Molecular and Cellular Communication  

Molecular and
Cellular
Communication

DFG Projects

Regulation and Manipulation of Information Flow within Dynamic Protein and Lipid Environments - SFB 645

Key objectives of the Collaborative Research Centre are to understand the molecular mechanisms that control the asymmetric distribution of membrane constituents (lipids, proteins), the role of lipid metabolising enzymes in membrane composition and cellular physiology, the impact of specific lipid components on membrane protein function, the role of lipid metabolites in cell signalling and the generation and application of novel tools (e.g. small molecule inhibitors) for the analysis of membrane function. [...] Read more

Elucidation of Adhesion-GPCR signaling - FOR 2149

Adhesion-type G protein-coupled receptors (aGPCR) form a large class of seven-transmembrane spanning (7TM) receptors. 7TM receptors have proven the linchpin for countless physiological functions and a treasure trove for modern pharmaceutical intervention. aGPCR appear in stark contrast to the rest of the 7TM receptor superfamily. Despite their abundance, remarkable size and [...] Read more

Epithelial intercellular junctions as dynamic hubs to integrate forces, signals and cell behaviour - SPP 1782

Epithelia are stable tissues that line organ and body surfaces to provide structural support and serve as barriers against diverse external stressors such as mechanical force, pathogens, toxins, and dehydration. [...] Read more

Chemoselective Reactions for the Synthesis and Application of Functional Proteins - SPP 1623

The Priority Programme focusses on the development of chemical methods for obtaining functional proteins. Thereby, the participating research groups aim to develop new approaches to tackle biological questions by combining chemoselective organic reactions with modern techniques from biochemistry and molecular biology. Within the funded projects of the Priority Programme several scientific aims will be addressed, for instance [...] Read more

EU Projects

BETA3_LVH - Horizon 2020

Patients with cardiovascular risk factors, e.g. hypertension and obesity are at risk of developing heart failure with preserved ejection fraction (HFpEF), a highly prevalent disease in the elderly, mostly women population. [...] Read more

Design of a versatile and fast colloidal sensor based on virus modified particles - FP7

Viroma project aims to fabricate multiplexed bead-based arrays as sensing devices on the basis of virus capsid and virosome Layer by Layer-assisted assembly on colloidal carriers. The virosome based platform technology will be suitable for the detection of several analytes ranging from comparatively small molecules, of the size of dioxins to larger biomolecules such as small proteins. Such systems are [...] Read more

Hybrid Drug Delivery Systems upon Mesoporous Materials, Self Assembled Therapeutics and Virosomes

HYMADE focuses on the development of capsules and engineered colloidal particles for drug delivery combining mesoporous colloids, the Layer by Layer (LbL) technique and virosomes. The capsules and particles have potential applications in cancer and inflammatory diseases such as rheumatoid arthritis and uveitis. [...] Read more

BMBF Projects

The virtual liver

The Virtual Liver Network (VLN) represents a major research investment by the German Government focusing on work at the “bleeding edge” of Systems Biology and Systems Medicine. This Flagship Programme is tackling one of the major challenges in the life sciences: that is, [...] Read more

A Model of the Ageing Epigenome (GERONTOSYS2: MAGE)

MAGE was started in February 2011 as part of the GerontoSys2 initiative of the German Federal Ministery of Education and Research (BMBF). Ageing is characterized by a gradual functional decline of virtually every tissue system and increased vulnerability and susceptibility to numerous diseases. Various experiments demonstrated that [...] Read more

Neue ATA26-Peptidantibiotika: In vivo Eigenschaften,
Charakterisierung der bakteriellen Targets und Aufklärung möglicher Resistenzmechanismen

Project description in german language available on the web page of the BMBF. Read more

Molekulare Mechanismen in Malignen Lymphomen mit MYC-Deregulation

Project description in german language available on the web page of the university of Göttingern. Read more

Microfluidic 3D cell culture model

Project description on in German available. [...] Read more

Fluorszenz-Korrelations-Spektroskopie zur Interaktionsanalyse von Membran Proteinen und deren Liganden - Neue Methoden für das Screening von Rezeptoragonisten und -antagonisten

No project description available.

Anwendung von Ionenstrahlmikroskopie und Konfokaler Ramanmikrospektroskopie zur Detektion und Quantifizierung von Nanopartikeln in Zellen und Geweben (NanoBioDetect)

Project description in german language available on the web page of the project. Read more

Personalisierte Abschätzung von Spätfolgen nach Strahlenexposition und Orientierungshilfe für Strahlenanwendungen in der Medizin

PASSOS analyses the long-term health risks of cancer and circulatory diseases for different medical treatment and diagnostic applications. The risk models that are developed integrate radiobiological knowledge and [...] Read more

System-basierte Prädiktoren für das biologische und klinische Verhalten von Gliomen (SYS-Glio)

Project description in german language available on the web page of the eMED. Read more 

INHALT-90: 90 days inhalation testing with CeO2 in the rat and subsequent analysis of gene expression profiles for the early detection of toxic / carcinogenic effects

In the past ten years, toxicological characterisation and evaluation have been attaching enormous weight and interest to the technically versatile synthetic nanoparticles used in chemistry, medicine, environmental engineering, and energy technology. This development is mainly due to the fact that [...] Read more

Vaspin, KLK7 und die Kommunikation zwischen Fettgewebe und pankreatischen Betazellen

No project description available.


last update: 17.08.2017 

Contact

Prof. Dr.
Annette Beck-Sickinger

Institute of Biochemistry
Brüderstraße 34
04103 Leipzig

Phone: +49 341 97-36901
E-Mail

Prof. Dr.
Torsten Schöneberg

Institute of Biochemistry
Johannisallee 30
04103 Leipzig

Phone: +49 341 97-22150
E-Mail

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