Brain Dynamics Graduate School is happy to announce a new online talk in our Seminar Series:
- Prof. Dr. Andreas S. Thum
Department of Genetics, Faculty of Life Sciences, University Leipzig
"From structure to function: what we can learn from the connectome of the Drosophila larva"
03rd June 2022, 12:00
Zoom Meeting (https://uni-leipzig.zoom.us/j/66047630272?pwd=TWhrY3N4YkQ2a0FHU3loKzFzblBndz09
Meeting ID: 660 4763 0272
The Drosophila larva is a relatively simple, 10 000-neuron study case for learning and memory with enticing analytical power, combining genetic tractability, the availability of robust behavioral assays, the opportunity for single-cell transgenic manipulation, and an emerging synaptic connectome of its complete central nervous system. Indeed, although the insect mushroom body is a much-studied memory network, the connectome revealed that more than half of the classes of connection within the mushroom body had escaped attention. The connectome also revealed circuitry that integrates, both within and across brain hemispheres, higher-order sensory input, intersecting valence signals, and output neurons that instruct behavior. Further, it was found that activating individual dopaminergic mushroom body input neurons can have a rewarding or a punishing effect on olfactory stimuli associated with it, depending on the relative timing of this activation, and that larvae form molecularly dissociable short-term, long-term, and amnesia-resistant memories. Together, the larval mushroom body is a suitable study case to achieve a nuanced account of molecular function in a behaviorally meaningful memory network.