |
Luschekina, E.A., Bigl, M., Apelt, J., Lange-Dohna, C.,Rossner, St. and R. Schliebs:
Expression of beta-secret?se mRNA in brain of rats with immunohistochemical destruction of basal forebrain cholinergic system.
Bull. Exp. Biol. Med. 134 (2002) 236-240 (In Russian).
| |
Mager,P.P., Penke, B., Walter, R., Harkany, T. and Härtig, W.:
Pathological peptide folding in Alzheimer´s disease and other conformational disorders.
Curr. Med.Chem.9(2002)1763-1780
| |
Riedel, A., Härtig, W., Seeger, G., Gärtner, U., Brauer, K. and Arendt Th.:
Principles of rat subcortical forebrain organization: a study using histological techniques and multiple fluorescence labeling.
J Chem Neuroanat 23(2002) 75-104
| |
Schüppel, K., Brauer, K., Härtig, W., Grosche, J., Earley, B., Leonard, B.E. and Brückner, G.:Perineuronal
nets of extracellular matrix around hippocampal interneurons resist
destruction by activated microglia in trimethyltin-treated rats.
Brain Res 958(2002)448-453
| |
Zeitschel, U., Schliebs, R., Rossner, St., Bigl, V., Eschrich, K. and Bigl, M.:
Changes in activity and expression of phosphofructokinase in rat brain regions after basal forebrain cholinergic lesion.
J. Neurochem. 83 (2002) 371-380
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2001
| |
Adams, I., Brauer, K., Arélin, K, Härtig, W., Fine A., Mäder, M., Arendt, Th. and Brückner, G.
Perineuronal nets in the rhesus monkey and human basal forebrain including basal ganglia.
Neuroscience 108 (2001) 285-298.
| |
Apelt, J. and Schliebs, R.:b-Amyloid-induced glial expression of
both pro-and anti-inflammatory cytokines in cerebral cortex of aged
transgenic Tg2576 mice with Alzheimer plaque pathology.
Brain Res. 894 (2001) 21-30
| |
Brückner, G. and Grosche, J.:
Perineuronal nets show intrinsic patterns of extracellular matrix differentiation in
organotypic slice cultures.
Exp. Brain Res. 137 (2001) 83-93
| |
Gärtner, U., Härtig, W., Brauer, K., Brückner, G. and Arendt, Th.:
Electron microscopic evidence for differences in myelination of rat septo-hippocampal
parvalbumin-containing and cholinergic fibres.
Neuro Report 12 (2001) 17-20
| |
Gärtner, U., Härtig, W., Brauer, K., Brückner, G. and Arendt, Th.:
Immunofluorescence and immunoelectron microscopic evidence for differences
in myelination of GABAergic and cholinergic septohippocampal fibres.
Int. J. Devl. Neurosci. 19 (2001) 347-352
| |
Harkany, T., Grosche, J., Mulder, J., Horvathm K.M,. Keijser, J., Hortobagyi, T., Luiten, PGM. and Härtig, W.:
Short-term consequences of N-methyl-D-aspartate excitotoxicity in rat magnocellular
nucleus basalis: effects on in vivo labelling of cholinergic neurons.
Neuroscience 108 (2001) 611-627
| |
Hartlage-Rübsamen, M. and Schliebs, R.:Rat basal forebrain
cholinergic lesion affects neuronal nitric oxide synthase in
cholinoceptive hippocampal and neocortical target regions.
Brain Res. 889 (2001) 155-164.
| |
Hartlage-Rübsamen, M. and Schliebs, R.:Sequential upregulation
of cell adhesion molecules in degenerating rat basal forebrain
cholinergic neurons and in phagocytic microglial cells.
Brain Res. 897 (2001) 20-26.
| |
Hartlage-Rübsamen, M., Apelt, J. and Schliebs, R.:Fibrillary
beta-amyloid deposits produce atrophy of nitric oxide synthase
(NOS)-expressing neurons but do not upregulate the inducible NOS in
transgenic Tg2576 mice with Alzheimer pathology.
Neurosci. Lett. 302 (2001) 73-76.
| |
Härtig W; Klein, C., Brauer, K., Schüppel, K-F., Arendt, Th., Bigl ,V. and Brückner G.:
Hyperphosphorylated protein tau is restricted to neurons devoid of perineuronal nets in the cortex of aged bisons.
Neurobiol. Aging 22 (2001) 25-33
| |
Härtig, W., Singer, A., Grosche, J., Brauer, K., Ottersen, OP. and Brückner, G.
Perineuronal nets in the rat medial nucleus of the trapezoid body surround neuronal
elements immunoreactive for various amino acids, calcium-binding proteins and the
potassium channel subunit Kv3.1b.
Brain Res. 899 (2001) 123-133
| |
Kirazov, L., Kirazov, E., Bigl, V. and Schliebs, R.:Ontogenetic
changes in protein level of amyloid precursor protein (APP) in growth
cones and synaptosomes from rat brain and expression pattern of APP
mRNA isoforms in developing rat embryo.
Int. J. Devl. Neurosci. 19 (2001) 287-296.
| |
Krügel, U., Bigl, V., Eschrich, K. and Bigl, M.:
Deafferentation of the septo-hippocampal pathway in rats as a model of the metabolic events in Alzheimer´s disease
Int. J. Dev. Neurosci. 19 (2001) 263-277
| |
Löffler, T., Al-Robaiy, S., Eschrich, K. and Schliebs, R.:
Expression of fructose1,6-bisphoaphatase mRNA isoforms in normal and basal forebrain cholinergic lesioned rat brain.
Int. J. Devl. Neurosci. 19 (2001) 279-285.
| |
Löffler, T., Lee, S.K., Nöldner, M., Chatterjee, S.S., Hoyer, S. and Schliebs, R.:
Effect of Ginkgo biloba extract (EGb761) on glucose metabolism-related markers in streptozotocin-damaged rat brain.
J. Neural Transm.108 (2001) 1457-1474
| |
Mares, V. and Brückner G. :
Fucosylated glycans in the periventricular structures and the cerebrospinal fluid of the
fetal rat forebrain. An autoradiographic and lectin bindin histotopic study. Int. J. Dev.
Neurosci. 19(2001) 297-303
| |
Rossner, S., Mendla, K., Schliebs, R. and Bigl, V.:
Protein kinase Ca and b1 isoforms are regulators of ?-secretory proteolytic processing of amyloid precursor protein in vivo.
Eur. J. Neurosci. 13 (2001) 1644-1648.
| |
Rossner, S., Mehlhorn, G., Schliebs, R. and Bigl, V.:Increased
neuronal and glial expression of protein kinase C isoforms in neocortex
of transgenic Tg2576 mice with amyloid pathology.
Eur. J. Neurosci. 13 (2001) 269-278.
| |
Rossner, S., Apelt, J., Schliebs, R., Perez-Polo, J.R. and Bigl, V.:
Neuronal and glial b-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.
J. Neurosci. Res. 64 (2001) 437-446.
| |
Rossner, S., Brückner, M.K. and Bigl, V.:
Developmentally induced microencepahlopathy in guinea pigs - embryonic glial cell activation marks selective neuronal death.
Int. J. Devl. Neurosci. 19 (2001) 313-318.
| |
Schliebs, R.:
Editorial Neuronal plasticity and degeneration.
Int. J. Devl. Neurosci., 19 (2001) 229-230.
| |
Wouterlood ,FG., Grosche, J. and Härtig, W.:
Co-localization of calretinin and calbindin in distinct cells in the hippocampal formation of the rat.
Brain Res .922(2001) 310-314
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2000
| |
Beck, Mike; Brückner, Martina K.; Holzer, Max; Kaap, S; Pannicke, Thomas; Arendt, Thomas;
Bigl, VolkerGuinea-pig
primary cell cultures provide a model to study expression and
amyloidogenetic processing of endogenous amyloid precursor protein
Neuroscience 95(2000) 243-254
| |
Bigl, Marina; Apelt J; Luschekina, E A; Lange-Dohna, C; Rossner, Steffen; Schliebs, Reinhard
Expression of ß-secretase (BACE) mRNA in transgenic TG2576 mouse brain with Alzheimer plaque pathology
Neuroscience Letters 292(2000) 107-110
| |
Brauer, Kurt; Härtig, Wolfgang; Gärtner, Ulrich, Brückner, Gert; Arendt, Thomas
Different myelination of rat septohippocampal fibres as revealed by immunofluorescence double-labelling
Brain Research 878(2000) 188-193
| |
Brauer, Kurt; Häußer, Martina; Härtig, Wolfgang; Arendt, ThomasThe
core-shell dichotomy of nucleus accumbens in the rhesus monkey as
revealed by double-immunofluorescence and morphology of cholinergic
interneurons
Brain Research 858(2000) 151-162
| |
Brückner, Gert; Grosche, Jens; Schmidt, Sandra; Härtig, Wolfgang;
Margolis, Richard U.; Delpech, Bertrand; Seidenbecher, Constanze I.;
Czaniera, Reiner; Schachner, Melitta
Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R
The Journal of Comparative Neurology 428(2000)616-629
| |
Colombo, Jorge A.; Fuchs, Eberhard; Härtig, Wolfgang; Marotte, Lauren R.; Puissant, Virginia
"Rodent-like" and "primate-like" types of astroglial architecture in the adult cerebral cortex of mammals: a comparative study
Anatomy and Embryology 201(2000) 111-120
| |
Hanani, M; Francke, Mike; Härtig, Wolfgang; Grosche, Jens; Reichenbach, Andreas; Pannicke, Thomas
A patch-clamp study of neurons and glial cells in isolated myenteric ganglia
American Journal Physiol Gastrointest Liver Physiol 278(2000) G644-G651
| |
Härtig, Wolfgang; Klein, Christina; Brauer, Kurt; Schüppel, Karl-Friedrich; Arendt, Thomas; Brückner, Gert; Bigl, Volker
Abnormally phosphorylated protein tau in the cortex of aged individuals of various mammalian orders
Acta Neuropathologica 100(2000)305-312
| |
Holzer, Max; Brückner, Martina K.; Beck, Mike; Bigl, Volker; Arendt, Thomas
Modulation of APP processing and secretion by okadaic acid in primary guinea pig neurons
Journal of Neural Transmission 107(2000) 451-461
| |
Hoyer, S; Lee, S K; Löffler T; Schliebs, Reinhard
Inhibition of the neuronal insulin receptor. An in vivo-model for sporadic Alzheimer disease?
Molecular Genetics of Dementia(2000) 359-362
| |
Janke, Carsten; Beck, Mike; Holzer, Max; Bigl, Volker; Arendt, Thomas
Analysis of the molecular heterogeneity of the microtubule-associated protein tau by two-dimensional electrophoresis and RT-PCR
Brain Research Protocols 5(2000) 231-242
| |
Kacza, Johannes; Grosche, Jens; Seeger, Johannes; Brauer, Kurt; Brückner, Gert;
Härtig, Wolfgang
Laser scanning and electron microscopic evidence for rapid and specific
in vivo labelling of cholinergic neurons in the rat basal forebrain
with fluorochromated antobodies
Brain Research 867(2000) 232-238
| |
Kirazov, E; Kirazov, L; Venkov, L; Vassileva, E; Bigl, Volker; Schliebs, Reinhard
Changes in the expression and distribution of APP mRNA isoforms during embryonic development of rat brain
Compt. rend. Acad. bulg. Sci. 53(2000) 99-102, Heft 10
| |
Kirazov, L; Kirazov, E; Vassileva, E; Venkov, L; Schliebs, Reinhard; Bigl, Volker
Synaptosomes as a model system for studies on the secretion of the amyloid precursor protein
Compt. rend. Acad. bulg. Sci. 53(2000) 99-102, Heft 8
| |
Kirazov, L; Kirazov, E; Vassileva, E; Venkov, L; Schliebs, Reinhard; Bigl, Volker
Ontogenetic changes of amyloid precursor protein in homogenate, growth cones and synaptosomes from rat brain
Compt. rend. Acad. bulg. Sci. 53(2000) 97-100, Heft 9
| |
Mehlhorn, Gaby; Löffler, Thomas; Schliebs, Reinhard
Induction of cytokines in glial cells surrounding cortical ß-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology
International Journal of Developmental Neuroscience 18(2000)423-431
| |
Naumann, Thomas; Härtig, Wolfgang; Frotscher, MichaelRetrograde
tracing with Fluoro-Gold: Different methods of tracer detection at the
ultrastructural level and neurodegenerative changes of back-filled
neurons in long-term studies
Journal of Neuroscience Methods 103(2000) 11-21
| |
Rossner, Steffen; Schliebs, Reinhard; Bigl, VolkerIntracerebroventricular
infusion of CHO5, a rat monoclonal antibody directed against mouse
low-affinity nerve growth factor receptor (p75NTR), specifically labels
basal forebrain cholinergic neurons in mouse brain
Metabolic Brain Disease 15(2000) 17-27
| |
Rossner, S., Beck, M., Stahl, T., Mendla, K., Schliebs, R., Bigl V.Constitutive
overactivation of protein kinase C in guinea pig brain increases
a-secretory APP processing without decreasing b-amyloid generation.
Eur. J. Neurosci. 12 (2000) 3191-3200
| |
Sorger, Dietlinde; Schliebs, Reinhard; Kämpfer, Ingrid; Rossner, Steffen; Heinicke, J; Dannenberg, Claudia, Georgi, PIn
vivo [125I]-Iodobenzovesamicol binding reflects cortical cholinergic
deficiency induced by specific immunolesion of rat basak forebrain
cholinergic system.
Nuclear Medical Biology 27(2000) 23-31
| |
Tremere, Liisa A.; Pinaud, Raphael; Grosche, Jens; Härtig, Wolfgang; Rasmusson, Douglas D.
Antibody for human p75 LNTR identifies cholinergic basal forebrain of non-primate species
Neuroreport 11(2000) 2177-2183
|
Bücher
| |
Hoyer, Siegfried; Lee, Sae Kyung; Löffler Thomas; Schliebs, ReinhardInhibition
of the neuronal insulin receptor. An in vivo-model for sporadic
Alzheimer disease?
In: Molecular Genetics of Dementia (Growdon, H J; Wurtman, R J; Corkin
S; Nitsch, R M; editors), Proceedings of the Ninth Meeting of the
International Study Group on the Pharmacology of Memory Disorders
Associated with Aging. Switzerland, February 18-20
Cambridge, MA, USA
Center for Brain Sciences and Metabolism Charitable Trust (2000)
359-362
ISBN 1573312835
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1999
| |
Apelt, J.; Mehlhorn, G.; Schliebs, R.Insulin-sensitive GLUT4
glucose transporters are colocalized with GLUT3-expressing cells and
demonstrate a chemically distinct neuron-specific localization in rat
brain.
Journal of Neuroscience Research 57 (1999) 693-705
| |
Bigl, M.; Brückner, M. K.; Arendt, Th.; Bigl, V.; Eschrich, K.
Activities of key glycolytic enzymes in the brains of patients with Alzheimer´s disease.
Journal of Neural Transmission 106 (1999) 499-511
| |
Brauer, K.; Holzer, M.; Brückner, G.; Tremere, L.; Rasmusson, D. D.; Poethke, R.;
Arendt, Th.; Härtig, W.Two
distinct populations of cholinergic neurons in the septum of raccoon
(Procyon lotor): Evidence for a separate subset in the lateral septum.
The Journal of Comparative Neurology 412 (1999) 112-122
| |
Brückner, G.; Hausen, D.; Härtig, W.; Drlicek, M; Arendt, Th.; Brauer, K.Cortical
areas abundant in extracellular matrix chondroitin sulphate
proteoglycans are less affected by cytoskeletal changes in Alzheimer´s
disease.
Neuroscience 92 (1999) 791-805
| |
Härtig, W.; Derouiche, A.; Welt, K.; Brauer, K.; Grosche, J.; Mäder, M., Reichenbach, A.;
Brückner, G.Cortical
neurons immunoreactive for the potassium channel Kv3.1b subunit are
predominantly surrounded by perineuronal nets presumed as a buffering
system for cations.
Brain Research 842 (1999) 15-29
| |
Hanani, M.; Maudlej, N.; Härtig, W.
Morphology and intercellular communication in glial cells of intramural ganglia from the guinea-pig urinary bladder.
Journal of the Autonomic Nervous System 76 (1999) 62-67
| |
Hartlage-Rübsamen, M.; Lemke, R.; Schliebs, R.Interleukin-1ß,
inducible nitric oxide synthase, and nucleuar factor-?B are induced in
morphologically distinct microglia after rat hippocampal
lipopolysaccharide/interferon-? injection.
Journal of Neuroscience Research 57 (1999) 388-398
| |
Janke, C.; Beck, M.; Stahl, T.; Holzer, M.; Brauer, K.; Bigl, V.; Arendt, Th.Phylogenetic
diversity of the expression of the microtubule-associated protein tau:
implications for neurodegenerative disorders.
Molecular Brain Research 68 (1999) 119-128
| |
Kirazov, L.; Schliebs, R.; Bigl, V.
Influence of protease inhibitors on the secretion and the proteolytic processing of amyloid precursor protein.
Compt. rend. Acad. bulg. Sci. 52 (1999) 123-126
(erschienen in Bulgarien, kein Sonderdruck vorhanden)
| |
Kirazov, L.; Schliebs, R.; Bigl, V.Glutamate stimulates the
secretion of the amyloid precursor protein. Is there a feedback effect
of the secreted forms on the secretion?
Compt. rend. Acad. bulg. Sci. 52 (1999) 121-124
(erschienen in Bulgarien, kein Sonderdruck vorhanden)
| |
Kirazov, L.; Schliebs, R.; Bigl, V.
Secretory amyloid precursor protein undergoes membrane-associated proteolysis controlled by extracellular calcium ions.
Compt. rend. Acad. bulg. Sci. 52 (1999) 113-116
(erschienen in Bulgarien, kein Sonderdruck vorhanden)
| |
Lemke, R.; Hartlage-Rübsamen, M.; Schliebs, R.
Differential injury-dependent glial expression of interleukin-1?, ß, and interleukin-6 in rat brain.
Glia 27 (1999) 75-87
| |
Lemke, R.; Rossner, St.; Schliebs, R.Leukemia inhibitory factor
expression is not induced in activated microglia and reactive
astrocytes in response to rat basal forebrain cholinergic lesion.
Neuroscience Letters 267 (1999) 53-56
| |
Mehlhorn, G.; Löffler, Th.; Apelt, J.; Rossner, St.; Urabe, T.; Hattori, N.; Nagamatsu, S.; Bigl, V.; Schliebs, R.
Glucose metabolism in cholinoceptive cortical rat brain regions after basal forebrain cholinergic lesion.
International Journal of Developmental Neuroscience 16 (1998, erschienen 1999) 675-690
| |
Otto, K.; Zimmer, K.; Zeitschel, U.; Hirsch, D.; Reichenbach, A.; Bigl, F.; Bigl, V.:
Transparent three-dimensional microstructures for trapping of living cells
Proc. of SPIE 3605(1999) 241-249
| |
Otto, K.: Zimmer, K.; Zeitschel, U.; Braun, A.; Hirsch, D.; Bigl, F.; Bigl, V.:
Three-dimensional micro-structures for the embedding of living cells
Microelectron eng 46 (1999) 409-412
| |
Otte. K., Zimmer, K.; Zeitschel, U.; Reichenbach, A.; Bigl, F.; Gottschalch, V., Bigl, V.:Trapped
living cells in transparent three-dimensional micro-structures; Proc.
1st Int. euspen Conf. Vol. 2, ed. Pat McKeown, p. (1999) 274-277
| |
Reisner, E.; Nöldner, M.; Rossner, St.; Chatterjee, S. S.; Bigl, V.; Schliebs, R.
Acute effect of KA-672, a putative cognitive enhancer, on neurotransmitter receptor binding in mouse brain.
Neuroscience Letters 274 (1999) 187-190
| |
Rossner, St.; Bakinde, N.; Zeitschel, U.; Schliebs, R., Bigl, V.
Cerebrospinal fluid cholinesterases - markers for loss of cholinergic basal forebrain neurons?
International Journal of Developmental Neuroscience 16 (1999) 669-673
| |
Rossner, St.; Schliebs, R.; Bigl, V.
Régulation du catabolisme de la protéine précurseur de l´amyloide par les mécanismes cholinergiques.
Alzheimer Actualités 143 (1999) 8-13
| |
Rossner, St.; Ueberham, U.; Schliebs, R.; Perez-Polo, J. R.; Bigl, V.Regulated
secretion of amyloid precursor protein by TrkA receptor stimulation in
rat pheochromocytoma-12 cells is mitogen activated protein kinase
sensitive.
Neuroscience Letters 271 (1999) 97-100
| |
Schliebs, R.
Editorial. Basal forebrain cholinergic dysfunction - experimental approaches and the diseased brain.
International Journal of Developmental Neuroscience 16 (1998, erschienen 1999) 591-593
| |
Schwaller, B.; Brückner, G.; Celio, M. R.; Härtig, W.A
polyclonal goat antiserum against the calcium-binding protein
calretinin is a versatile tool for various immunochemical techniques.
Journal of Neuroscience Methods 92 (1999) 137-144
| |
Sorger, D.; Kämpfer, I.; Schliebs, R.; Rossner, St.; Dannenberg, C., Knapp, W. H.
Iodo_QNB cortical binding and brain perfusion: Effects of a cholinergic basal forebrain lesion in the rat.
Nuclear Medicine & Biology 26 (1999) 9-16
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Stahl, T.; Goldammer, A.; Luschekina, E.; Beck, M.; Schliebs, R.; Bigl, V.Long-term
basal forebrain cholinergic-rich grafts derived from trisomy 16 mice do
not develop ß-amyloid pathology and neurodegeneration but demonstrate
neuroinflammatory responses.
International Journal of Developmental Neuroscience 16 (1998,
erschienen 1999) 763-775
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Thal, D. R.; Härtig, W.; Schober, R.
Diffuse plaques in the molecular layer show intracellular Aß8-17-immunoreactive deposits in subpial astrocytes.
Clinical Neuropathology 18 (1999) 226-231
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Ziegert, M.; Witkin, S. S.; Sziller, I.; Alexander, H.; Brylla, E.; Härtig, W.
Heat shock proteins and heat shock protein-antibody complexes in placental tissues.
Infectious Diseases in Obstetrics and Gynecology 7 (1999) 180-185
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1998
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Bigl, V.; Schliebs, R.Simulation of cortical cholinergic
deficits - a novel experimental approach to study pathogenetic aspects
of Alzheimer's disease.
Journal of Neural Transmission, Suppl. 54, Alzheimer's Disease - From
Basic Research to Clinical Applications, Eds. H.-J. Gertz; Th. Arendt,
Wien, New York (1998) 237-247
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Brauer, K.; Seeger, G.; Härtig, W.; Rossner, St.; Poethke, R.; Kacza, J.; Schliebs, R.; Brückner, G.; Bigl, V.Electron
microscopic evidence for a cholinergic innervation of GABAergic
parvalbumin-immunoreactive neurons in the rat medial septum.
Journal of Neuroscience Research 54 (1998) 248-253
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Brückner, G.; Härtig, W.; Seeger, J.; Rübsamen, R.; Reimer, K.; Brauer, K.Cortical
perineuronal nets in the gray short-tailed opossum (Monodelphis
domestica): a distribution pattern contrasting with that shown in
placental mammals.
Anatomy and Embryology 197 (1998) 249-262
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Brückner, G.; Bringmann, A.; Härtig, W.; Köppe, G.; Delpech, B.; Brauer, K.Acute
and long-lasting changes in extracellular-matrix chondroitin-sulphate
proteoglycans induced by injection of chondroitinase ABC in the adult
rat brain.
Experimental Brain Research 121 (1998) 300-310
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Colombo, J.A.; Härtig, W.; Lipina, S.; Bons, N.
Astroglial interlaminar processes in the cerebral cortex of prosimians and Old World monkeys.
Anatomy and Embryology 197 (1998) 369-376
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Engel, F.; Blatz, R.; Schliebs, R.; Palmer, M.; Bhakdi, S.Bacterial
cytolysin perturbs round window membrane permeability barrier in vivo:
possible cause of sensorineural hearing loss in acute Otitis media.
Infection and Immunity 66 (1998) 343-346
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Härtig, W.; Seeger, J.; Naumann, Th.; Brauer, K.; Brückner, G.
Selective in vivo fluorescence labelling of cholinergic neurons containing p75NTR in the rat basal forebrain.
Brain Res. 808 (1998) 155-165
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Hobohm, C.; Härtig, W.; Brauer, K.; Brückner, G.
Low expression of extracellular matrix components in rat brain stem regions containing modulatory aminergic neurons.
Journal of Chemical Neuroanatomy 15 (1998) 135-142
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Lemke, R.; Härtig, W.; Rossner, S.; Bigl, V., Schliebs, R.Interleukin-6
is not expressed in activated microglia and in reactive astrocytes in
response to lesion of rat basal forebrain cholinergic system as
demonstrated by combined in situ hybridization and immunocytochemistry.
Journal of Neuroscience Research 51 (1998) 223-236
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Nitsch, R.M., Rossner, S., Albrecht, C., Mayhaus, M., Enderich, J., Schliebs, R., Wegner, M. Arendt, Th. and von der Kammer, H.
Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promotor.
J. Physiol. Paris 92 (1998) 257-264
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Mehlhorn, G., Löffler, T., Apelt, J., Roßner, S., Urabe, T., Hattori, N., Nagamatsu, S.,
Bigl, V., Schliebs R.
Glucose metabolism in cholinoceptive cortical rat brain regions after basal forebrain cholinergic lesion.
Int. J. Devl. Neurosci. 16:675-690, 1998.
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Riedel, A.; Härtig, W.; Fritschy, J.-M.; Brückner, G.; Seifert, U.; Brauer, K.Comparison
of the rat dorsal and ventral striato-pallidal system: A study using
the GABAA-receptor "1-subunit and aparvalbumin immunolabeling.
Experimental Brain Research 121 (1998) 215-221
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Rossner, St.; Bakinde,N.; Zeitschel, U.; Schliebs, R.; Bigl, V.:
Cerebrospinal fluid cholinesterases -Markers for loss of cholinergic basal forebrain neurons?
Int J Dev Neurosci 16(1998)669-673
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Rossner, S.; Ueberham, U.; Schliebs, R.; Perez-Polo, J.R.; Bigl, V.Neurotrophin
binding to the p75 neurotrophin receptor is necessary but not
sufficient to mediate NGF-effects on APP secretion in PC-12 cells.
Journal of Neural Transmission, Suppl. 54, Alzheimer's Disease - From
Basic Research to Clinical Applications, Eds. H.-J. Gertz; Th. Arendt,
Wien, New York (1998) 279-285
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Rossner, S.; Ueberham, U.; Schliebs, R.; Perez-Polo, J.R.; Bigl, V.
The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling.
Progress in Neurobiology 56 (1998) 541-569
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Rossner, S.; Ueberham, U.; Schliebs, R.; Perez-Polo, J.R.; Bigl, V.p75
and TrkA receptor signaling independently regulate amyloid precursor
protein mRNA expression, isoform composition, and protein secretion in
PC12 cells.
Journal of Neurochemistry 71 (1998) 757-766
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Seifert, U.; Härtig, W.; Brückner, G.; Riedel, A.; Brauer, K.Axonal
expression sites of tyrosine hydroxylase, calretinin- and
calbindin-immunoreactivity in striato-pallidal and septal nuclei of the
rat brain: a double-immunolabelling study.
Brain Research 795 (1998) 227-246
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Thal, D.R.; Härtig, W.; Schober, R.
Stage-correlated distribution of type 1 and 2 dystrophic neurites in cortical and hippocampal plaques in Alzheimer's disease.
Journal of Brain Research 39 (1998) 175-181
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Tremere, L.; Brückner, G.; Brauer, K.; Douglas, D.R., Poethke, R.; Härtig, W.
Co-expression of p75NTR- and calbindin-immunoreactivity in cholinergic neurons of the raccoon basal forebrain.
Brain Research 797 (1998) 351-356
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Wouterlood, F.G.; Van Denderen, J.C.M.; Blijleven, N.; Van Minnen, J.; Härtig, W.Two-laser
dual-immunofluorescence confocal laser scanning microscopy using Cy2-
and Cy5-conjugated secondary antibodies: unequivocal detection of
co-localization of neuronal markers.
Brain Research Protocols 2 (1998) 149-159
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Patent
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Zimmer, K.; Otte, K.; Zeitschel, U.: Hirsch, D.; Braun, A.; Bigl, V.; Bigl, F.:
"Verfahren und Anordnung zur Beweglichkeitseinschränkung von lebenden Zellen"
DE 198 41 125.1, 9.9.1998
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