Modern Diseases  


DFG Projects

Obesity Mechanisms - SFB 1052

There are several questions about the unresolved, pathogenic mechanisms of obesity and its comorbid disorders, three of which are central and unifying to the Collaborative Research Centre: (1) Why are (obese) people in a positive caloric balance? (2) How does overeating lead to adverse fat deposition and adipose tissue inflammation? (3) Which fat derived "signals" (adipokines) are responsible for obesity-related diseases? Consequently, we define three research areas reflecting these major research questions: (1) overeating, (2) fat deposition and inflammation, and (3) adipokines. Read more

Funktionelle Biomaterialien zur Steuerung von Heilungsprozessen in Knochen- und Hautgewebe - vom Material zur Klinik- SFB/TRR 67

The important successes in implantation and transplantation medicine achieved in the last years have their base mainly on expanding of experimental knowledge. [...] Read more

TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules - SFB/TRR 152

Transient receptor potential (TRP) channels represent a diverse protein family with salient roles as versatile cellular sensors and effectors. TRP proteins control an exceptionally broad spectrum of homeostatic physiological functions, illustrated by more than 20 hereditary human diseases caused by mutations in 12 Trp genes. Read more

Clinical Study - A multi-centered, randomized, controlled trial comparing weightloss in endoscopically implanted duodenal-jejunal bypass liner vs intragastic balloons vs a sham procedure

Endoscopic treatment of obesity constitutes a viable and reversible alternative to bariatric surgery if conservative treatment proves ineffective. This clinical study is a multi-centered, randomized controlled patient and assessor blinded efficacy trial with two intervention arms and a sham control arm [...] Read more


EU Projects

Imaging the Force of Cancer (FORCE) - H2020 (RIA)

Cancer is the second leading cause of mortality in EU member states with ~90% of all cancer deaths caused by metastatic spread. Despite its significance, measuring metastatic potential as well as potential indicators of therapy efficacy remain unmet clinical challenges. Recently, it has been demonstrated in vitro, that aggressive metastatic cells pull on their surroundings suggesting that metastatic potential could be gauged by measuring the forces exert by tumours. [...] Read more

Multivessel versus culprit lesion only percutaneous revascularization in patients with acute myocardial infarction complicated by cardiogenic shock - FP7

Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) represents a major European health care concern with mortality rates between 40-70%. Approximately 70-80% of these patients present with multivessel disease defined as coronary lesions in more than one vessel. [...] Read more

Metagenomics in Cardiometabolic Diseases - FP7

METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. [...] Read more

BMBF Projects

Integrated Research and Treatment Center (IFB) AdiposityDiseases

The IFB team researches and treats obesity (adiposity) and its secondary diseases in children, adolescents, and adults. It is a joint center of the University and the University Hospital Leipzig - sponsored by the Federal Ministry of Education and Research. The following subprojects of the IFB belong to the Research Profile Area "Modern Deseases": "Treatment of binge eating disorder (BED) in adolescents", "Longitudinal collection of psychosocial factors in adiposity surgery". Read more

SONORAY - Tumor therapy combined by MR-guided focused ultrasound and radiation therapy

The multidisciplinary project SONORAY combines noninvasive image-guided therapy approaches of focused ultrasound and radiation therapy to improve efficiency of cancer treatment. [...] Read More

NutriCARD - Competence Cluster for Nutrition and Cardiovasciular Health.

NutriCard is an innovative co-operative approach developed by regional universities, and agriculture and food indutries to research ad disseminate important nutritional strategies with which the consumer, by altering dietary choices and lifestyle, can significantly benefit their cardivascular health. [...] Read More

A model of the Intestinal Stem Cell Niche: Development, Regeneration and Aging (INDRA)

The aim of this experimental-theoretical project is to lay foundations for a systematic biological model of the organization of the intestinal epithelium. [...] Read More

CAPSyS - Systems Medicine of Community Acquired Pneumonia

CAPSyS is a consortium with the aim to investigate and better understand the course of pneumonia from infection to resolution. [...] Read More

Defined duration of anucleosids analogues therapy at HBEAG negativ patients with chronical hepatitis B: a randomized study (STOP-NUC)

With around 350 Million chronically contracted people is hepatitis B worldwide the most common viral infection. The therapy of a chronical hepatitis B is difficult, mostly without complete recovery. [...] Read More

SysMedOS - Integration of oxidative stress into systems medicine view for obesity and obesity related complications.

The project aims to include knowledge on different oxidized versions of lipids and proteins into the integrated view on obesity related complicsations by systems medicine. [...] Read More

last update: 02.08.2018 


Prof. Dr. med.
Matthias Blüher

Endocrinology and Nephrology
University Hospital
Liebigstraße 20
04103 Leipzig

Phone: +49 341 97-15984
Fax: +49 341 97-22439

Prof. Dr. Wieland Kiess
Child and Adolescent Medicine
University Hospital
Liebigstr. 20a
04103 Leipzig

Phone: +49 341 97-26000
Fax: +49 341 97-26009

Prof. Dr. Jan Simon
Dermatology, Venereology and Allergology
University Hospital
Philipp-Rosenthal-Straße 25
04103 Leipzig

Phone: +49 341 97-18600
Fax: +49 341 97-18609