Joseph Claßen
Pathophysiology of moving slowly in Parkinson’s disease
Brain Dynamics Graduate School invites you to the next talk within our Seminar Series:
- Prof Dr Joseph Claßen
Department of Neurology, University Hospital Leipzig
"Pathophysiology of moving slowly in Parkinson’s disease"
07th February 2025, 12:00
Paul Flechsig Institute - Center of Neuropathology and Brain Research, Room 3093, Liebigstraße 19 (Haus C), 04103 Leipzig
Abstract:
Bradykinesia, a hallmark motor symptom of Parkinson’s disease, is characterized by slowness of movement initiation and execution. Its pathophysiology is primarily linked to dopamine depletion in the substantia nigra pars compacta, leading to dysfunction in the cortico-basal ganglia-thalamo-cortical circuits. The reduced dopaminergic input to the striatum disrupts the balance between the direct and indirect pathways, resulting in abnormal oscillatory activity. Here we discuss recent findings on abnormal subcortical and cortical oscillatory activity contributing to bradykinesia. Understanding these mechanisms is crucial for developing targeted therapeutic strategies.