Chemical biology and organic chemistry
Modulation of protein-protein interactions with small organic molecules
Protein-protein interactions form the basis of most biological processes, but represent very challenging targets for small organic molecules. The overall aim of our research is to devise innovative methods for the efficient design, development, and identification of small organic modulators of protein-protein interactions. Using an interdisciplinary combination of chemical and biological methods, our recent work has demonstrated that the inhibition of protein-protein interactions actually represents a powerful approach towards expanding the druggable proteome, and towards the selective inhibition of certain protein kinases. Our most recent discovery indicates that the inhibition of protein–protein interactions may be a potential mode of action of some of the existing therapeutic compounds in human use.
Prof. Dr. Thorsten Berg
University of Leipzig
Institute of Organic Chemistry
Tel.: +49 341 9736-527
Fax: +49 341 9736-599