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| Poster, Friday, 19:00 |
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| On the Interpretation of Optically
Induced Cell Deformations - Part I: Temperature Dependence
Tobias R. Kießling, Anatol
W. Fritsch, Roland Stange, Josef A. Käs
University of Leipzig, Faculty of
Physics and Earth Sciences, Institute of Experimental Physics I, Soft Matter
Physics Division, Linnéstraße 5, 04103 Leipzig, Germany |
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| Contact:
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Current improvements of the Optical Cell Stretcher technology have led
to significant higher throughput rates and consequently to better statistics
by providing easy access to optical and rheological properties of thousands
of living cells. This increased throughput rate opens up the possibility
to perform new kinds of optical stretcher measurements like long time behavior
studies, force spectroscopic measurements as well as detailed studies on
the influence of temperature. Challenging, however, are the processing,
analysis and interpretation of thereby recorded gigabytes of data, demanding
for a standardized evaluation workflow including sophisticated image analysis
algorithms. Thereby, network analysis approaches may help to reveal patterns
and relationships in recorded data sets and to identify useful biomechanical
metrics for cell type classification. |
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