Research Projects
- Autonomic regulatory mechanisms in the respiratory tract of horses
- Cloning and expression of equine β-adrenergic receptors
- Inflammatory mediator-mediated regulation of the autonomic nervous system in pulmonary diseases
- Isolation, characterization & transformation of primary tracheobronchial epithelial cells – alternative models to animal experiments
- Cardiac adrenergic & miscarrying receptors in the pathophysiology of heart diseases (Cooperation with Heart Centre, Leipzig)
- Systemic endocrine effects of topical glucocorticoid formulations
- Species variability in pharmacokinetics & bioavailability of veterinary drugs
- Characterization of active drug carriers, with emphasis on rat methotrexate-carrier and its splicing variants
- Pharmacokinetic drug interactions in liver and kidney (e.g. Regulation of methotrexate carrier by cytochrom-P450 inductors)
- Concentration-dependent bile acid-mediated induction of P-glycoprotein in kidney epithelial cells
- Cell culture models for prediction of target organ toxicity actively transported drugs
- Development of a nation-wide monitoring system of antibiotic consumption in farm animals (VetCAb)
- Cloning of breast cancer resistance protein (BCRP) in the ruminant udder