Profile

Professional career

• 06/2009 - 10/2009
  Visiting Professor Vanderbilt University, Nashville, TN, USA
• since 08/1999
  Full Professor (C4) of Bioorganic Chemistry and Biochemistry, Faculty of Life Sciences at Leipzig University
• 01/1997 - 07/1999
  Assistant Professor, Pharmaceutical Biochemistry, ETH Zürich, Department of Applied Chemistry, Switzerland
• 01/1992 - 12/1992
  Research Fellow at Rigshospitalet, Copenhagen, Denmark (T. W. Schwartz)
• 07/1990 - 12/1991
  Postdoctoral Fellow, ETH Zürich, Laboratory of Biochemistry, Switzerland (E. Carafoli)
• 01/1988 - 10/1988
  Research Stay at Scripps Clinic & Research Foundation, La Jolla, USA (R. A. Houghten)

Education

• 11/1989 - 10/1995
  Habilitation and venia legendi in Biochemistry, University of Tübingen
• 11/1986 - 10/1989
  Dissertation in Organic Chemistry, University of Tübingen
• 10/1982 - 10/1990
  Studies and Final Degree in Biology, University of Tübingen
• 10/1980 - 10/1986
  Studies and Final Degree in Organic Chemistry, University of Tübingen

Panel Memberships

• since 07/2021
  Member of the DFG Senate
• since 01/2021
  Member of the Academy of Science, Göttingen
• since 01/2020
  Speaker of the CRC 1423: Structural Dynamics of GPCR Activation and Signaling (DFG)
• 01/2019 - 03/2021
  President of the German Society for Biochemistry and Molecular Biology (GBM)
• since 01/2017
  Member of the Board of the German Society for Biochemistry and Molecular Biology (GBM); Vice President 2017-2019 and 2021-2023
• since 01/2015
  Member of the Senate Board of Evaluation of the Leibnitz Foundation
• since 01/2013
  Member of the Board of the CRC 1052: Obesity Mechanisms (DFG)
• since 01/2012
  Member of the German National Academy of Science, Leopoldina
• 01/2012 - 12/2018
  Member of the German Council of Science and Humanities(Wissenschaftsrat)
• 01/2011 - 03/2021
  Member of the University Council (Universitätsrat) University of Stuttgart-Hohenheim, speaker 2018-2021
• since 01/2010
  Member of the University Council (Hochschulrat) Leipzig, since 2018 vice speaker
• 07/2009 - 12/2021
  Member of the Board of the CRC-TR67 and Chair of the Graduate Programm “Matrix Engineering”
• since 01/2009
  Member of the Saxonian Academy of Sciences
• since 01/2009
  Member of the Advisory Board of the Mercator Foundation
• since 01/2008
  Member of the „Kuratorium des Fonds der Chemischen Industrie“ (FCI)
• 01/2002 - 12/2012
  Speaker of the CRC 610 „Variation in Protein Conformation: Cell biological and Pathological Relevance“ (DFG)
• since 07/2000
  Member of the Faculty of Chemistry and Mineralogy, Leipzig University

Annette G. Beck-Sickinger major reseach fields are structure-activity-relationships of peptide hormones and G protein coupled receptors and protein modification to study function and interaction. A tight connection of chemical methods, bioorganic synthesis and molecular biology tools, including cloning, receptor mutagenesis, protein expression and cell biochemistry is applied. Whereas in the first field, her interests go towards medicinal chemistry, identification of novel targets and novel therapeutic concepts e. g. in the field of cancer and obesity, the second field is related to biomaterials, novel approaches to modify proteins and concepts for improved enzyme catalysis.

• SFB 1423/A04: Characterizing the molecular interaction between the Y receptor and arrestin

  Huster, Daniel

  Duration: 01/2020 - 12/2023

  Funded by: DFG Deutsche Forschungsgemeinschaft

  Involved organisational units of Leipzig University: Biochemie/Bioorganische Chemie; Institut für Medizinische Physik und Biophysik; SFB 1423: Strukturelle Dynamik der GPCR-Aktivierung und Signaltransduktion
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• SFB 1423/B01: Molecular mechanisms of allosteric modulators at Y-receptors

  Beck-Sickinger, Annette

  Duration: 01/2020 - 12/2023

  Funded by: DFG Deutsche Forschungsgemeinschaft

  Involved organisational units of Leipzig University: Biochemie/Bioorganische Chemie; SFB 1423: Strukturelle Dynamik der GPCR-Aktivierung und Signaltransduktion
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• SFB 1052/A03: Targeting of central peptide receptors via nasal ligand application to modulate food intake

  Beck-Sickinger, Annette

  Duration: 07/2021 - 12/2024

  Funded by: DFG Deutsche Forschungsgemeinschaft

  Involved organisational units of Leipzig University: Biochemie/Bioorganische Chemie; Medizinische Fakultät und Universitätsklinikum AöR; SFB 1052: Mechanismen der Adipositas
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• SFB 1052/C08: Development of modulators at the chemokine-like receptor to elucidate its role in obesity

  Beck-Sickinger, Annette

  Duration: 07/2021 - 12/2024

  Funded by: DFG Deutsche Forschungsgemeinschaft

  Involved organisational units of Leipzig University: Biochemie/Bioorganische Chemie; Medizinische Fakultät und Universitätsklinikum AöR; SFB 1052: Mechanismen der Adipositas
  show details
• SFB 1052/B04: Targeted delivery of drugs into adipocytes by peptide-mediated shuttling in a new obesity mouse model

  Beck-Sickinger, Annette

  Duration: 07/2021 - 12/2024

  Funded by: DFG Deutsche Forschungsgemeinschaft

  Involved organisational units of Leipzig University: Biochemie/Bioorganische Chemie; Medizinische Fakultät und Universitätsklinikum AöR; SFB 1052: Mechanismen der Adipositas
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more projects

• Spiller, S.; Wippold, T.; Bellmann-Sickert, K.; Franz, S.; Saalbach, A.; Anderegg, U.; Beck-Sickinger, A.

  Protease-Triggered Release of Stabilized CXCL12 from Coated Scaffolds in an Ex Vivo Wound Model

  Pharmaceutics. 2021. 13 (10).

  DOI: 10.3390/pharmaceutics13101597
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• Isbilir, A.; Serfling, R.; Möller, J.; Thomas, R.; De Faveri, C.; Zabel, U.; Scarselli, M.; Beck-Sickinger, A.; Bock, A.; Coin, I.; Lohse, M. J.; Annibale, P.

  Determination of G-protein–coupled receptor oligomerization by molecular brightness analyses in single cells

  Nature protocols. 2021. 16 (3). pp. 1419-1451

  DOI: 10.1038/s41596-020-00458-1
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• Tang, T.; Findeisen, C.; Chen, Q.; Zhao, W.; Kaiser, A.; Zhang, X.; Zhang, H.; Qu, H.; Yi, C.; Ma, L.; Han, S.; Zhao, Q.; Beck-Sickinger, A.; Wu, B.

  Structural basis for ligand recognition of the neuropeptide Y Y-2 receptor

  Nature Communications. 2021. 12 (1).

  DOI: 10.1038/s41467-021-21030-9
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• Schüß, C.; Oanh Vu; Schubert, M.; Du, Y.; Mishra, N. M.; Tough, I. R.; Stichel, J. D.; Weaver, C. D.; Emmitte, K. A.; Cox, H. M.; Meiler, J.; Beck-Sickinger, A.

  Highly Selective Y-4 Receptor Antagonist Binds in an Allosteric Binding Pocket

  Journal of medicinal chemistry. 2021. 64 (5). pp. 2801-2814

  DOI: 10.1021/acs.jmedchem.0c02000
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• Heyder, N.; Kleinau, G.; Speck, D. et al.

  Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide

  Cell research. 2021. 31 (11). pp. 1176-1189

  DOI: 10.1038/s41422-021-00569-8
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more publications

• Andere herausragende Auszeichnungen: Du Vigneaud Award

  Beck-Sickinger, Annette (Biochemie/Bioorganische Chemie)

  awarded in 2019 by American Peptide Society.
  show details
• Andere herausragende Auszeichnungen: Albrecht-Kossel-Preis

  Beck-Sickinger, Annette (Biochemie/Bioorganische Chemie)

  awarded in 2018 by Gesellschaft Deutscher Chemiker.
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• Andere herausragende Auszeichnungen: Sächsischer Verdienstorden

  Beck-Sickinger, Annette (Biochemie/Bioorganische Chemie)

  awarded in 2017 by Freistaat Sachsen.
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• Andere herausragende Auszeichnungen: Max Bergmann Gold Metal

  Beck-Sickinger, Annette (Biochemie/Bioorganische Chemie)

  awarded in 2009 by Max Bergmann Kreis.
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• Andere herausragende Auszeichnungen: Chemistry Europe Fellow Award

  Beck-Sickinger, Annette (Biochemie/Bioorganische Chemie)

  awarded in 2019.
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more awards

• Biochemie/Bioorganische Chemie; Institut für Biochemie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)

  Vanderbilt-Leipzig Collaboration: International Student and Research Exchange Programme

  Start Date of Collaboration: 01/01/2009

  External participating organisations: Vanderbilt University (Nashville, United States)

  Involved persons: Beck-Sickinger, Annette; Meiler, Jens; Albrecht, Anett
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• Biochemie/Bioorganische Chemie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)

  Projet émergent TRAIL INNOVATHER

  Start Date of Collaboration: 01/10/2017

  Ended on: 30/09/2020

  Involved persons: Beck-Sickinger, Annette; Morgat, Clement
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more cooperations

• Internationale Tagung

  4GPCRnet 2022

  Biochemie/Bioorganische Chemie; Medizinische Fakultät und Universitätsklinikum AöR

  Event Organiser: Beck-Sickinger, Annette; Bock, Andreas; Liebscher, Ines

  26/09/2022 - 29/09/2022
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• Internationale Tagung

  34. Europäisches und 8. internationales Peptidsymposium

  Biochemie/Bioorganische Chemie; Institut für Biochemie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)

  Event Organiser: Beck-Sickinger, Annette

  04/09/2016 - 09/09/2016
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• Internationale Tagung

  11. Internationales NPY-PYY-PP Symposium

  Biochemie/Bioorganische Chemie; Institut für Biochemie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)

  Event Organiser: Beck-Sickinger, Annette

  22/08/2015 - 26/08/2015
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more events

• Modul "Receptor Biochemistry and Signal Transduction"

• Modul "Protein Chemistry/ Enzymology"

• Modul "Bioorganic Chemistry"

• Modul "Fundamentals of Biochemistry"

• Journalclub: Discussion of current biochemical publications

• Modul "Scientific work"