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| Poster, Friday, 19:00 |
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| Impact of jamming on collective
cell dynamics
Kenechukwu David Nnetu, Melanie
Knorr, Dan Strehle, Steve Pawlizak, Thomas Fuhs, Mareike Zink, Josef A.
Käs
University of Leipzig, Faculty of
Physics and Earth Sciences, Institute of Experimental Physics I, Soft Matter
Physics Division, Linnéstraße 5, 04103 Leipzig, Germany |
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Multi-cellular migration plays a pivotal role in physiological processes
such as embryogenesis, cancer metastasis and tissue repair. During migration,
single cells undergo cycles of extension, adhesion and retraction which
results in morphological changes of the cells. In a confluent monolayer,
there are inter-cellular interactions and crowding, however, the impact
of these interactions on the dynamics and mechanics at the multi-cellular
and single cell level is not well understood. We study the dynamics
of a confluent epithelial monolayer by simultaneously measuring cell motion
at the single cell and multi-cellular level for various cell densities.
On short times scales, cell motion was random and decreased with increasing
cell density. At long time scales as the system approached kinetic
arrest, the dynamics was heterogeneous and ballistic. Interestingly, the
correlation length increased linearly with time and was well fitted by
compressed exponential function while the elastic modulus at the single
cell level scales as a weak power law with density. These observations
are similar to that of deformable colloidal systems whose fragility is
regulated by elastic property of individual particles as the system approaches
the glass transition. |
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