Universität Leipzig Medizinische Fakultät

Diese Liste führt nur eine Auswahl von Arbeiten ab dem Jahr 2000 auf. Sollten Sie an einer kompletten Aufstellung interessiert sein, beachten Sie bitte die Publikationslisten der einzelnen Autoren.

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Reviews zur NMR-Spektroskopie:

• Schiller, J., Müller, M., Fuchs, B., Arnold, K., Huster, D.: ³¹P NMR spectroscopy of phospholipids: From micelles to membranes. Curr. Anal. Chem. 3 (2007) 283-301.
• Schiller, J., Arnold, K.: Application of high resolution ³¹P NMR spectroscopy to the characterisation of the phospholipid composition of tissues and body Fluids – A methodological review. Med. Sci. Monitor 8 (2002) MT205-222.
• Huster, D., Naji, L., Schiller, J., and Arnold, K.: Molecular Dynamics of the biopolymers in articular cartilage studied by magic angle spinning NMR. Appl. Magn. Reson. 27 (2004) 471-487.
• Huster, D., Schiller, J., Arnold, K.: Solid state NMR to study the dynamics of cartilage polymers. Methods Mol. Med. 101 (2004) 303-318.
• Schiller, J., Huster, D., Fuchs, B., Naji, L., Kaufmann, J., Arnold, K.: Evaluation of cartilage composition and degradation by high resolution magic angle spinning nuclear magnetic resonance. Methods Mol. Med. 101 (2004) 267-286.
• Schiller, J., D., Naji, L., Trampel, R., Ngwa, W., Knauss, R., and Arnold, K.: The use of pulsed-field gradient nuclear magnetic resonance to measure the diffusion of ions and polymers in cartilage: Applications in joint diseases. Methods Mol. Med. 101 (2004) 287-302.

Reviews zur MALDI-TOF Massenspektrometrie:

• Fuchs, B., Süß, R., Schiller, J.: An Update of MALDI-TOF Mass Spectrometry in Lipid Research. Progr. Lipid Res., 49 (2010) 450-475
• Fuchs, B., Schiller, J.: Recent developments of useful MALDI matrices for the mass spectrometric characterization of apolar compounds. Curr. Org. Chem., 13 (2009) 1664-1681.
• Fuchs, B., Nimptsch, A., Süß, R., Schiller, J.: Capabilities and drawbacks of phospholipid analysis by MALDI-TOF mass spectrometry. Methods Mol. Biol., 579 (2009) 103-125.
• Fuchs, B., Süß, R., Nimptsch, A., Schiller, J.: Matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) directly combined with thin-layer chromatography (TLC) - A review of the current state. CHROMATOGRAPHIA, 69 (2009) 95-105.
• Fuchs, B., Schiller, J.: Application of MALDI-TOF mass spectrometry in lipidomics. Eur. J. Lipid Sci. Technol., 111 (2009) 83-98.
• Fuchs, B., Süß, R., Nimptsch, A., Schiller, J.: MALDI-TOF MS: Mehr als Proteinanalytik! BIOforum 5 (2008) 33-35.
• Fuchs, B., Schiller, J.: MALDI-TOF MS analysis of lipids of cells and body fluids. Subcellular Biochemistry (Lipids in Health and Disease), Quinn, P.J. and Wang, X., Eds). Volume 48, 2008, pp. 541-565.
• Fuchs, B., Arnold, K., Schiller, J.: Mass spectrometry of biological molecules. In: Encyclo­pedia of Analyti­cal Chemistry (ed. by Meyers, R.A.), John Wiley & Sons Ltd., Chiches­ter, 2008, pp. 1-39.
• Schiller, J.: MALDI-MS of Lipids. In: MALDI MS: A Practical Guide to Instrumentation, Methods and Applications (Hillenkamp, F. and  Peter-Katalinić, J., eds.), Wiley-VCH, 2007, Weinheim, pp. 215-243.
• Schiller, J., Süß, R., Fuchs, B., Müller, M., Zschörnig, O., Arnold, K.: MALDI-TOF MS in lipidomics. Front. Biosci. 12 (20007) 2568-2579.
• Schiller, J., Süß, R., Fuchs, B., Müller, Zschörnig, O., Arnold, K.: Recent Applications of MALDI-TOF mass spectrometry and ³¹P NMR spectroscopy in lipid and phospholipid research. Future Lipidology 1 (2006) 115-125.
• Schiller, J., Süß, R., Arnhold, J., Fuchs, B., Leßig, J., Müller, M., Petković, M., Zschörnig, O., Arnold, K.: Matrix-assisted laser desorption and ionization time-of-flight (MALDI-TOF) mass spectrometry in lipid and phospholipid research. Progr. Lipid Res. 43 (2004) 443-478.
• Schiller, J., Arnold, K.: Mass spectrometry in structural biology. In: Encyclopedia of Analytical Chemistry (ed. by Meyers, R.A.), John Wiley & Sons Ltd., Chichester, 2000, 559-585.

MALDI-TOF Massenspektrometrie - Methodisches:

• Teuber, K., Riemer, T., Schiller, J.: Is there a specific binding of (phospho)lipids to silica gel? A thin layer chromatographic, MALDI-TOF mass spectrometric and ³¹P NMR spectroscopic study. Anal. Bioanal. Chem., in press.
• Teuber, K., Schiller, J., Fuchs, B., Karas, M., Jaskolla, T.: Significant Sensitivity Improvements by Matrix Optimization: A MALDI-TOF Mass Spectrometric Study of Lipids from Hen Egg Yolk. Chem. Phys. Lipids, 163 (2010) 552–560.
• Fuchs, B., Bischoff, A., Süß, R., Teuber, K., Schürenberg, M., Suckau, D., Schiller, J.: Phosphatidylcholines and -ethanolamines can be easily mistaken in phospholipid mixtures: A negative ion MALDI-TOF MS study with 9-aminoacridine as matrix and egg yolk as selected example. Anal. Bioanal. Chem., 395 (2009) 2479-2487.
• Vujačić, A., Bugarčić, Z.D., Schiller, J., Vasić, V., Petković, M. Matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry of Pt(II) and Pd(II) complexes. Polyhedron, 28 (2009) 2905-2912.
• Petković, M., Vujačić, A., Schiller, J., Bugarčić, Z., Savić, J., Vasić, V.: Application of Flavonoids ‑ Quercetin and Rutin ‑ as a new Matrices for Matrix Assisted Laser Desorption / Ionisation Time-of-Flight Mass Spectrometric Analysis of Pt(II) and Pd(II) complexes. Rapid Commun Mass Spectrom., 23 (2009) 1467-1475.
• Jaskolla, T., Fuchs, B., Karas, M., Schiller, J.: The new Matrix 4-Chloro-α-Cyanocinnamic Acid allows the Detection of Phosphatidylethanolamine Chloramines by MALDI-TOF Mass Spectrometry. J. Am. Soc. Mass Spectrom., 20 (2009) 867-874.
• Petković, M., Schiller, J., Müller, M., Süß, R., Arnold, K., Arnhold, J.: Detection of adducts with matrix clusters in the positive and negative ion mode MALDI-TOF mass spectra of phospholipids. Z. Natforsch., 64B (2009) 35-42.
• Richter, G., Schober, C., Süß, R., Fuchs, B., Birkemeyer, C., Schiller, J.: Comparison of the positive and negative ion electrospray ionization and matrix–assisted laser desorption ionization-time-of-flight mass spectra of the reaction products of phosphatidylethanolamines and hypochlorous acid. Anal. Biochem., 376 (2008) 157-159.
• Fuchs, B., Cross, M.A., Schiller, J.: Changes in phospholipid composition of haemopoietic stem cells during apoptosis monitored by ³¹P NMR spectroscopy and MALDI-TOF mass spectrometry. Chem. Phys. Lipids, 150 (2007) 229-238.
• Fuchs, B., Schober, C., Richter, G., Süß, R., Schiller, J.: MALDI-TOF MS of phosphatidyl-ethanolamines: Different ddducts cause different PSD fragment ion spectra. J. Biochem. Biophys. Meth. 70 (2007) 689-692.
• Schiller, J., Süß, R., Fuchs, B., Müller, M., Petković, M., Zschörnig, O., Waschipky, H.: The suitability of different DHB isomers as matrices for the MALDI-TOF MS analysis of phospholipids: Which isomer for what purpose? Eur. Biophys. J. 36 (2007) 517-527.
• Schiller, J., Süß, R., Petković, M., Hilbert, N., Müller, M., Zschörnig, O., Arn¬hold, J., Arnold, K.: CsCl as an auxiliary reagent for the analysis of phospholipid mixtures by matrix assisted laser desorption and ionization time of flight mass spectrometry (MALDI TOF MS). Chem. Phys. Lipids 113 (2001) 123-131.
• Schiller, J., Süß, R., Petković, M., Zschörnig, O., and Arnold, K.: Negative ion MALDI-TOF mass spectra of complex phospholipid mixtures in the presence of phosphatidylcholine (PC): A cautionary note on peak assignment. Anal. Biochem. 309 (2002) 311-314.

MALDI/TLC-Kopplung:

• Nimptsch, K., Süß, R., Riemer, T., Nimptsch, A., Schnabelrauch, M., Schiller, J.: Differently complex oligosaccharides can be easily identified by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry directly from a standard thin-layer chromatography plate J. Chromatogr. A., 1217 (2010) 3711-3715.
• Fuchs, B., Schiller, J., Süß, R., Nimptsch, A., Schürenberg, M., Suckau, D.: Capabilities and disadvantages of combined matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and high-performance thin-layer chromatography (HPTLC): Analysis of egg yolk lipids J. Planar Chromatogr., 22 (2009) 35-42.
• Fuchs, B., Nimptsch, A., Süß, R., Schiller, J.: The Analysis of Brain Lipids by a directly coupled MALDI/TLC Approach. J. AOAC Int. 91 (2008) 1227-1236.
• Fuchs, B., Schiller, J., Süß, R., Zscharnack, M., Bader, A., Müller, P., Schürenberg, M., Becker, M., Suckau, D.: Analysis of Stem Cell Lipids by Offline HPTLC-MALDI-TOF MS. Anal. Bioanal. Chem. 392 (2008) 849-860.
• Fuchs, B., Schiller, J., Süß, R., Schürenberg, M., Suckau, D.: A direct and simple coupling method between matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) and thin-layer chromatography (TLC). Anal. Bioanal. Chem., 389 (2007) 827-834.
• Sommerer, D., Süß, R., Hammerschmidt, S., Wirtz, H., Arnold, K., Schiller, J.: Analysis of the phospholipid composition of bronchoalveolar lavage (BAL) fluid from man and minipig by MALDI-TOF mass spectrometry in combination with TLC. J. Pharm. Biomed. Anal. 35 (2004) 199-206.
• Schiller, J., Süß, R., Fuchs, B., Müller, M., Zschörnig, O., Arnold, K.: Combined application of TLC and matrix-assisted laser desorption and ionisation time-of-flight mass spectrometry (MALDI-TOF MS) to phospholipid analysis of brain. Chromatographia 57 (2003) S297-S302.

MALDI an Zell- und Gewebeextrakten:

• Dannenberger, D., Süß, R., Teuber, K., Fuchs, B., Nuernberg, K., Schiller, J.: The intact muscle lipid composition of bulls: An investigation by MALDI-TOF MS and ³¹P NMR. Chem. Phys. Lipids, 163 (2010) 157-164.
• Jakop, U., Fuchs, B., Süß, R., Wibbelt, G., Braun, B., Müller, K., Schiller, J.: The solubilisation of boar sperm membranes by different detergents ‑ a microscopic, MALDI TOF MS, ³¹P NMR and PAGE study on membrane lysis, extraction efficiency, lipid and protein composition. Lipids Health Dis., 8 (2009) 49.
• Fuchs, B., Bondzio, A., Wagner, U., Schiller, J.: Phospholipid compositions of sera and synovial fluids from dog, human and horse: a comparison by ³¹P-NMR and MALDI-TOF MS. J. Anim. Physiol. Anim. Nutr., 93 (2009) 410-422.
• Fuchs, B., Jacop, U., Göritz, F., Hermes, R., Hildebrandt, T., Schiller, J. Müller, K.: MALDI-TOF "fingerprint" phospholipid mass spectra allow the differentiation between Ruminantia and Feloideae spermatozoa. Theriogenology, 71 (2009) 568-575.
• Vieler, A., Wilhelm, C., Goss, R., Süß, R., Schiller, J.: The lipid composition of the unicellular green alga Chlamydomonas reinhardtii and the diatom Cyclotella meneghiniana investigated by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) in combination with thin-layer chromatography (TLC). Chem. Phys. Lipids, in press.
• Zschörnig, O., Richter, V., Rassoul, F., Süß, R., Arnold, K., Schiller, J.: Analysis of human blood plasma by MALDI-TOF MS - Evaluation of critical parameters. Anal. Lett. 39 (2006) 1101-1113.
• Fuchs, B., Schiller, J., Wagner, U., Häntzschel, H., Arnold, K.: The phosphatidyl-choline/lysophosphatidylcholine ratio in human plasma is an indicator of the severity of rheumatoid arthritis: Investigations by ³¹P NMR and MALDI-TOF MS. Clin. Biochem. 38 (2005) 925-933.
• Schiller, J., Müller, K., Süß, R., Arnhold, J., Gey, C., Herrmann, A., Leßig, J., Arnold, K., Müller, P.: Analysis of the lipid composition of bull spermatozoa by MALDI-TOF mass spectrometry – A cautionary note. Chem. Phys. Lipids 126 (2003) 85-94.
• Schiller, J., Hammerschmidt, S., Wirtz, H., Arnhold, J., Arnold, K.: Lipid analysis of bronchoalveolar lavage fluid (BAL) by MALDI-TOF mass spectrometry and 31P NMR spectroscopy. Chem. Phys. Lipids 112 (2001) 67-79.       
• Schiller, J., Zschörnig, O., Petković, M., Müller, M., Arnhold, J., Arnold, K.: Lipid analysis of human HDL and LDL by MALDI-TOF mass spectrometry and ³¹P NMR. J. Lipid Res. 42 (2001) 1501-1508.
• Schiller, J., Arnhold, J., Glander, H.-J., Arnold, K.: Lipid analysis of human spermatozoa and seminal plasma by MALDI-TOF mass spectrometry and NMR spectroscopy. Chem. Phys. Lipids 106 (2000) 145-156.

Oxidationsprozesse von Lipiden:

• Schober, C., Schiller, J., Hengstler, J.G., Fuchs, B.: Lysophosphatidylethanolamine is - in contrast to -choline - generated under in vivo conditions exclusively by phospholipase A₂ but not by hypochlorous acid. Bioorg. Chem., 37 (2009) 202-210.
• Bauer, A., Schumann, A., Gilbert, M., Wilhelm, C., Hengstler, J.G., Schiller, J., Fuchs, B.: Evaluation of carbon tetrachloride-induced oxidative stress on rat hepatocytes by ³¹P NMR and MALDI-TOF mass spectrometry: Lysophosphatidylcholine generation from unsaturated phosphatidylcholines. Chem. Phys. Lipids 159 (2009) 21-29.
• Fuchs, B., Schiller, J.: Lysophospholipids: Their generation, physiological role and detection. Are they important disease markers? Mini-Rev. Med. Chem., 9 (2009) 368-378.
• Fuchs, B., Schober, C., Richter, G., Nimptsch, A., Süß, R., Schiller, J.: The Reactions between HOCl and differently saturated Phospholipids: Physiological Relevance, Products and Methods of Evaluation. Mini-Rev. Org. Chem. 5 (2008) 254-261.
• Richter, G., Schober, C., Süß, R., Fuchs, B., Müller, M., Schiller, J.: The reaction between phosphatidylethanolamines and HOCl investigated by TLC: Fading of the dye primuline is induced by dichloramines. J. Chromatogr. B, 867 (2008) 233-237.
• Fuchs, B., Müller, K., Göritz, F., Blottner, S., Schiller, J.: Characteristic oxidation products of choline plasmalogens are detectable in cattle and roe deer spermatozoa by MALDI-TOF mass spectrometry. Lipids, 42 (2007) 991-998.
• Leßig, J., Schiller, J., Arnhold, J., Fuchs, B.: Hypochlorous acid-mediated generation of glycerophosphocholine from unsaturated plasmalogen glycerophosphocholine lipids. J. Lipid Res. 48 (2007) 1316-1324.
• Fitzl, M., Süß, R., Arnold, K., Schiller, J.: Nitrite reduces the effects of HOCl on unsaturated phosphatidylcholines - A MALDI-TOF MS study. Chem. Phys. Lipids 140 (2006) 11-17.
• Zschörnig, O., Bergmeier, C., Süß, R., Arnold, K., Schiller, J.: Human low-density lipoprotein oxidation: Hypochlorous acid leads to the generation of lysophospholipids under acidic conditions. Lett. Org. Chem. 1 (2004) 381-390.
• Schiller, J., Süß, R., Petković, M., Arnold, K.: Thermal stressing of unsaturated vegetable oils: Effects analysed by MALDI-TOF mass spectrometry, ¹H and ³¹P NMR spectroscopy. Eur. Food Res. Technol. 215 (2002) 282-286.
• Arnhold, J., Osipov, A.N., Spalteholz, H., Panasenko, O.M., Schiller, J.: Formation of lyso-phospholipids from unsaturated phosphatidylcholines under the influence of hypochlorous acid. Biochim. Biophys. Acta 1572 (2002) 91-100.
• Schiller, J., Süß, R., Petković, M., Hanke, G., Vogel, A., Arnold, K.: Effects of thermal stressing on saturated vegetable oils and isolated triacylglycerols - Product analysis by MALDI-TOF mass spectrometry, NMR and IR spectroscopy. Eur. J. Lipid Sci. Technol. 104 (2002) 496-505.
• Arnhold, J., Osipov, A.N., Spalteholz, H., Panasenko, O.M., Schiller, J.: Effects of hypochlorous acid on unsaturated phosphatidylcholines. Free Radic. Biol. Med. 31 (2001) 1111-1119.

Glykosaminoglykane, Knorpel und reaktive Sauerstoffverbindungen:

• Becher, J., Möller, S., Weiss, D., Schiller, J., Schnabelrauch, M.: Synthesis of new regioselectively sulfated hyaluronans for biomedical application. Macromolecular Symposia, in press.
• Galle, J., Bader, A., Grill, W., Fuchs, B., Käs, J.A., Krinner, A., Müller, K., Schiller, J., Schulz, R., von Butlar, M., Löffler, M.: Stem cells in cartilage repair: State of the art and methods to monitor cell growth, differentiation and cartilage regeneration. Curr. Medic. Chem., 17 (2010), 2274-2291.
• Volpi, N., Schiller, J., Stern, R., Šoltés, L.: Role, metabolism, chemical modifications and applications of hyaluronan. Curr. Medic. Chem., 16 (2009) 1718-1745.
• Nimptsch, A., Schibur, S., Schnabelrauch, A., Fuchs, B., Huster, D., Schiller, J.: Characterization of the quantitative relationship between signal-to-noise (S/N) ratio and sample amount on-target by MALDI-TOF MS: Determination of chondroitin sulfate subsequent to enzymatic digestion. Anal. Chim. Acta, 635 (2009) 175-182.
• Kogan G., Šoltés L., Stern R., Schiller J., Mendichi R.  Hyaluronic acid: Its function and degradation in in vivo systems. In: Atta-ur-Rahman (ed.): Studies in Natural Products Chemistry (Vol. 34 Bioactive Natural Products, Part D), Elsevier, Amsterdam 2008, pp. 789-882.
• Šoltés, L., Kogan, G., Stankovská, M., Mendichi, R., Rychlý, R., Schiller, J.,  Gemeiner, P.: Degradation of high-molar-mass hyaluronan and characterization of fragments. Biomacromolecules, 8 (2007) 2697-2705.
• Schulz, R., Höhle, S., Zernia, G., Zscharnack, M., Schiller, J., Bader, A., Arnold, K., Huster, D.: Analysis of extracellular matrix production in artificial cartilage constructs by histology, immuncytochemistry, mass spectrometry, and NMR spectroscopy. J. Nanosci. Nanotechnol. 6 (2006) 2368-2381.
• Busse, K., Averbeck, M., Anderegg, U., Arnold, K., Simon, J.C., Schiller, J.: The signal-to-noise ratio as a measure of HA oligomer concentration: a MALDI-TOF MS study. Carbohydr. Res. 341 (2006) 1065-1070.
• Šoltés, L., Stankovská, M., Brezová, V., Schiller, J., Arnhold, J., Kogan, G., Gemeiner, P.: Hyaluronan degradation by cupric chloride and ascorbate: Rotational viscometric, EPR spin trapping, and MALDI-TOF mass spectrometric investigations. Carbohydr. Res. 341 (2006) 2826–2834.
• Soltes, L., Mendichi, R., Kogan, G., Schiller, J., Stankovska, M., Arnhold, J.: Degradative action of reactive oxygen species on hyaluronan. Biomacromolecules 7 (2006) 659-668.
• Schiller, J., Fuchs, B., Arnhold, J., Arnold, K.: Contribution of reactive oxygen species to cartilage degradation in rheumatic diseases: Molecular pathways, diagnosis and potential therapeutic strategies. Curr.  Medic. Chem. 10 (2003) 2123-2145.
• Hilbert, N., Schiller, J., Arnhold, J., Arnold, K.: Cartilage degradation by stimulated human neutrophils: Elastase is the enzyme most responsible for cartilage breakdown. Bioorg. Chem. 30 (2002) 119-132.
• Schiller, J., Naji, L., Huster, D., Kaufmann, J., Arnold, K.: ¹H and ¹³C HR-MAS NMR investigations on native and enzymatically-digested cartilage. MAGMA 13 (2001) 19-27.
• Schiller, J., Benard, S., Arnhold, J., Reichl, S., Arnold, K.: Cartilage degradation by stimulated human neutrophils: Reactive oxygen species markedly influence the activity of proteolytic enzmyes. Chem. Biol. 7 (2000) 557-568.