Nicole Scholz
Adhesion GPCR-mediated signaling across cells
Brain Dynamics Graduate School is happy to announce a new talk within our Seminar Series:
- Dr Nicole Scholz
Rudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, University Leipzig
"Adhesion GPCR-mediated signaling across cells"
1st March 2024, 12:00
Paul Flechsig Institute - Center of Neuropathology and Brain Research, Room 3093, Liebigstraße 19 (Haus C), 04103 Leipzig
Abstract:
Adhesion GPCR (aGPCR) are expressed in every organ system of the human body. They represent a large and rather peculiar group of biosensors that adopt and combine properties otherwise known from other cell surface molecules such as integrins, notch and protease-activated receptors.
Self-cleavage of aGPCR, which occurs in an evolutionarily conserved GPCR autoproteolysis-inducing (GAIN) domain, introduces a predetermined breaking point that was hypothesized to be relevant for potent aGPCR activation. Here, I will introduce a novel transgenic sensor system designed to track the physical separation of aGPCR fragments and will present new insight to latrophilin-type aGPCR Cirl/ADGRL receptor function in neural processes in vivo in Drosophila melanogaster.