Profile
Abstract
Annette G. Beck-Sickinger is Professor of Biochemistry and Bioorganic Chemistry at the Faculty of Life Sciences at Leipzig University. She member of the Saxon Academy of Science, the German National Academy Leopoldina, the Göttingen Academy of Science and DFG Senate. Since 2020 she is spokesperson of the CRC1423 "Structural dynamics of GPCR activation and signaling".
She has been awarded with many prices including the Leonidas Zervas Award (EPS), the gold medal of the Max-Bergmann-Kreis, and the Albrecht Kossel Price (2018; GDCh). In 2017, she was awarded with the Saxonian Order of Merit. In 2019 she was honored with the Du Vigneaud Award (American Peptide Society) and in 2023 with the Richard Willstätter Prize for Chemical Biology.
Main research of her group is in the range of biochemical and bioorganic reserach and includes ligand receptor interactions of neuropeptides, signal transduction, protein expression and modification by ligation strategies as well as carrier peptides.
Professional career
- 06/2009 - 10/2009
Visiting Professor Vanderbilt University, Nashville, TN, USA - since 08/1999
Full Professor (C4) of Bioorganic Chemistry and Biochemistry, Faculty of Life Sciences at Leipzig University - 01/1997 - 07/1999
Assistant Professor, Pharmaceutical Biochemistry, ETH Zürich, Department of Applied Chemistry, Switzerland - 01/1992 - 12/1992
Research Fellow at Rigshospitalet, Copenhagen, Denmark (T. W. Schwartz) - 07/1990 - 12/1991
Postdoctoral Fellow, ETH Zürich, Laboratory of Biochemistry, Switzerland (E. Carafoli) - 01/1988 - 10/1988
Research Stay at Scripps Clinic & Research Foundation, La Jolla, USA (R. A. Houghten)
Education
- 11/1989 - 10/1995
Habilitation and venia legendi in Biochemistry, University of Tübingen - 11/1986 - 10/1989
Dissertation in Organic Chemistry, University of Tübingen - 10/1982 - 10/1990
Studies and Final Degree in Biology, University of Tübingen - 10/1980 - 10/1986
Studies and Final Degree in Organic Chemistry, University of Tübingen
Panel Memberships
- since 07/2021
Member of the DFG Senate - since 01/2021
Member of the Academy of Science, Göttingen - since 01/2020
Speaker of the CRC 1423: Structural Dynamics of GPCR Activation and Signaling (DFG) - 01/2019 - 03/2021
President of the German Society for Biochemistry and Molecular Biology (GBM) - since 01/2017
Member of the Board of the German Society for Biochemistry and Molecular Biology (GBM); Vice President 2017-2019 and 2021-2023 - since 01/2015
Member of the Senate Board of Evaluation of the Leibnitz Foundation - since 01/2013
Member of the Board of the CRC 1052: Obesity Mechanisms (DFG) - since 01/2012
Member of the German National Academy of Science, Leopoldina - 01/2012 - 12/2018
Member of the German Council of Science and Humanities(Wissenschaftsrat) - 01/2011 - 03/2021
Member of the University Council (Universitätsrat) University of Stuttgart-Hohenheim, speaker 2018-2021 - since 01/2010
Member of the University Council (Hochschulrat) Leipzig, since 2018 vice speaker - 07/2009 - 12/2021
Member of the Board of the CRC-TR67 and Chair of the Graduate Programm “Matrix Engineering” - since 01/2009
Member of the Saxonian Academy of Sciences - since 01/2009
Member of the Advisory Board of the Mercator Foundation - since 01/2008
Member of the „Kuratorium des Fonds der Chemischen Industrie“ (FCI) - 01/2002 - 12/2012
Speaker of the CRC 610 „Variation in Protein Conformation: Cell biological and Pathological Relevance“ (DFG) - since 07/2000
Member of the Faculty of Chemistry and Mineralogy, Leipzig University
Annette G. Beck-Sickinger major reseach fields are structure-activity-relationships of peptide hormones and G protein coupled receptors and protein modification to study function and interaction. A tight connection of chemical methods, bioorganic synthesis and molecular biology tools, including cloning, receptor mutagenesis, protein expression and cell biochemistry is applied. Whereas in the first field, her interests go towards medicinal chemistry, identification of novel targets and novel therapeutic concepts e. g. in the field of cancer and obesity, the second field is related to biomaterials, novel approaches to modify proteins and concepts for improved enzyme catalysis.
- SFB 1423/A04: Characterizing the molecular interaction between the Y receptor and arrestinHuster, DanielDuration: 01/2020 - 12/2023Funded by: DFG Deutsche ForschungsgemeinschaftInvolved organisational units of Leipzig University: Biochemie/Bioorganische Chemie; Institut für Medizinische Physik und Biophysik; SFB 1423: Strukturelle Dynamik der GPCR-Aktivierung und Signaltransduktion
- SFB 1423/B01: Molecular mechanisms of allosteric modulators at Y-receptorsBeck-Sickinger, AnnetteDuration: 01/2020 - 12/2023Funded by: DFG Deutsche ForschungsgemeinschaftInvolved organisational units of Leipzig University: Biochemie/Bioorganische Chemie; SFB 1423: Strukturelle Dynamik der GPCR-Aktivierung und Signaltransduktion
- SFB 1052/A03: Targeting of central peptide receptors via nasal ligand application to modulate food intakeBeck-Sickinger, AnnetteDuration: 07/2021 - 12/2024Funded by: DFG Deutsche ForschungsgemeinschaftInvolved organisational units of Leipzig University: Biochemie/Bioorganische Chemie; Medizinische Fakultät und Universitätsklinikum AöR; SFB 1052: Mechanismen der Adipositas
- SFB 1052/C08: Development of modulators at the chemokine-like receptor to elucidate its role in obesityBeck-Sickinger, AnnetteDuration: 07/2021 - 12/2024Funded by: DFG Deutsche ForschungsgemeinschaftInvolved organisational units of Leipzig University: Biochemie/Bioorganische Chemie; Medizinische Fakultät und Universitätsklinikum AöR; SFB 1052: Mechanismen der Adipositas
- SFB 1052/B04: Targeted delivery of drugs into adipocytes by peptide-mediated shuttling in a new obesity mouse modelBeck-Sickinger, AnnetteDuration: 07/2021 - 12/2024Funded by: DFG Deutsche ForschungsgemeinschaftInvolved organisational units of Leipzig University: Biochemie/Bioorganische Chemie; Medizinische Fakultät und Universitätsklinikum AöR; SFB 1052: Mechanismen der Adipositas
- Spiller, S.; Wippold, T.; Bellmann-Sickert, K.; Franz, S.; Saalbach, A.; Anderegg, U.; Beck-Sickinger, A.Protease-Triggered Release of Stabilized CXCL12 from Coated Scaffolds in an Ex Vivo Wound ModelPharmaceutics. 2021. 13 (10).
- Isbilir, A.; Serfling, R.; Möller, J.; Thomas, R.; De Faveri, C.; Zabel, U.; Scarselli, M.; Beck-Sickinger, A.; Bock, A.; Coin, I.; Lohse, M. J.; Annibale, P.Determination of G-protein–coupled receptor oligomerization by molecular brightness analyses in single cellsNature protocols. 2021. 16 (3). pp. 1419-1451
- Tang, T.; Findeisen, C.; Chen, Q.; Zhao, W.; Kaiser, A.; Zhang, X.; Zhang, H.; Qu, H.; Yi, C.; Ma, L.; Han, S.; Zhao, Q.; Beck-Sickinger, A.; Wu, B.Structural basis for ligand recognition of the neuropeptide Y Y-2 receptorNature Communications. 2021. 12 (1).
- Schüß, C.; Oanh Vu; Schubert, M.; Du, Y.; Mishra, N. M.; Tough, I. R.; Stichel, J. D.; Weaver, C. D.; Emmitte, K. A.; Cox, H. M.; Meiler, J.; Beck-Sickinger, A.Highly Selective Y-4 Receptor Antagonist Binds in an Allosteric Binding PocketJournal of medicinal chemistry. 2021. 64 (5). pp. 2801-2814
- Heyder, N.; Kleinau, G.; Speck, D. et al.Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotideCell research. 2021. 31 (11). pp. 1176-1189
- Andere herausragende Auszeichnungen: Du Vigneaud Awardshow detailsBeck-Sickinger, Annette (Biochemie/Bioorganische Chemie)awarded in 2019 by American Peptide Society.
- Andere herausragende Auszeichnungen: Albrecht-Kossel-Preisshow detailsBeck-Sickinger, Annette (Biochemie/Bioorganische Chemie)awarded in 2018 by Gesellschaft Deutscher Chemiker.
- Andere herausragende Auszeichnungen: Sächsischer Verdienstordenshow detailsBeck-Sickinger, Annette (Biochemie/Bioorganische Chemie)awarded in 2017 by Freistaat Sachsen.
- Andere herausragende Auszeichnungen: Max Bergmann Gold Metalshow detailsBeck-Sickinger, Annette (Biochemie/Bioorganische Chemie)awarded in 2009 by Max Bergmann Kreis.
- Andere herausragende Auszeichnungen: Chemistry Europe Fellow Awardshow detailsBeck-Sickinger, Annette (Biochemie/Bioorganische Chemie)awarded in 2019.
- Biochemie/Bioorganische Chemie; Institut für Biochemie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)Vanderbilt-Leipzig Collaboration: International Student and Research Exchange ProgrammeStart Date of Collaboration: 01/01/2009External participating organisations: Vanderbilt University (Nashville, United States)Involved persons: Beck-Sickinger, Annette; Meiler, Jens; Albrecht, Anett
- Biochemie/Bioorganische Chemie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)Projet émergent TRAIL INNOVATHERStart Date of Collaboration: 01/10/2017Ended on: 30/09/2020Involved persons: Beck-Sickinger, Annette; Morgat, Clement
- Internationale Tagung4GPCRnet 2022Biochemie/Bioorganische Chemie; Medizinische Fakultät und Universitätsklinikum AöREvent Organiser: Beck-Sickinger, Annette; Bock, Andreas; Liebscher, Ines26/09/2022 - 29/09/2022
- Internationale Tagung34. Europäisches und 8. internationales PeptidsymposiumBiochemie/Bioorganische Chemie; Institut für Biochemie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)Event Organiser: Beck-Sickinger, Annette04/09/2016 - 09/09/2016
- Internationale Tagung11. Internationales NPY-PYY-PP SymposiumBiochemie/Bioorganische Chemie; Institut für Biochemie; Biotechnologisch-Biomedizinisches Zentrum (BBZ)Event Organiser: Beck-Sickinger, Annette22/08/2015 - 26/08/2015
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Modul "Receptor Biochemistry and Signal Transduction"
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Modul "Protein Chemistry/ Enzymology"
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Modul "Bioorganic Chemistry"
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Modul "Fundamentals of Biochemistry"
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Journalclub: Discussion of current biochemical publications
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Modul "Scientific work"