Profile
Abstract
The research of Mareike Zink and her group is focused on the understanding the physics of cells and tissues for biomedical applications: How do topological cues influence cell adhesion and why is the interaction of cells with surfaces important for cell and tissue organization? Answers to these questions are the aim of our research within the Biotechnology and Biomedical Group.
By employing various microscopy techniques in combination with different force spectroscopy methods, as well as self-developed setups, the research group aim to get more insight into cell-surface interaction forces to correlate physical properties with biological aspects such as tissue structure and function. Moreover, the group use tissues from slaughter houses to study the mechanical properties of complex neuronal tissues such as the retina for a better understanding of eye diseases. By showing how nanostructured surfaces promote tissue adhesion and long-term survival for organotypic culture of adult tissue, the study also paves new ways in replacing animal experiments by ex vivo culture models. Additionally, Mareike Zink investigate tissue mechanics and their variations during development from an embryo to an adult to understand how structural changes (e.g. within the extracellular matrix) influence organ function or promote tumor growth.
- MUDIplex: Entwicklung einer Multiwell-Ultra High Dense-Mikroelektroden- und Oszillatorenarray-Multiplexer-Plattform für räumlich-zeitlich hochaufgelöstes Monitoring zellulärer Biomechanik im Live-ModusRobitzki, AndreaDuration: 02/2018 - 12/2020Funded by: SMWK Staatsministerium für Wissenschaft, Kultur und TourismusInvolved organisational units of Leipzig University: Biochemische Zelltechnologie; Peter-Debye-Institut für Physik der weichen Materie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)
- Orthotopic tumor transplantation experiments to verify the theory of ontogenetic cancer fieldsAktas, BahriyeDuration: 01/2017 - ongoingFunded by: Haushaltsmittel (TG51, Overhead); Stiftungen InlandInvolved organisational units of Leipzig University: Klinik und Poliklinik für Frauenheilkunde
- Plasmaunterstützte Funktionalisierung magnetischer Kern-Schale-Nanopartikel mit Biomolekülen für die medizinische Diagnostik (BIOCOAT)Zink, MareikeDuration: 02/2016 - 12/2018Funded by: Sächsische WirtschaftInvolved organisational units of Leipzig University: Physik weicher Materie/Zellbiophysik; Wechselwirkung von Oberflächen mit biologischen Zellen und Geweben; Biotechnologisch-Biomedizinisches Zentrum (BBZ)
- Organotypische Langzeitkultivierung von adultem Augengewebe zur Erforschung von Krankheiten und Wirkstofen in vitro - EYECULTUREZink, MareikeDuration: 08/2015 - 07/2022Funded by: BMBF Bundesministerium für Bildung und ForschungInvolved organisational units of Leipzig University: Physik weicher Materie/Zellbiophysik; Wechselwirkung von Oberflächen mit biologischen Zellen und Geweben; Biotechnologisch-Biomedizinisches Zentrum (BBZ); Sächsischer Inkubator für klinische Translation (SIKT)
- Dynamic-mechanical cell manipulation and characterization using magnetostrainZink, MareikeDuration: 07/2013 - 09/2021Funded by: DFG Deutsche ForschungsgemeinschaftInvolved organisational units of Leipzig University: Physik weicher Materie/Zellbiophysik; Wechselwirkung von Oberflächen mit biologischen Zellen und Geweben; Biotechnologisch-Biomedizinisches Zentrum (BBZ)
- Kupferer, A.; Mayr, S. G.; Zink, M.Influence of Topological Cues on Fibronectin Adsorption and Contact Guidance of Fibroblasts on Microgrooved TitaniumACS Applied Bio Materials. 2019. pp. 1066-1077
- Kallendrusch, S.; Merz, F.; Bechmann, I.; Mayr, S. G.; Zink, M.Long-Term Tissue Culture of Adult Brain and Spleen Slices on Nanostructured ScaffoldsAdvanced Healthcare Materials. 2017. 6 (9).
- Juncheed, K.; Kohlstrunk, B.; Friebe, S.; Dallacasagrande, V.; Maurer, P.; Reichenbach, A.; Mayr, S. G.; Zink, M.Employing Nanostructured Scaffolds to Investigate the Mechanical Properties of Adult Mammalian Retinae Under TensionInternational journal of molecular sciences. 2020. 21 (11).DOI: 10.3390/ijms21113889
- Abend, A.; Steele, C.; Schmidt, S.; Frank, R.; Jahnke, H.-G.; Zink, M.Neuronal and glial cell co-culture organization and impedance spectroscopy on nanocolumnar TiN films for lab-on-a-chip devicesBiomaterials Science. 2022.DOI: 10.1039/D2BM01066F
- Naumann, J.; Koppe, N.; Thome, U.; Laube, M.; Zink, M.Mechanical properties of the premature lung: from tissue deformation under load to mechanosensitivity of alveolar cellsFrontiers in Bioengineering and Biotechnology. 2022.
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Experimental Physics and mathematical methods EP2
Electrodynamics (Higher Education)
Modul 12-PHY-L-EP2-A