The strategic research field comprises four research profile areas that investigate the foundations of life and health in humans, nature and the environment. Scholars from the life sciences, natural sciences, economics, the humanities, social sciences and computer science work together to advance basic and applied research and its transfer into society.

Modern Diseases

Grafik zum Forschungsprofilbereich „Zivilisationserkrankungen“
Image: Daniel Janetzki, Visionauten

The impact of civilisation on humanity

Modern civilisation can contribute to or even cause functional and organic human diseases. We do not yet fully understand the exact mechanisms behind “modern” diseases associated with civilisation. Investigating them is the central goal of this research profile area.

The participating institutions are from the natural and life sciences as well as the humanities and social sciences. Their joint work has interwoven them into large research alliances.

The research focus is on interactions between inflammation, metabolism and regeneration processes, and their significance for modern, lifestyle-related diseases. While Leipzig University’s particular focus is on investigating the modern epidemic of obesity, the Modern Diseases research profile area also unites a number of cancer research projects.

The researchers develop innovative therapies, individually adapted preventive measures and campaign-based health recommendations. The basis for this is excellent collaborative research in the fields of biomedicine, psychology and sociocultural systems. On the basis of successful externally funded projects in the research profile area, the aim is to establish an international reference centre for integrative obesity research.

Adipositas-Simulation bei der Langen Nacht der Wissenschaften 2018.
Simulating obesity at the Long Night of the Sciences in 2018. Photo: Christian Hüller

CRC 1052: Obesity Mechanisms

The Obesity Mechanisms Collaborative Research Centre has three main foci in its obesity research: overeating, fat deposition and inflammation, and altered adipokine secretion. The aim is to better understand the mechanisms that lead to extreme obesity. Graduates of the Obesity Mechanisms Integrated Research Training Group can acquire the knowledge gained in obesity research as well as additional practical skills, thus equipping them for successful scientific careers.

SFB spokesperson Professor Matthias Blüher measuring abdominal girth at the obesity outpatient clinic. Photo: Christian Hüller

 

TRR 152: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules

The Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules Transregio 152 is researching novel, case-specific treatments for diseases associated with dysfunctional transient receptor potential (TRP) channels, such as chronic pain. To this end, the researchers are working on reclassifying and redefining the known TRP channels.

TRR 67: Functional Biomaterials for Controlling Healing Processes in Bone and Skin – from Material Science to Clinical Application

Transregio 67, Functional Biomaterials for Controlling Healing Processes in Bone and Skin – from Material Science to Clinical Application, is researching the development of novel functional biomaterials to improve bone and skin regeneration in an ageing, multimorbid population.

Clinical Trial: A Multi-Centred, Randomized, Controlled Trial Comparing Weight Loss in Endoscopically Implanted Duodenal-Jejunal Bypass Liner Versus Intragastric Balloons Versus a Sham Procedure

The clinical trial comparing weight loss in endoscopically implanted duodenal-jejunal bypass liners versus intragastric balloons versus a sham procedure compares sham endoscopies with the use of intragastric balloons and duodenal-jejunal bypass liners in the treatment of obesity.

FORCE – Imaging the Force of Cancer

Professor Josef Alfons Käs (Peter Debye Institute for Soft Matter Physics)

CULPRIT-SHOCK – Multivessel Versus Culprit Lesion Only Percutaneous Revascularization in Patients with Acute Myocardial Infarction Complicated by Cardiogenic Shock

Professor Joachim Thiery (Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics)

METACARDIS – Metagenomics in Cardiometabolic Diseases

Professor Michael Stumvoll (Department of Endocrinology and Nephrology)

Federal ministries fund the following projects, which receive funding of 500,000 euros or more.

Integrated Research and Treatment Center (IFB) AdiposityDiseases

Scientific director: Professor Michael Stumvoll (Faculty of Medicine; University Hospital, Department of Endocrinology and Nephrology)

The IFB researches and treats obesity (adiposity) and its accompanying diseases in children, adolescents and adults. It is a joint centre of Leipzig University and the University Hospital Leipzig, and funded by the Federal Ministry of Education and Research (BMBF).

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SONO-RAY – Tumor Therapy Combined by MR-Guided Focused Ultrasound and Radiation Therapy

Project director: Professor Andreas Melzer (Faculty of Medicine; University Hospital, Innovation Center for Computer-Assisted Surgery (ICCAS))

The BMBF-funded SONO-RAY project is establishing an interdisciplinary research programme in Leipzig on focused ultrasound. By combining radiotherapy and focused ultrasound, researchers hope to be able to treat tumour diseases more effectively in the future.

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nutriCARD – Competence Cluster for Nutrition and Cardiovascular Health

Project director: Professor Peggy Braun (Faculty of Veterinary Medicine, Institute of Food Hygiene)

In the nutriCARD competence cluster, around 40 scientists from various disciplines are researching the mechanisms of nutritional and age-related diseases and in turn developing heart-healthy foods. As part of this holistic project, specially developed consumer awareness courses aim at improving the nutritional knowledge and behaviour of the population in the long term.

Further information:

nutriCard website
BMBF project website

 

NWG INDRA: A Model the Intestinal Stem Cell Niche: Development, Regeneration and Ageing

Project director: Dr Jörg Galle (Faculty of Medicine, Interdisciplinary Centre for Bioinformatics)

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e:Med CAPSyS – Modelling of Community-Acquired Pneumonia

Project director: Professor Markus Löffler (Faculty of Medicine, Institute for Medical Informatics, Statistics and Epidemiology)
CAPSyS is an interdisciplinary research network that investigates the causes and progression of severe pneumonia.

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STOP-NUC: Defined Duration of Nucleoside Analogue Therapy in HBeAg-Negative Patients with Chronic Hepatitis B: A Randomised Trial

Project director: Dr Florian van Bömmel (Faculty of Medicine; University Hospital, Department of Gastroenterology and Rheumatology)

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SysMedOs – Integration of Oxidative Stress into Systems Medicine View for Obesity and Obesity-Related Complications

Project director: Dr Maria Fedorova (Faculty of Chemistry and Mineralogy, Institute of Bioanalytical Chemistry)

The BMBF-funded junior research group SysMedOs is investigating the behaviour of differently oxidised versions of lipids and proteins in obesity. The research enables a consideration of metabolically healthy and diseased obesity phenotypes from a systems medicine perspective.

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In the field of gastric cancer research, tissue samples and data on treatment and disease progression are being collected from approximately 500 patients at the Leipzig University Cancer Center, in order to obtain reliable, statistically significant results. The sub-project of the SYS-Stomach Consortium is funded by the BMBF.

Professor Matthias Blüher

Department of Endocrinology and Nephrology

Liebigstraße 20
04103 Leipzig

Phone: +49 341 97-15984
Fax: +49 341 97-22439

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Professor Wieland Kiess

Department of Paediatrics

Liebigstraße 20a
04103 Leipzig

Phone: +49 341 97-26000
Fax: +49 341 97-26009

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Sustainable Systems and Biodiversity

Emblematische Grafik für das Forschungsprofilfeld "Nachhaltige Systeme und Biodiversität"
Image: Daniel Janetzki, Visionauten

Two major challenges of our time, the transformation of energy systems and the sustainable handling of biodiversity as a resource, are the focus of the research activities in this profile area.

The research interests lie in developing environmentally friendly catalytic processes, identifying innovative technologies and solution strategies for energy production, as well as the fundamentals of biodiversity conservation. The aim is to link these three areas of sustainability research:

  1. How can economically efficient energy landscapes be designed to maximise biodiversity and ecosystem services?
  2. How can the use of biomass as a raw material base be optimised by new catalytic processes?
  3. How can new catalytic processes optimise the use of biomass as a raw material base?

The spectrum of approaches ranges from laboratory development and prognosis models to major ecological experiments on the landscape scale.

The German Research Foundation (DFG) supports a large number of projects at our university in cooperation with other scientific institutions. The following are the most important collaborative projects in the field of Sustainable Systems and Biodiversity:

German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig

In collaboration with the Martin Luther University Halle-Wittenberg (MLU), the Friedrich Schiller University Jena (FSU) and Leipzig’s Helmholtz Centre for Environmental Research (UFZ), our university is currently home to the German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig. Since 2012, researchers from more than 30 nations have been investigating the largely damaging influence of human activity on fauna and flora, developing a scientific basis for the sustainable stewardship of our planet’s biodiversity.

TRR 172: Arctic Amplification

With the Transregio 172, we are conducting systematic large-scale research in the field of Arctic climate change (AC)³ for the first time in Germany. Applying a variety of different methods, the aim of the wide-ranging research alliance with the University of Bremen, the University of Cologne, the Alfred Wegener Institute and the Leibniz Institute for Tropospheric Research is to observe climatic changes in the Arctic over long periods of time. On the basis of observations of measuring instruments on satellites, aircraft, airborne balloon platforms and research vessels, but also the results of selected ground-based monitoring stations, the researchers are improving the reliability of models for predicting the warming already recorded in the Arctic.

Arktisexpedition mit einem Forschungsschiff in 2017
Arctic expedition in 2017 with the icebreaker Polarstern. Photo: Dr Marlen Brückner, Institute for Meteorology

 

CRC 762:  Functionality of Oxide Interfaces

The Collaborative Research Centre 762 “Functionality of Oxide Interfaces” focuses on the production and characterisation of oxide heterostructures with different components. Researchers from physics and chemistry are jointly developing these new materials with ferroelectric, magnetic, semiconducting and insulating properties. Established in 2008, the collaborative project with the Martin Luther University Halle-Wittenberg is currently in its third funding period. Professor Marius Grundmann of the Felix Bloch Institute for Solid State Physics is one of the projects’ two vice spokespersons.

RU 1451:  Exploring Mechanisms Underlying the Relationship between Biodiversity and Ecosystem Functioning

Based on the results of a long-term biodiversity experiment in Jena, the project looks at mechanisms which determine the influence of plant diversity on ecosystem processes. Sixty plant species common to Central European Arrhenatherum elatius grasslands have been selected. Professor Nico Eisenhauer from the iDiv research centre is the spokesperson for the Research Unit.

RU 891:  The Role of Tree and Shrub Diversity for Production, Erosion Control, Element Cycling and Species Conservation in Chinese Subtropical Forest Ecosystems

The Chinese-European Research Unit, represented by the Martin Luther University Halle-Wittenberg, has started a new experiment on biodiversity and ecosystem functions in the subtropical forests of China. The aim of this project is to analyse the influence of tree and shrub diversity on ecosystem functions and services. Professor Christian Wirth assists with data management in a sub-project. In his sub-project, Dr Andreas Schuldt examines the role of herbivory in mediating of ecosystem functions in species-rich forests.

PP 1294: Atmospheric and Earth System Research with the “High Altitude and Long Range Research Aircraft” (HALO)

The HALO Infrastructure Priority Programme is coordinated by Professor Manfred Wendisch at the Leipzig Institute for Meteorology. HALO is a research aircraft that supports the project partners in their investigations of atmospheric processes, earth observation and climate research.

Blick über die Wolken vom Forschungsflugzeug HALO
Above the clouds: atmospheric research with the research aircraft HALO. Photo: Manfred Wendisch

The European Research Council (ERC) and European Social Fund (ESF) are currently funding two projects by Leipzig-based scientists working in this research profile area:

ERC Starting Grant: P4SB – From Plastic Waste to Plastic Value using Pseudomonas Putida Synthetic Biology
Director: Professor Nico Eisenhauer (iDiv)

ESF project: S2DES Smart Sensor-Based Ecosystem Services
Director: Professor Rainer Alt (Information Systems Institute)

Professor Nico Eisenhaier (iDiv) at work in the lab.
ERC grant recipient Professor Nico Eisenhauer (iDiv) at work in the laboratory. Photo: Christian Hüller

Ministries such as the Federal Ministry of Education and Research (BMBF) support a number of projects at our university. The following are significant projects which receive funding in excess of 500,000 euros.

BIOPASS: Image-, Ontology- and Process-Based Assistance for Minimally Invasive Endoscopic Surgery
Sub-project: Ontology-Based Information Integration and Automatic User Adaptation

Project director: Professor Thomas Neumuth (Faculty of Medicine, University Hospital; Innovation Center for Computer-Assisted Surgery (ICCAS))

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ENEFF – Gemeinsam auf dem Weg in die energieeffiziente urbane Moderne

Project director: Professor Thomas Bruckner (Faculty of Economics and Management Science, Institute for Infrastructure and Resource Management)

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InnoProfile-Transfer Junior Research Group Endowed Chair: Development of a Logistics Service Engineering and Management Approach for Value-Added Logistics (LSEM)

Project director: Dr Ludwig André (Faculty of Economics and Management Science, Information Systems Institute)

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PREsTiGE – Service Engineering für Collaborative BPaaS

Project director: Professor Bogdan Franczyk (Faculty of Economics and Management Science, Information Systems Institute)

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WindNODE – The Showcase for Intelligent Energy from Northeastern Germany. Analysis, Design and Simulation of Market-Based Instruments for the Integration of Network-Appropriate Flexibilities into Intelligent Energy Supply Systems with a High Share of Renewable Energies.

Project director: Professor Thomas Bruckner (Faculty of Economics and Management Science, Institute for Infrastructure and Resource Management)

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The Volkswagen Foundation is supporting Dr Carsten Meyer, a Leipzig University researcher based at iDiv, with one of its ‘Freigeist’ Fellowships.

‘Freigeist’ Fellowship: Modelling the Socioeconomic Forces behind 21st-Century Biodiversity Loss: A Macroscopic Approach to Turn Complexity into Opportunities for Action

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The International Max Planck Research School “The Leipzig School of Human Origins” (IMPRS LSHO) is a unique postgraduate programme that combines different disciplines to study the evolutionary history and origins of humans and other primates. The Leipzig School of Human Origins is a collaboration between Leipzig University and the Max Planck Institute for Evolutionary Anthropology.

Professor Thomas Bruckner
Institute for Infrastructure and Resource Management

Grimmaische Straße 12
04109 Leipzig

Phone: +49 341 97-33516
Fax: +49 341 97-33538

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Professor Roger Gläser
Institute of Chemical Technology

Linnéstraße 3
04103 Leipzig

Phone: +49 341 97-36300
Fax: +49 341 97-36349

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Professor Christian Wirth
Institute of Biology

Johannisallee 21 — 23
04103 Leipzig

Phone: +49 341 97-38591
Fax: +49 341 97-38549

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Molecular and Cellular Communication

Grafik zum Forschungsprofilbereich „ Molekulare und zelluläre Kommunikation in Therapie und Diagnostik“
Image: Daniel Janetzki, Visionauten

The research profile area of Molecular and Cellular Communication in Therapy and Diagnostics is devoted to investigating complex cell processes.

Communication between molecules, and interactions between cells and between molecules and cells, are essential foundations for the biochemical exchange of information. The research profile area aims to identify, characterise and understand these interactions. The researchers approach this from different angles: why does a cell change? How does it react to certain external influences? The research considers both human and animal cells. For example, the scientists are investigating clinical pictures of cancer and obesity as well as wound healing. Their research results should contribute to the development of new drugs and therapies.

CRC 1052: Obesity Mechanisms
The Obesity Mechanisms Collaborative Research Centre has been examining three main research foci since 2013: overeating, fat deposition and inflammation, and altered adipokine secretion. In cooperation with three partner institutions – the Max Planck Institute for Human Cognitive and Brain Sciences, the Helmholtz Centre for Environmental Research (UFZ) and Ben-Gurion University of the Negev (Israel) – the researchers aim to enhance our understanding of obesity as a multifactorial and socially relevant disease.

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TRR 67: Functional Biomaterials for Controlling Healing Processes in Bone and Skin – from Material Science to Clinical Application
In light of demographic developments in Germany and other industrialised nations, a drastic rise in the number of patients with bone defects and chronic wounds requires the development of novel functional biomaterials to improve bone and skin regeneration. To this end, Transregio 67 Functional Biomaterials is pursuing the goal of developing and testing such materials on the basis of artificial extracellular matrices. A joint effort with the TU Dresden, the initiative includes projects that deal predominantly with material science and chemistry (project area A), but also projects that focus on cell biology and clinical practice (project area B). The “T – Transfer” project area aims to promote development towards clinical translation. The Integrated Research Training Group “Matrix Engineering” forms part of the Transregio. With a structured postgraduate qualification programme, it offers the doctoral candidates advanced training modules to prepare them for their future work in research, and also acts as a bridge between the content and methodology of the individual sub-projects.

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Research work at the Research Training Group “Matrix Engineering”. Photo: Anett Albrecht
Research work at the Research Training Group “Matrix Engineering”. Photo: Anett Albrecht

 

IRTG 2324: Tree Diversity Interactions (TreeDi)

The International Research Training Group “TreeDi – Tree Diversity Interactions: The Role of Tree-Tree Interactions in Local Neighbourhoods in Chinese Subtropical Forests” led by the German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig together with the University of Chinese Academy of Sciences (UCAS) in China is investigating how tree-tree interactions in local neighbourhoods translate into the observed positive tree species richness effects on key ecosystem functions at the community level. The international qualification programme provides for intensive Chinese-German cultural exchange during a six-month research stay in the partner country. There is also a joint doctoral candidate advisory committee with Chinese and German project leaders and close cooperation with leading figures of biodiversity research.

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FOR 2149: Elucidation of Adhesion-GPCR Signalling
Adhesion-type G protein-coupled receptors form a large class of seven-transmembrane-spanning (7TM) receptors. In the past, these receptors have been shown to be essential components of countless physiological functions, and a veritable treasure trove for modern pharmacological intervention. Unlike other 7TM receptors, we know comparatively little about adhesion GPCR as a receptor class. The work conducted by the “Elucidation of Adhesion-GPCR Signalling” Research Unit focuses on unresolved fundamental questions about the biology of adhesion GPCR, with special attention paid to the physiological and pharmacological properties of their signalling behaviour.

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Jens Meiler was awarded a Humboldt Professorship in 2019. A pharmaceutical chemist and bioinformatics researcher, he conducts research where biology, physics, chemistry and computer science meet. At the new Institute for Innovation in Rational Drug Design, Meiler will carefully combine computer-aided processes with experimental methods in order to develop new pharmaceuticals. This will directly support the research profile area of Molecular and Cellular Communication in Therapy and Diagnostics – with whose scientists he already cooperated extensively before the award. Joint projects will further expand this cooperation in the future. 

SysMedOs – Integration of Oxidative Stress into Systems Medicine View for Obesity and Obesity-Related Complications

Project director: Dr Maria Fedorova (Faculty of Chemistry and Mineralogy, Institute of Bioanalytical Chemistry)

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Professor Annette Beck-Sickinger

Institute of Biochemistry

Brüderstraße 34
04103 Leipzig

Phone: +49 341 97-36901

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Professor Torsten Schöneberg

Institute of Biochemistry

Johannisallee 30
04103 Leipzig

Phone: +49 341 97-22150

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Brain Dynamics

Grafik zum Forschungsprofilbereich „Mensch und Gehirn“
Image: Daniel Janetzki, Visionauten

This research profile area investigates the basics of nervous system function, including movement control, speech, attention, perception and memory, and their variability.

The researchers investigate specific aspects of human behaviour and the human brain, early childhood and evolutionary development as well as neurological and psychiatric diseases such as depression, dementia, stroke, and attention and behavioural disorders. How is the release of neurotransmitters controlled? How does the brain recover from a stroke? What do hibernation and Alzheimer’s disease have in common? The Brain Dynamics research profile area concentrates research into the brain, its diseases and new treatment options.

CRC 1052: Obesity Mechanisms
The Obesity Mechanisms Collaborative Research Centre has been examining three main research foci since 2013: overeating, fat deposition and inflammation, and altered adipokine secretion. In cooperation with three partner institutions – the Max Planck Institute for Human Cognitive and Brain Sciences, the Helmholtz Centre for Environmental Research (UFZ) and Ben-Gurion University of the Negev (Israel) – the researchers aim to enhance our understanding of obesity as a multifactorial and socially relevant disease.

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CRC 1270: Electrically Active Implants – ELAINE
As the European population ages rapidly, the social and socio-economic relevance of regenerative therapies is steadily increasing. The research project ELAINE, which is led by the University of Rostock, concentrates on novel, electrically active implants for use in the regeneration of bone and cartilage.
Professor Angelika Richter from Leipzig University’s Institute of Pharmacology, Pharmacy and Toxicology is co-head of a sub-project focusing on deep brain simulation in models of dystonia.

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PP 1757: Functional Specialisations of Neuroglia as Critical Determinants of Brain Activity
The aim of Priority Programme 1757, which is coordinated by Professor Thomas Magin at the Institute of Biology, is to understand glial cell specialisation and its role in the mammalian brain.

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International Max Planck Research School on “Neuroscience of Communication: Function, Structure, and Plasticity” (IMPRS NeuroCom)

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Professor Jens Eilers

Carl Ludwig Institute for Physiology
Faculty of Medicine
Leipzig University

Liebigstraße 27
04103 Leipzig

Phone: +49 341 97-15520
Fax: +49 341 97-15529

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Professor Marc Schönwiesner

Institute of Biology

Talstraße 33 
04103 Leipzig

Phone: +49 341 97-36723
Fax: +49 341 97-36848 

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