Research Area B: Biological active profiles in cells systems and aECM-backed tissue regeneration

The Research Area B – Biological active profiles in cells systems and aECM-backed tissue regeneration – combine projects with cell biological and clinical orientation. The main focus here is the systematic cell and molecular biological characterisation of matrix/cell interactions in complex systems. We investigate mainly cell types that have intensive matrix contacts in skin and bones.

The following subprojects are part of the Research Area B:

B1 Influence of artificial and native extracellular matrices on adhesion and differentiation of mesenchymal stem cells and osteoblats (Hempel)

B2 Regulation of osteoclast function and osteoclast signalling by extracellular matrix components (Hofbauer)

B3 Immune responses to native and artificial extracellular matrices (Simon)

B4 Impact of artificial extracellular matrix on fibroblast functions (Anderegg)

B5 In vivo- and ex vivo-investigation of the effects of artificial matrices on implant surfaces in long bones (Rammelt/Zwipp)

B6 Analysis of newly designed surface coatings: a maxillofacial animal model (Mai/Eckelt)

B8 Three-dimensional analysis of in vivo reactions to artificial extracellular matrices (Scharnweber/Scheler)

B9 Modulation of tissue regeneration by glycosaminoglycan-binding anti-inflammatory Cytokine Interleukin-10 (Roers)