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Prof. Dr. Tobias Langenhan

Prof. Dr. Tobias Langenhan

Universitätsprofessor

Haus J
Johannisallee 30
04103 Leipzig

Phone: +49 341 97 - 22100
Fax: +49 341 97 - 22109

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Abstract

I focus on the role and signalling rationale of G protein-coupled receptors of the adhesion family (adhesion GPCRs). I am interested in the physiological context, in which adhesion GPCRs operate, which sensory stimuli they perceive, how they convert them into cellular responses, and how ailments can arise from their dysfunction. A second research topic of my lab is the investigation of synaptic proteins and how their molecular properties contribute to the process of transmitter release. I am utilising invertebrate model organisms such as the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster for in vivo studies capitalising on their accessibility to genetic manipulation, physiological, biophysical, imaging and behavioural readouts. Combined with biochemical and cell-based analyses I seek to determine the principles that underlie the molecular actions of adhesion GPCRs and synaptic actuators in health and diseases such as neuropsychiatric ailments and cancer.


Professional career

  • since 05/2023
    Scientific co-director, University Cancer Center Leipzig, University Hospital Leipzig
  • since 03/2022
    Adjunct professor, Institute of Biology, Faculty of Life Sciences, Leipzig University
  • since 10/2016
    Full professor for Biochemistry, Chair of General Biochemistry, Rudolf Schönheimer Institute for Biochemistry, Medical Faculty, Leipzig University
  • 05/2016 - 09/2016
    Heisenberg professor, Institute of Physiology & Comprehensive Heart Failure Center, Medical Faculty, University of Würzburg
  • 07/2009 - 04/2016
    Group leader, Institute of Physiology, Medical Faculty, University of Würzburg

Education

  • 10/2005 - 06/2009
    Doctoral studies in Neurosciences (D.Phil.), University of Oxford, UK
  • 09/2004 - 09/2005
    Studies in Neuroscience, University of Oxford, UK
  • 09/2000 - 01/2006
    Doctoral studies in Medicine (Dr. med.), University of Würzburg
  • 10/1997 - 06/2004
    Studies in Medicine, University of Würzburg

Panel Memberships

  • 01/2011 - 10/2024
    "Adhesion GPCR Consortium"Chair and board member
  • 01/2015 - 12/2022
    DFG Research Unit 2149 "Adhesion GPCR signalling"Spokesperson
  • since 11/2024
    "Adhesion GPCR Consortium"Board member

  • Scholz, N.; Dahse, A.-K.; Kemkemer, M. et al.
    Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation
    Nature. 2023. pp. 945–953.
    DOI: 10.1038/s41586-023-05802-5
    show details
  • Buhlan, M.; Ljaschenko, D.; Scholz, N.; Langenhan, T.
    Experimental modulation of physiological force application on leg joint neurons in intact Drosophila melanogaster
    Nature protocols. 2023. pp. 113–126.
    DOI: 10.1038/s41596-023-00907-7
    show details
  • Paul, M. M.; Dannhaeuser, S.; Morris, L. et al.
    The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release
    Brain. 2022. 145 (11). pp. 3787–3802.
    DOI: 10.1093/brain/awac011
    show details
  • Beliu, G.; Altrichter, S.; Guixa-Gonzalez, R.; Hemberger, M. I.; Brauer, I.; Dahse, A.-K.; Scholz, N.; Wieduwild, R.; Kuhlemann, A.; Batebi, H.; Seufert, F.; Perez-Hernandez, G.; Hildebrand, P. W. R.; Sauer, M.; Langenhan, T.
    Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain
    Molecular cell. 2021. 81 (5). pp. 905–921.e5.
    DOI: 10.1016/j.molcel.2020.12.042
    show details

more publications

Research fields

Biochemistry, Pharmacology, Neurobiology, Neuroscience, Neurophysiology, Tumour biology, Cancer research, oncology

Contact for media inquiries

Phone: +49 341 97 22 100
Fax: +49 341 97 22 109