Publikationen

Briel,D.; Rybak,A.; Kronbach,C.; Unverferth.K.
Substituted 2-Aminothiophen-derivatives: A potential new class of GluR6-Antagonists
Eur. J. Med. Chem. 2009 in press (doi: 10.1016/j.ejmech.2009.09.025)

Briel,D.; Rybak,A.; Mann,S.; Kronbach,C.; Unverferth,K.
Synthesis of Thieno[2,3-d]oxazines and Thieno[2,3-d]thiazines as Subtype Specific Kainate Receptor Antagonists
Curr.Med. Chem. 2009 in press (0929-8673/09)

Briel,D.; Askar,G.B; Ortwein,J.; Unverferth,K.
A convenient synthesis of furans using bromacetylpyran-2-one
Pharmazie 64 (2009) 477

Briel,D.; Rybak,A; Kronbach,C.; Unverferth.K.
Thieno[2,3-d]pyrimidines as Antagonists of the Glutamate Receptors
Pharmazie 63 (2008) 823

Rybak,A.; Kronbach,C.; Unverferth,K.; Briel,D.
Thieno[2,3-d]pyrimidines as Abtagonists of the Glutamate Receptors
Pharmazie, 63 (2008) 823

Drescher,S.; Ramsbeck,D.; Briel,D.; Dobner,B.
Selective Nucleophilic Substitution Reactions in 2,4,6-Trisulfanylsubstituted Pyrimidin-5-carbonitriles by Secondary Amines
J. Heterocyclic Chem. 44 (2007) 757

Briel,D.; Drescher,S.; Dobner,B.
Selective Nucleophilic Replacement of the Benzylsulfanyl Group in 2,4-Disulfanyl-substituted Thieno[2,3-d]pyrimidin-6-carboxylic Acid Derivatives by Sec. Amines
J. Heterocyclic Chem. 42 (2005) 841

Briel,D.; Aurich,R.; Egerland,U.; Unverferth,K.
Synthesis of Substituted 6-Phenylpyrazolo[3,4-d]pyrimidines with Potential Adenosin-A2A Antagonistic Activity
Pharmazie 60 (2005) 732

Briel,D.
Synthesis and Conversion of 3-(2-Hydroxythiobenzamido)benzo[b]furans
Heterocycles 65 (2005) 1295

Briel,D.
Synthesis of Thieno[2,3-d]pyrimidines from 6-Imino-6H-1,3-thiazine Hydroperchlorates
Pharmazie 60 (2005) 75

Briel,D.; Drößler,K.; Rybak,A.; Holzer,M.; Dobner,B.
Protected Mercaptoalkyl-pyrimidinones: Synthesis and Test for Immunostimulating Activity
Pharmazie 60 (2005) 415

K. Daub, B. Habermann, T. Hahn, L. Teich, K. Eger
Synthesis of 3-Aryloxy-2-iodoemodines by Oxidation of Emodin with (Diacetoxyiodo)arenes
Eur. J. Organic Chemistry 2004, 4, 894 - 898

Briel,D.
A New Synthesis of Thiazole Derivatives via Ring Transformation of 6-Imino-6H-1, 3-thiazine Hydroperchlorate
Heterocycles 63 (2004) 2319

Briel,D.
Ring Transformation Reactions Starting from 6-Imino-6H-1,3-thiazines
Heterocycles 60 (2003) 2273

Briel,D.
A New Synthesis of Pyrido[1,2-a]thieno[3,2-d]pyrimidines
Pharmazie 58 (2003) 836

Briel,D.; Holzer,M.; Leistner,S.; Drößler,K.; Dobner,B.
Synthesis of Methylsulfanylpyrimidines with Immunomodulatory Activity
Pharmazie 58 (2003) 759

Briel,D.; Holzer,M.; Leistner,S.; Drößler,K.; Dobner,B.
Synthesis of Methylsulfanylpyrimidines with Immunomodulatory Activity
Pharmazie 58 (2003) 759

S. Kaap, l. Quentin, D. Tamiru, M. Shaheen, K. Eger, H. J. Steinfelder
Structure activity analysis of the pro-apoptotic, anti-tumour effect of nitrostyrene adducts and related compounds
Biochem. Pharmacol. 2002, 65, 603 - 610

B. Habermann, M. Schmidt, K. Eger
Zink-Supplemente besser vor oder während der Mahlzeiten? Messungen der Komplexstabilitäten im System Zinkhistidin-Phytinsäure
Deutsche Lebensmittel-Rundschau 2002, 98, 295 - 99

K. Dannat, J. Tillner, T. Winckler, M. Weiss, K. Eger, T. Dingermann
Effects of medicinal compounds on the differentiation of the eukaryotic microorganism Dictyostelium discoideum: Can this model be used as a screening test for reproductive toxicity in humans?
Pharmazie 2003, 58, 204 - 210

W. Figg, K. Eger, U. Teubert, M. Weiss, M. Gütschow, Th. Hecker, S. Hauschildt
Preparation of thalidomide metabolite analogs as potential angiogenesis inhibitors
PCT Int. Appl. Pat.-Nr. W020020668414 (06.09.2002) Appl.-Nr. WO 2002-US 5868

Briel,D.; Franz,T.; Dobner,B.
Synthesis and Reactions of 6-Methylsulfanyl-2,4-dithioxo-1,2,3,4-tetrahydropyri-midin-5- carbonitrile
J. Heterocyclic Chem. 39 (2002) 863

M. Gütschow, S. Hauschildt, S. Benard, S. Reichl, U. G. Witt, K. Eger, J. Arnhold
Michael adducts of palmitoyiascorbic acid: Effects on the oxidative burst of neutrophils and the production of TNF-alpha in monocytes
Pharmacology, 2002, 66, 162-168

S. Hess, U. Teubert, J. Ortwein, K. Eger
Profiling indomethacin impurities using high-performance liquid chromatography and nuclear magnetic resonance
Europ. J. Pharm. Sei., 2001, 301 - 311

D. Eschke, P. Scheibler, S. Hess, A. Brand, K. Eger, C. Allgaier, K. Nieber
Effects of a novel adenosine A1 receptor ligand on hypoxia induced changes of membrane properties and neurotransmitter releae in rat brain
Neurochem. Int. 2001, 391 -398

S. Hess, M. Dölker, D. Haferburg, H. P. Kertscher, F.-M. Matysik, J. Ortwein, U. Teubert, W. Zimmermann, K. Eger
Separation, analyses and syntheses of trimethoprim impurities
Pharmazie 2001, 306 - 310

M. Gütschow, T. Hecker, A. Thiele, S. Hauschildt, K. Eger
Aza Analogues of Thalidomide: Synthesis and Evaluation as Inhibitors of Tumor Necrosis Factor-a Production In Vitro
Bioorg. Med Chem. 2000,1059 -1065

A. Thiele, M. Thormann, H.-J. Hofmann, W. W. Naumann, K. Eger, S. Hauschildt
A possible role of N-cadherin in thalidomide teratogenicity
Life Sciences 2000, 67,457 - 461

Briel,D.; Pohlers,D.; Uhlig,M.; Vieweg,S.; Scholz,G.; Thormann,M.; Hofmann,H,J.
3-Amino-5-phenoxythiophenes - A Novel Class of Inhibitors of the Cellular L-T3 Uptake
J. Med. Chem. 42 (1999) 1849

Briel,D.
Intramolekulare ANRORC-Reaktion ausgehend von Pyrano[4,3-d]pyrimidinen - eine neue Methode zur Synthese von Thieno[2,3-d]pyrimdinen
Pharmazie 54 (1999) 858

H.-P. Kertscher, A. Habermann, R. Pohle, H. Tauchert, L. Hennig, K. Eger
Zur Darstellung und Charakterisierung von 4-Epidoxycyclin
Sei. Pharm. 66, 287-296 (1998)

S. Hess, C. E. Müller, W. Frobenius, U. Reith, K.-N. Klotz, K. Eger
7-Deazaadenines Bearing Polar Substituents: Structure-Activity Relationships of new Ai- and As-Adenosine Receptor Antagonists
J. Med. Chem. 2000, 43,4636 - 4646

M. Gütschow, T. Hecker, K. Eger
A New One-Pot-Synthesis of 5,5-Disubstituted Hydantoins from Diethylacetamido-malonates and Ureas
Synthesis 1999, 410-414

W. Weber, J. Jäger, M. Dölker, K. Eger
First synthesis of the main metabolite of secobarbital
Pharmazie 53, 771 - 776 (1998)