Start date: 1st October, 2023
PhD position (3 years; TV-L 67%)
More than 35 % of commercially available drugs target G protein-coupled receptors (GPCRs) and are frequently used to treat a large spectrum of diseases including allergies, cardiovascular conditions or Morbus Parkinson. Adhesion-type GPCR constitute the second largest GPCR family and are found in every organ system. Consequently, malfunction of Adhesion-type GPCR causes numerous health issues, which can be neurological, neuropsychiatric, immunological or cardiovascular in nature. Despite the obvious pharmaceutical potential, no compounds are commercially available yet to interfere with adhesion GPCR malfunction i.e. to treat any of the associated conditions.
Recently, we developed a molecular sensor system (Scholz et al., 2023) that considers adhesion GPCR specifics and provides a novel tool to enter this mostly unchartered pharmaceutical territory for adhesion GPCR. In this context, we are currently assembling a team of six funded, by the German Federal Ministry of Education and Research and are looking to hire a PhD candidate that:
- holds a research diploma or master in biology, biochemistry or related subjects
- is experienced in basic molecular biology, cell biology, biochemistry and bioinformatics
- is interested in learning and employing a combination of in vitro methodologies
- is able to establish experimental strategies to answer biological questions
- is a critical thinker and 100% reliable
- is team-minded and strives to promote the team effort
We offer modern technical facilities, an international and collegial ambience, and a team striving to push the envelope in Adhesion GPCR research.
Interested?
Our most important publications:
Scholz N et al., Nature, 2023. doi: 10.1038/s41586-023-05802-5.
Bormann A et al., Biorxiv, 2023. doi: 10.1101/2023.01.11.521585.
Beliu G et al., Mol Cell, 2021. doi: 10.1016/j.molcel.2020.12.042.
Scholz N, Front Oncol, 2018. doi: 10.3389/fonc.2018.00059.
Langenhan T, Basic Clin Pharmacol Toxicol, 2019. doi: 10.1111/bcpt.13223.
Langenhan T et al., Nat Rev Neurosci, 2016. doi: doi.org/10.1038/nrn.2016.86.
Nieberler M et al., Handb Exp Pharmacol, 2016. doi: 10.1007/978-3-319-41523-9_5.
Scholz N et al., eLife, 2017. doi: 10.7554/eLife.28360.
Scholz N et al., Cell Rep, 2015. doi: 10.1016/j.ceIrep.2015.04.008.
@scholzlab
@langenhanlab
position announcement